A5041924343- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Metal and Thin Film Mechanics
- Semiconductor materials and devices
- Skin and Cellular Biology Research
- Welding Techniques and Residual Stresses
- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- Medicine, History, and Philosophy
- Cardiomyopathy and Myosin Studies
- Landfill Environmental Impact Studies
- Sexual Differentiation and Disorders
- Testicular diseases and treatments
- Cutaneous lymphoproliferative disorders research
- Non-Destructive Testing Techniques
- Robot Manipulation and Learning
- Asthma and respiratory diseases
- Dermatological and Skeletal Disorders
- Veterinary Medicine and Surgery
- Low-power high-performance VLSI design
- Cholesterol and Lipid Metabolism
- Ocular Oncology and Treatments
Futaba (Japan)
2021-2024
Shionogi (Japan)
2021-2024
Keio University
1995-2023
Tachikawa Hospital
2017
Japan Atomic Energy Agency
2008
Sony Computer Science Laboratories
1998-1999
Yamaguchi University
1999
BACKGROUND Squamous tumours of the ocular surface, including lacrimal pathway, range from benign lesions to invasive carcinomas. Some these are associated with human papillomavirus (HPV) infection, types HPV differing among papillomas and dysplastic or malignant lesions. METHODS The relation between squamous conjunctiva sac infection was investigated in 17 individuals such tumours. Nine were benign, four lesions, RESULTS Eight specimens showed positive immunohistochemical staining antibodies...
Significance Immune tolerance is crucial to prevent harmful immune reactions against self-antigens and well operated by central thymic peripheral tissue tolerance. However, had been investigated under influence from We successfully decoupled utilizing autoantigen-deficient thymus. Experiments revealed that self-antigen presentation in steady state initiated proliferation but subsequent disappearance of autoreactive CD4 + T cells draining lymph nodes. After screening representative...
Interleukin-27 (IL-27) is an immunoregulatory cytokine whose essential function to limit immune responses. We found that the gene encoding cholesterol 25-hydroxylase (Ch25h) was induced in CD4
Abstract The pathological mechanisms and immunological kinetics of drug‐induced hypersensitivity syndrome (DIHS), including the relevance interleukin (IL)‐6, remain unclear. We report a case drug adverse reaction that does not fulfill diagnostic criteria DIHS but mimics its characteristic features. Because patient was under anti‐IL‐6 therapy at onset, some symptoms typically seen in were absent, such as fever leukocyte count abnormalities. However, features clearly observed subsequent...
Pemphigus vulgaris is an autoimmune blistering disease caused by IgG targeting desmoglein 3 (Dsg3), adhesion molecule of keratinocytes. Anti-Dsg3 production prevented in healthy individuals, but it unclear how Dsg3-specific B cells are regulated. To clarify the immunological condition regulating cells, a pathogenic anti-Dsg3 Ig (AK23) knock-in mouse was generated. AK23 developed normally without undergoing deletion or acquiring anergic phenotype vivo. The showed Ca2+ influx upon IgM...
Duplicate testes lined in series were observed the right scrotum of a 6-week-old Sprague-Dawley rat single-dose toxicity study. Of two testicles, one was spherical and less than half size normal testis. The other oval-shaped, slightly smaller testis, possessed clear, tortuous blood vessels similar to those Each testis grossly separated but faced intertesticular adipose tissue sparsely joined by thin cord-like structures. Only epididymis covered or encompassed testes. caput attached whereas...
Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4+ T cells expressing a transgenic cell receptor specific for desmoglein 3 (Dsg3), which target antigen of bullous disease pemphigus vulgaris, to examine how peripheral immunological tolerance against pathogenic autoreactive changes age. Dsg3-specific were deleted within 14 days after adoptive transfer into young mice (8 weeks old), while they escaped deletion when transferred...
A 24 kd protein from Rhipicephalus sanguineus (Rs24p) which was common to larvae, nymphs, male and female whole body salivary gland extract of males detected specifically in the serum dogs after repeated infestation with adult R. sanguineus. The duration antibodies against Rs24p infested adults examined by Western blotting analysis. Anti-Rs24p antibody two 4 during period 40 days first infestation. In second infestation, all showed positive reaction Rs24p, but varied greatly among animals.
A 6-month-old female beagle dog, assigned to the low-dose group in a toxicity study, was evaluated for compound toxicity, and spontaneous hyperadrenocorticism suspected. The animal had an externally apparent distended abdomen on clinical examination upon arrival. Pre-dose pathology showed slightly higher erythroid parameters stress leukogram hematology; plasma biochemistry total protein, gamma-glutamyl transferase, cholesterol, triglyceride levels than reference data. On necropsy, prominent...
A method of simulating the profile thin metallic films produced by low-pressure CVD is reported. This can calculate profiles under surface-reaction-limited conditions and transport-limited conditions. Surface reactions transport source-gas molecules in a chamber are modelled for method. In order to simulate profile, surface were calculated using Monte Carlo model was derived analytically. The dependence growth rate on partial pressure source gas analytically combining determine...
A new structure is proposed for a logic compatible merged-type DRAM gain cell, and device process simulations are performed to verify the cell operation. This enables realization of memory without direct use capacitor, almost with conventional CMOS process. Therefore, it does not require materials nor processing equipment, can be realized in less than 5% increase steps comparison 50%-60% or more embedded DRAM's one-capacitor+one-transistor cell. It drastically improve "1" "0" states'...
ABSTRACT Although immunoglobulin class-switching is essential for humoral immunity, its role in B-cell immune tolerance remains unclear. Pemphigus vulgaris an autoimmune blistering disease caused by IgG targeting desmoglein 3, adhesion molecule of keratinocytes. In this study, we generated knock-in mice that express anti-Dsg3 AK23 autoantibodies. Knock-in B cells developed normally vivo and showed Ca 2+ influx upon IgM cross-linking vitro . The predominantly produced circulating but little...
Summary In welding by a robot with visual sensor, the high intensity arc glare has an adverse influence on detection and recognition of weld line which is tracked torch. Therefore, effects light conditions sensing are investigated. Furthermore, in order to reduce light, method using pulse current proposed. That is, controlled computer used, images taken CCD camera when low. Because image at low condition, reduced robust vision system can be constructed.