A5031659373- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Cell Adhesion Molecules Research
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Macrophage Migration Inhibitory Factor
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Eosinophilic Disorders and Syndromes
- Pharmacological Effects of Natural Compounds
- Nuclear Receptors and Signaling
- Multiple Sclerosis Research Studies
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Drug-Induced Adverse Reactions
Showa University
2015-2024
Showa University Hospital
2020
Showa University Northern Yokohama Hospital
2020
Memorial Hospital of South Bend
2020
Murata (United States)
2020
Weatherford College
2020
Arthritis and Rheumatism Associates
2020
Ono Pharmaceutical (Japan)
2020
Teijin (Japan)
2020
Nippon Kayaku (Japan)
2020
<h3>Objective:</h3> We aimed to analyze the clinical and histopathologic features of cancer-associated myositis (CAM) in relation anti–transcriptional intermediary factor 1 γ antibody (anti-TIF1-γ-Ab), a marker cancer association. <h3>Methods:</h3> retrospectively studied 349 patients with idiopathic inflammatory myopathies (IIMs), including 284 pretreatment biopsy samples available. For classification IIMs, European Neuromuscular Center criteria were applied. Patients CAM (anti-TIF1-γ-Ab[+]...
<h3>Objective:</h3> To show cancer association is a risk factor other than statin exposure for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase autoantibody-positive (anti-HMGCR Ab+) myopathy. <h3>Methods:</h3> We analyzed the clinical features and courses of 33 patients (23 female 10 male) with anti-HMGCR Ab+ myopathy among 621 consecutive idiopathic inflammatory myopathies. <h3>Results:</h3> Among patients, 7 (21%) were statin-exposed 26 statin-naive. In relation cancer, there 12...
Chemokines play an essential role in the progression of rheumatoid arthritis (RA). In present study we examined expression and regulatory mechanisms IFN-γ inducible protein (IP)-10 RA synovitis. synovial fluid contained greater amounts IP-10 than did from patients with osteoarthritis. Immunolocalization analysis indicated that was associated mainly infiltrating macrophage-like cells, fibroblast-like cells synovium. The interaction activated leukocytes synoviocytes resulted marked increases...
Objective. To examine the relation between serum chemokine levels and patient responsiveness to infliximab, influence of infliximab administration on levels. Methods. Serum chemokines CX3CL1, CXCL8, CCL3, CXCL10 were quantified prior (at baseline) after 30 weeks treatment with in 20 patients using enzyme-linked immunosorbent assays. Disease status was assessed Activity Score (DAS28). The response classified according European League Against Rheumatism (EULAR) criteria. Results. By weeks,...
We evaluated the occurrence of cytomegalovirus (CMV) infection and background characteristics in twenty-three hospitalized patients with inflammatory connective tissue diseases including systemic lupus erythematosus, polymyositis/dermatomyositis, rheumatoid vasculitis, microscopic polyangitis, Takayasu's arteritis. Cytomegalovirus antigenemia was demonstrated 10 23 evaluable patients. Five ten CMV developed symptomatic disease (all cases fever, two liver involvement, interstitial pneumonia,...
Abstract We present six cases of antimelanoma differentiation‐associated gene 5 antibody (anti‐MDA5‐Ab)‐positive clinically amyopathic dermatomyositis (CADM) with rapidly progressive interstitial lung disease (RP‐ILD), which is known to have a poor prognosis. The outcomes these are described after treatment therapeutic plasma exchange (TPE). Clinical and data for patients CADM RP‐ILD were collected retrospectively from medical records. All received early intensive care including high‐dose...
We evaluated the occurrence of cytomegalovirus (CMV) infection and background characteristics in twenty-three hospitalized patients with inflammatory connective tissue diseases including systemic lupus erythematosus, polymyositis/dermatomyositis, rheumatoid vasculitis, microscopic polyangitis, Takayasu's arteritis. Cytomegalovirus antigenemia was demonstrated 10 23 evaluable patients. Five ten CMV developed symptomatic disease (all cases fever, two liver involvement, interstitial pneumonia,...
