A5062653919- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Cancer, Stress, Anesthesia, and Immune Response
- Molecular Sensors and Ion Detection
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Metabolism and Genetic Disorders
- Ubiquitin and proteasome pathways
- Species Distribution and Climate Change
- Cytomegalovirus and herpesvirus research
- Physiological and biochemical adaptations
- Vector-Borne Animal Diseases
- Animal Behavior and Reproduction
- Neurotransmitter Receptor Influence on Behavior
- Herpesvirus Infections and Treatments
- Metabolomics and Mass Spectrometry Studies
- Protein Degradation and Inhibitors
University Medical Center of the Johannes Gutenberg University Mainz
2023-2025
Johannes Gutenberg University Mainz
2023-2025
University of Szeged
2012-2023
MTA-SZTE Research Group on Artificial Intelligence
2014
Although the etiology of major depressive disorder remains poorly understood, reduced gamma oscillations is an emerging biomarker. Olfactory bulbectomy, established model depression that reduces limbic oscillations, suffers from non-specific effects structural damage. Here, we show transient functional suppression olfactory bulb neurons or their piriform cortex efferents decreased oscillation power in areas and induced depression-like behaviors rodents. Enhancing transmission to structures...
Abstract: Cortical spreading depression (CSD) involves a slowly-propagating depolarization wave in the cortex, which can appear numerous pathophysiological conditions, such as migraine with aura, stroke, and traumatic brain injury. Neurons glial cells are also depolarized transiently during phenomena. CSD is followed by massive increase glutamate release changes microcirculation. The aim of this study was to investigate effects two N -methyl-D-aspartate receptor antagonists, endogenous...
L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration L-KYN sulfate (L-KYNs) leads to rapid elevation neuroactive KP kynurenic acid (KYNA). An elevated level KYNA may have multiple effects on synaptic transmission, resulting in complex behavioral changes, such as hypoactivity or spatial working memory deficits. These results emerged from studies that focused rats, after low-dose L-KYNs treatment. However,...
The development of functionally interconnected networks between primary (S1), secondary somatosensory (S2), and motor (M1) cortical areas requires coherent neuronal activity via corticocortical projections. However, the anatomical substrate functional connections S1 M1 or S2 during early remains elusive. In present study, we used ex vivo carbocyanine dye (DiI) tracing in paraformaldehyde-fixed newborn mouse brain to investigate axonal projections neurons different layers barrel field (S1Bf),...
The Open Field (OF) paradigm is one of the most known primary behavioral tests to evaluate locomotion and exploration. Altered OF behaviour relatively simple observe, but understanding explaining reasons for observed changes a complex task. Generally, there are two factors, which determine behavior in this paradigm; one, positive exploratory drive originating from nature rodents explore new environments (for food shelter); two, animal avoiding open brightly lit spaces (exposure predators).OF...
Spike-and-wave discharges (SWDs), generated by the cortico-thalamo-cortical (CTC) network, are pathological, large amplitude oscillations and hallmark of absence seizures (ASs). SWDs begin in a cortical initiation network both humans animal models, including Genetic Absence Epilepsy Rats from Strasbourg (GAERS), where it is located primary somatosensory cortex (S1). The behavioral manifestation an AS occurs when spread site to whole brain, however, mechanisms behind this rapid propagation...
Aims Brain ischaemia models are essential to study the pathomechanisms of stroke. Our aim was investigate reliability and reproducibility our novel focal ischaemia‐reperfusion model. Methods To induce a cortical transient ischaemic attack, we lifted distal middle cerebral artery ( MCA ) with special hook. The early changes after 2 × 15‐min occlusion were observed in somatosensory evoked responses SERs ). histological 30‐, 45‐ or 60‐min examined 1‐day survival period by...