A5089531189- Neurological disorders and treatments
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Pluripotent Stem Cells Research
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Neurogenesis and neuroplasticity mechanisms
- Vagus Nerve Stimulation Research
- Spinal Cord Injury Research
- CRISPR and Genetic Engineering
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Functional Brain Connectivity Studies
- Infrared Thermography in Medicine
- Multisensory perception and integration
- Child and Animal Learning Development
- Photoreceptor and optogenetics research
- Thermal Regulation in Medicine
Yamaguchi University
2024-2025
National Institute for Physiological Sciences
2007-2022
The Graduate University for Advanced Studies, SOKENDAI
2007-2020
Kyushu Institute of Technology
2008
The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we show the efficacy major histocompatibility complex (MHC)-matched allogeneic neural grafting in brain, which less immune-responsive tissue, using iPSCs derived from an MHC homozygous cynomolgus macaque. Positron emission tomography imaging reveals neuroinflammation...
This study aimed to assess the effects of focal brain cooling (FBC) on human tissue through use multiple sensing techniques by monitoring cerebrovascular activity and temperature. Intraoperative using a multimodality probe capable measuring temperature, electrocorticography (ECoG) changes in cerebral hemoglobin concentration was performed 13 patients with refractory epilepsy. Brain temperature neurovascular were measured beneath surrounding FBC device. Data categorized into three ranges...
Abstract In parkinsonism, subthalamic nucleus (STN) electrical deep brain stimulation (DBS) improves symptoms, but may be associated with side effects. Adaptive DBS (aDBS), which enables modulation of stimulation, limit effects, limited information is available about clinical effectiveness and efficaciousness. We developed a brain-machine interface for aDBS, parameters STN-DBS in response to γ2 band activity (80-200 Hz) local field potentials (LFPs) recorded from the primary motor cortex...
Activity patterns of projection neurons in the putamen were investigated behaving monkeys. Stimulating electrodes implanted chronically into proximal (MI ) and distal forelimb regions primary motor cortex (MI) region supplementary area (SMA). Cortical inputs to putaminal identified by excitatory orthodromic responses stimulation these cortices. Then, neuronal activity was recorded during performance a goal-directed reaching task with delay. Putaminal from MI SMA showed different patterns,...
The changes in neuronal firing activity the primary motor cortex (M1) and supplementary area (SMA) were compared monkeys rendered parkinsonian by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. dynamic was characterized using mathematical tools defined different frameworks (rate, oscillations or complex patterns). Then, for each cortical area, multivariate discriminate analyses further performed on these features to identify those important differentiate between normal...
In epilepsy treatment, besides medication and surgery, devices that modulate abnormal brain activity are being developed. Intracranial like vagus nerve stimulation (VNS), deep (DBS), cooling, drug delivery have seen significant advances in recent years. The process of developing these necessitates the use animals, from basic to applied research phases. Notably, with large-sized animals is vital provides insights closely mirror human responses. Cats, dogs, macaques frequently used models...