A disintegrin and metalloproteases (ADAMs) are a family of proteins that have been reported to be involved in several inflammatory conditions. We examined the secretion ADAM-10 biological fluids from patients with rheumatoid arthritis (RA) role it plays monocyte migration. levels were measured using enzyme-linked immunosorbent assays immunofluorescence. To examine RA synovial (SFs), we studied THP-1 (human acute leukemia cell line) chemotaxis. determine whether proliferation synovium,...
The characteristics of Pneumocystis carinii pneumonia (PCP) in patients with connective tissue diseases (CTDs) were examined retrospectively. Nine enrolled this study. Their mean age was 57.1 years. All the received a high-dose steroid or immunosuppressant. onset (mean 6.6 days) fever, cough, breathlessness, and geographical ground-glass opacities revealed by chest computed tomography acute. serum beta-D: -glucan level increased simultaneous increase Krebs von den Lungen (KL)-6 surfactant...
Objective To examine the dose-specific effects of interleukin-12 (IL-12) on evolution murine type II collagen–induced arthritis (CIA). Methods From day 24 through 33 following primary immunization, mice received daily intraperitoneal injections recombinant IL-12. Measurements anticollagen IgG, cytokines, and corticosterone were performed using enzyme-linked immunosorbent assay radioimmunoassay. Results CIA injected with a low dose IL-12 (5 ng/day) exhibited accelerated onset increased...
The aim was to determine the efficacy of low-dose intermittent pulse administration mizoribine (MZR), a purine synthesis inhibitor, in combination with methotrexate (MTX) control symptoms rheumatoid arthritis (RA) patients an insufficient clinical response MTX alone. Twenty-seven active RA, despite treatment MTX, were enrolled and given MZR continued for 24 weeks. primary endpoint assessment improvements using European League against Rheumatism (EULAR) criteria. Administering RA produced...
Macrophage migration inhibitory factor (MIF) is recognized to be an important mediator in several inflammatory disorders, including rheumatoid arthritis (RA) and vasculitis. To evaluate the role of MIF vasculitis (RV), we determined serum levels by enzyme-linked immunosorbent assay RA patients with without assessed their relationship disease activity. Serum was obtained from 95 during active states [49 vasculitis, 35 extra-articular manifestations histologically proven 11 vasculitis] 22...
Objective: This research examines the diagnostic performance of Japanese version GAD-7 (J-GAD-7) based on analysis two independent studies. The first assesses accuracy J-GAD-7 in identifying generalized anxiety disorder (GAD) primary care (Study 1). Next, a meta-analysis studies five language versions (English, Spanish, Dutch, Turkish, and German) is conducted 2), results which are compared with those J-GAD-7. Methods：In Study 1, subjects (n=161; male=55, female=106) returned self-rating...
In Sjögren's syndrome (SS), oral dryness (xerostomia) is frequently the most bothersome symptom. An H2 histamine receptor antagonist often administered to SS patients treat associated superficial gastritis. The aim of present study was assess ability nizatidine, an antagonist, also relieve xerostomia in with primary SS. Twenty-seven were randomly assigned receive nizatidine (n=14, 300 mg a day) or another blocker, famotidine (n=13, 40 day; control), followed for eight weeks, and asked both...
A 74-year-old woman was experiencing rheumatoid arthritis complicated with interstitial pneumonitis (IP), and tacrolimus treatment started. She presented dyspnea. Chest X-ray computed tomography (CT) showed ground-glass opacity IP. Although stopped, she died of respiratory failure. At autopsy, both the upper lower lung fields usual IP organizing stage diffuse alveolar damage. The former is common, but latter uncommon, suggesting may cause severe
Objective Although previous studies have reported the prognostic factors for functional remission, no reports cited predictive factors. Our aim was to study which is a treatment goal in rheumatoid arthritis (RA), after receiving biological disease-modifying antirheumatic drugs (bDMARDs) six months.
Macrophage migration inhibitory factor (MIF) is recognized to be an important mediator in several inflammatory disorders, including rheumatoid arthritis (RA) and vasculitis. To evaluate the role of MIF vasculitis (RV), we determined serum levels by enzyme-linked immunosorbent assay RA patients with without assessed their relationship disease activity. Serum was obtained from 95 during active states [49 vasculitis, 35 extra-articular manifestations histologically proven 11 vasculitis] 22...