A5059893288- Neurological and metabolic disorders
- Pharmacological Effects and Toxicity Studies
- IgG4-Related and Inflammatory Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cerebrovascular and genetic disorders
- Myasthenia Gravis and Thymoma
- Cancer Treatment and Pharmacology
- Cerebral Venous Sinus Thrombosis
- Neurological disorders and treatments
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Cancer Immunotherapy and Biomarkers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infective Endocarditis Diagnosis and Management
- Ion channel regulation and function
- Autoimmune Neurological Disorders and Treatments
- Oropharyngeal Anatomy and Pathologies
- Alcoholism and Thiamine Deficiency
- Sphingolipid Metabolism and Signaling
- Brain Metastases and Treatment
- Neurogenetic and Muscular Disorders Research
- Streptococcal Infections and Treatments
- Head and Neck Surgical Oncology
- Otitis Media and Relapsing Polychondritis
- Intracranial Aneurysms: Treatment and Complications
Akita University
2012-2024
Akita University Hospital
2020
Suzuki (Japan)
2012
Amyotrophic lateral sclerosis (ALS) exhibits selective muscle weakness. The weak shoulder and arm sparing signs, assessed by a single experienced neurologist, have been reported to be superior previous signs in sensitivity specificity. However, it is unknown whether the same results are observed when multiple neurologists.
This study aimed to clarify the frequency and clinical features of monogenic cerebral small vessel disease (mgCSVD) among patients with adult-onset severe CSVD in Japan.This included an age onset ≤55 years (group 1) or >55 a positive family history 2). After conducting conventional genetic tests for NOTCH3 HTRA1, whole-exome sequencing was performed on undiagnosed patients. Patients were divided into two groups according results tests: undetermined. The imaging compared between groups.Group...
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Guillain-Barré syndrome (GBS) typically occurs after gastroenteritis and respiratory tract infection, but surgery has also been considered one of the triggers. Posterior reversible encephalopathy (PRES) is a rare complication GBS. A normotensive female in her 70s presented ascending paralysis frontal-parieto-occipital subcortical lesions with intermittent hypertension spinal surgery. Nerve conduction studies revealed demyelinating polyneuropathy. The patient's brain disappeared amelioration...
Metformin causes metabolic encephalopathy in some patients with end-stage chronic kidney disease, resulting impaired consciousness and parkinsonism. This has a very characteristic magnetic resonance imaging feature lentiform nuclei known as the "lentiform fork sign". However, mechanism is unknown. Here, we report case of metformin-induced novel observation lactate accumulation on spectroscopy without systemic lactic acidosis. Since metformin an inhibitor mitochondrial complex-I, this focal...
While tyrosine kinase inhibitors (TKI)-associated cerebral vascular stenosis (CVS) exhibit distinct mechanisms compared to conventional stroke in basic research, the clinical strategy remains nearly same other than TKI-switching. We present case of a 22-year-old female with chronic myeloid leukemia without risk factors, who developed ponatinib-associated CVS. Three potential characteristics TKI-associated CVS were identified: heightened threshold for infarction, an atypical infarct area, and...
MS (multiple sclerosis) has specific criteria to avoid misdiagnosis. However, the Marburg variant of is so fulminant that initial axonal damage and other atypical observations have been allowed in past reports. We present a 74-year-old autopsy case with vanishing tumor after steroids radiation therapy, which was pathologically diagnosed as loss. The displayed radiological lymphoma-like observations: mass effects protruding lateral ventricle, fused extension from choroid plexus white matter C...
Lemierre syndrome is a life-threatening but treatable septic thrombosis of the internal jugular vein (IJV) derived from craniocervical bacterial infection. Metastatic embolization common. However, diagnostic delay and poor prognosis remain problem, largely due to diverse clinical presentations unclear symptomatology syndrome. In contrast, occipital neuralgia common disease typically treated with symptomatic therapy in emergency settings, as most cases are not life-threatening. The present...
We herein report a 48-year-old man with neurosyphilis manifesting as limbic encephalitis, initially suspected to be autoimmune encephalitis. The patient exhibited rapid behavioral changes, and magnetic resonance imaging showed high-intensity lesions in both medial temporal lobes. diagnosis was based on symptoms, cerebrospinal fluid abnormalities, positive serum tests for syphilis. Notably, the immunoglobulin G index markedly elevated (4.91). This case highlights diagnostic challenges...
Abstract A 62‐year‐old woman who was prescribed prednisolone and cyclosporine for uveitis developed right blepharoptosis, diplopia hypesthesia of superficial sensation the trigeminal nerve V1 domain. Preserved visual acuity led to a diagnosis superior orbital fissure syndrome. We could not find any abnormalities on computed tomography except maxillary sinusitis associated with calcification. No infectious agents were detected in blood or cerebrospinal fluid. concluded that aspergillus, which...
症例は66歳の男性．頭痛出現の6日後に内外眼筋麻痺を中心とした多発脳神経障害が急速に進行した．脳MRIでは両側海綿静脈洞が造影不良で血栓化を示唆し，左側では内頸動脈瘤が見られた．髄液では多核球優位に細胞が増多し，糖が減少した．抗凝固薬と抗菌薬を投与し，右海綿静脈洞血栓(CST)は溶解され髄膜炎は改善したが，内頸動脈瘤は増大し大脳皮質に感染性動脈瘤が出現した．抗菌薬継続で動脈瘤は縮小したが，左CSTは溶解されず左内外眼筋麻痺は残存した．CT上，蝶形骨洞上壁に骨の菲薄化と欠損が認められ，同部位を介し蝶形骨洞炎から細菌が海綿静脈洞に波及し血栓化した機序が推定された．細菌は髄膜と内頸動脈にも波及し，生じた内頸動脈瘤は大脳皮質感染性動脈瘤の塞栓源になったと考えられた．抗菌薬が発達した現在CSTは稀とされるが，蝶形骨洞の骨壁異常を持つ者では発症に留意する必要があると考えられた．
We experienced a case of generalized myasthenia gravis and myositis occurring as immune-related adverse events that was curable without steroid therapy, only through the discontinuation immune checkpoint inhibitor. Although patient did not receive cancer treatment afterwards, her remained stable. emphasize selecting therapy might enhance effect immunotherapy.
Ophelia syndrome is paraneoplastic limbic encephalitis (PLE) with Hodgkin lymphoma. Some patients have been reported as testing positive for anti-metabotropic glutamate receptor 5 (mGluR5) antibodies. However, we experienced a case of anti-mGluR5 antibody-negative syndrome. The type onset, neurological symptoms, and imaging well electroencephalographic findings were like previous reports except normal cell count in cerebrospinal fluid (CSF). Unfortunately, lymph node biopsy failed could not...
Although belching is mostly associated with gastrointestinal disorders, it occasionally accompanies movement disorders such as Parkinsonism or dystonia. A woman in her 80s presented distressing and chorea of the right arm leg from 3 years earlier. brain MRI showed a left caudate infarction atrophic change. Haloperidol significantly improved chorea. Caudate can cause It might be important to select appropriate drug by referring accompanying involuntary treat disorders.