A5067867178- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Insect Resistance and Genetics
- Insect-Plant Interactions and Control
- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Tracheal and airway disorders
- Insect Pest Control Strategies
- Salivary Gland Tumors Diagnosis and Treatment
- Cellular transport and secretion
- Microtubule and mitosis dynamics
- Insect Pheromone Research and Control
- Graphene research and applications
- Lightning and Electromagnetic Phenomena
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Heat shock proteins research
- Magnetic Field Sensors Techniques
- Fatigue and fracture mechanics
- Adipokines, Inflammation, and Metabolic Diseases
- Pluripotent Stem Cells Research
- Head and Neck Surgical Oncology
- Lung Cancer Research Studies
- Plant and animal studies
- Neonatal Health and Biochemistry
Tokyo University of Pharmacy and Life Sciences
2024-2025
Waseda University
2019-2024
Japan Advanced Institute of Science and Technology
2022
Hokkaido University
2011-2021
The University of Tokyo
2008-2021
KAN Research Institute
2021
Tsumura Research Institute (Japan)
2015-2020
Japan Science and Technology Agency
2019
Whitehead Institute for Biomedical Research
2013-2017
Massachusetts Institute of Technology
2014-2015
Vascular plants appeared ~410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) lycophytes. We report here genome sequence lycophyte Selaginella moellendorffii (Selaginella), first nonseed vascular plant reported. By comparing gene content in evolutionarily diverse taxa, we found that transition from a gametophyte- to sporophyte-dominated life cycle required far fewer new genes than flowering plant, whereas secondary...
Mutation in Cu/Zn-superoxide dismutase ( SOD1 ) is a cause of familial amyotrophic lateral sclerosis (ALS). Mutant protein (SOD1 mut induces motor neuron death, although the molecular mechanism -induced cell death remains controversial. Here we show that specifically interacted with Derlin-1, component endoplasmic reticulum (ER)-associated degradation (ERAD) machinery and triggered ER stress through dysfunction ERAD. activated apoptosis signal-regulating kinase 1 (ASK1)-dependent pathway....
Significance Engineered human RBCs are attractive carriers for the introduction of novel therapeutics, immunomodulatory agents, and diagnostic imaging probes into body. Normal murine can be produced in tissue culture from progenitors; we have introduced genes these cells encoding surface proteins that covalently site-specifically modified on cell surface. The engineering labeling processes do not damage or affect their survival vivo. Most importantly, engineered labeled with a wide array...
Significance Immune-mediated diseases are prevalent, debilitating, and costly. Unfortunately, current treatments rely on nonspecific immunosuppression, which also shuts down a protective immune response. To circumvent this, we exploited the noninflammatory natural means of clearance red blood cells (RBCs), in combination with sortase-mediated RBC surface modification to display disease-associated autoantigens as RBCs’ own antigens. We found that this strategy holds promise for prophylaxis...
The ability of phagocytes to clear pathogens is an essential attribute the innate immune response. role signaling lipid molecules such as phosphoinositides well established, but membrane sphingolipids in phagocytosis largely unknown. Using a genetic approach and small molecule inhibitors, we show that Candida albicans requires intact sphingolipid biosynthetic pathway. Blockade serine-palmitoyltransferase (SPT) ceramide synthase-enzymes involved biosynthesis- by myriocin fumonisin B1,...
Cells possess ER quality control systems to adapt stress and maintain their function. ER-stress-induced pre-emptive (ER pQC) selectively degrades proteins via translocational attenuation during stress. However, the molecular mechanism underlying this process remains unclear. Here, we find that most newly synthesized endogenous transthyretin are rerouted cytosol without cleavage of signal peptide, resulting in proteasomal degradation hepatocytes Derlin family (Derlins), which ER-associated...
Roquin-2 promotes degradation of the kinase ASK1 to mediate an appropriate response oxidative stress and infection.
Abstract At the initial stage of carcinogenesis, when RasV12-transformed cells are surrounded by normal epithelial cells, RasV12 apically extruded from epithelia through cell competition with surrounding cells. In this study, we demonstrate that expression cyclooxygenase (COX)−2 is upregulated in Addition COX inhibitor or COX-2-knockout promotes apical extrusion Furthermore, production Prostaglandin (PG) E 2 , a downstream prostanoid COX-2, elevated and addition PGE suppresses mouse model,...
The NIAH 1102 strain of Megasphaera elsdenii utilized lactate in preference to glucose when the two substrates were present. Even was supplied cells fermenting glucose, switched substrate utilization from and did not utilize until decreased a low concentration (1 2 mM). Since shifted gradually without intermittence, typical diauxic growth seen. cyclic AMP content rise markedly with shift utilization, suggesting that this nucleotide is involved regulation shift. It unlikely propionate...
Several enveloped viruses exploit host pathways, such as the cellular endosomal sorting complex required for transport (ESCRT) machinery, their assembly and release. The influenza A virus (IAV) matrix protein binds to ESCRT-I complex, although involvement of early ESCRT proteins Tsg101 in IAV trafficking remain be established. We find that can facilitate trafficking, but this is effectively restricted by interferon (IFN)-stimulated ISG15. Cytosol from type I IFN-treated cells abolished...
Significance At the initial stage of carcinogenesis, transformation occurs in a single cell within epithelium. However, it is not clearly understood what happens at interface between newly emerging transformed cells and surrounding normal epithelial cells. Here, using mammalian culture zebrafish embryo systems, we demonstrate that Rab5, an important regulator endocytosis, accumulated endocytosis enhanced RasV12-transformed surrounded by The elevation disrupts E-cadherin–based cell–cell...
In epithelial tissues, adjacent normal cells recognize and eliminate transformed cells, maintaining tissue homeostasis. We have demonstrated that the interaction between MHC-I (Major Histocompatibility Complex Class I) on receptor AltR (Suboptimal Alteration Recognizing Protein) cell plays a central role in triggering elimination ability within cells. Moreover, previous reports suggested collective movement of surrounding including "non-adjacent peripheral cells" which are located further...
Despite the well-documented clinical significance of Warburg effect, it remains unclear how aggressive glycolytic rates tumor cells might contribute to other hallmarks cancer, such as bypass senescence. Here, we report that, during oncogene- or DNA damage–induced senescence, Pak1-mediated phosphorylation phosphoglycerate mutase (PGAM) predisposes enzyme ubiquitin-mediated degradation. We identify Mdm2 a direct binding partner and ubiquitin ligase for PGAM in cultured vitro. Mutations that...
Several lines of evidence have revealed that newly emerging transformed cells are often eliminated from the epithelium, though underlying molecular mechanisms this cancer preventive phenomenon still remain elusive. In study, using mammalian cell culture systems we identified plectin, a versatile cytoskeletal linker protein, as novel regulator for apical extrusion RasV12-transformed cells. Plectin is accumulated in RasV12 when they surrounded by normal epithelial Similarly, proteins tubulin,...