A5073353017- Memory and Neural Mechanisms
- RNA Interference and Gene Delivery
- Neural dynamics and brain function
- Occupational and environmental lung diseases
- Olfactory and Sensory Function Studies
- Extracellular vesicles in disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dendrimers and Hyperbranched Polymers
- Electrical Contact Performance and Analysis
- Immune cells in cancer
- Air Quality and Health Impacts
- MXene and MAX Phase Materials
- Neuroscience and Neuropharmacology Research
- RFID technology advancements
- MicroRNA in disease regulation
- Sleep and Wakefulness Research
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Traditional Chinese Medicine Studies
- Nanoparticle-Based Drug Delivery
- IPv6, Mobility, Handover, Networks, Security
Osaka City University
2024
Osaka Metropolitan University
2024
Nagoya City University
2022-2023
Osaka Prefecture University
2019-2021
Abstract Background As the application of silica nanomaterials continues to expand, increasing chances its exposure human body and potential harm are anticipated. Although toxicity is assumed be affected by their physio-chemical properties, including size surface functionalization, molecular mechanisms remain unclear. We hypothesized that analysis intracellular localization particles subsequent signaling could reveal a novel determinant inflammatory response against with different...
Although the etiology of major depressive disorder remains poorly understood, reduced gamma oscillations is an emerging biomarker. Olfactory bulbectomy, established model depression that reduces limbic oscillations, suffers from non-specific effects structural damage. Here, we show transient functional suppression olfactory bulb neurons or their piriform cortex efferents decreased oscillation power in areas and induced depression-like behaviors rodents. Enhancing transmission to structures...
The subiculum (SUB) plays a crucial role in spatial navigation and encodes navigational information differently from the hippocampal CA1 area. However, representation of subicular population activity remains unknown. Here, we investigated neuronal recorded extracellularly SUB rats performing T-maze open-field tasks. trajectory both areas was confined to low-dimensional neural manifolds homoeomorphic external space. conveyed position, speed, future path with higher decoding accuracy than CA1....
The antimicrobial protein CAP18 (approximate molecular weight: 18 000), which was first isolated from rabbit granulocytes, comprises a C-terminal fragment that has negatively charged lipopolysaccharide binding activity. In this study, we found (106-121)-derived (sC18)2 peptides have macropinocytosis-inducible biological functions. addition, these are highly applicable for use as extracellular vesicle (exosomes, EV)-based intracellular delivery, is expected to be next-generation drug delivery...
Delivery systems to lymph node-resident T cells around tumor tissues are essential for cancer immunotherapy, in order boost the immune responses. We previously reported that anionic dendrimers, such as carboxyl-, sulfonyl-, and phosphate-terminal were efficiently accumulated nodes via intradermal injection. Depending on terminal structure, their cell association properties different, carboxyl-terminal dendrimers did not associate with any majorly. In this study, we investigated delivery of...
Dendrimers with phenylalanine (Phe) and cyclohexanedicarboxylic acid (CHex) showed higher uptake into various cells including T via endocytosis. The cell association was enhanced under weak acidic conditions observed in tumor microenvironment.
Abstract Although the etiology of major depressive disorder remains poorly understood, impairment gamma oscillations recently emerged as a potential biomarker for depression. The olfactory bulb (OB) is source brain wide and bulbectomy an animal model Here we demonstrate that chemogenetic suppression OB neuronal activity or temporally suppressing to pyriform cortex synaptic transmission decreased oscillation power in multiple areas associated with depression-like behaviors. To assess...
Abstract BackgroundAs the application of silica nanomaterials continues to expand, increasing chances its exposure human body and potential harm are anticipated. Although toxicity is assumed be affected by their physio-chemical properties, including size surface functionalization, molecular mechanism remains unclear. ResultsWe employed a murine intratracheal instillation model amorphous nanoparticles (NPs) compare in vivo respiratory system. Pristine silica-NPs 50 nm diameters (50 nm-plain)...