A5076947828- Nutrition and Health in Aging
- Antibiotics Pharmacokinetics and Efficacy
- Frailty in Older Adults
- Dysphagia Assessment and Management
- Antibiotic Resistance in Bacteria
- Reproductive Biology and Fertility
- Pneumonia and Respiratory Infections
- Sperm and Testicular Function
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cerebral Palsy and Movement Disorders
- Cardiac Health and Mental Health
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Heart Failure Treatment and Management
- Antimicrobial Resistance in Staphylococcus
- Medical Practices and Rehabilitation
- Trauma and Emergency Care Studies
- Clinical Nutrition and Gastroenterology
- Receptor Mechanisms and Signaling
- Body Composition Measurement Techniques
- Enzyme function and inhibition
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and genetic disorders
- Nosocomial Infections in ICU
National Hospital Organization Takamatsu Medical Center
2012-2024
Kagawa University
2021
Tokyo Women's Medical University
1999-2006
University of Hawaii System
2006
Biogen (United States)
2006
Toho University
1992-2001
National Institute for Physiological Sciences
1999-2001
National Cerebral and Cardiovascular Center
1999-2000
Yamasa Corporation (Japan)
1996
Aichi Developmental Disability Center
1979
The condition of muscle fiber atrophy and weakness that occurs in respiratory muscles along with systemic skeletal age is known as sarcopenia. Japanese Working Group Respiratory Sarcopenia the Association Rehabilitation Nutrition narratively reviews these areas, proposes concept diagnostic criteria. We have defined sarcopenia "whole-body low mass followed by strength and/or function." can be caused various factors such aging, decreased activity, undernutrition, disease, cachexia, iatrogenic...
Upon fertilization the hamster egg shows transient, periodic hyperpolarizing responses (h.r.s) due to a Ca‐activated K conductance; these are superimposed on gradual, shift of resting potential (h.s.) (Miyazaki & Igusa, 1981a, 1982a). The h.r.s and h.s. were further analysed by changing external divalent cations or injection Ca2+ into egg, study mechanisms increase in intracellular concentration ([Ca2+]i). series was abolished removal Ca2+. frequency h.r. decreased lowering [Ca2+]o...
We defined respiratory sarcopenia as a coexistence of muscle weakness and decreased mass. Although function is indispensable for life support, its evaluation has not been included in the regular assessment or adequately evaluated clinical practice. Considering this situation, we prepared position paper outlining basic knowledge, diagnostic methods, mechanisms, involvement diseases, intervention treatment future perspectives on sarcopenia, summarized current consensus sarcopenia. Respiratory...
Several patients undergoing physical therapy have nutritional problems. Knowledge of nutrition is necessary for addressing problems, such as malnutrition, sarcopenia, frailty, and cachexia. However, the relationship between not fully understood. Physical plays an important role in management, evaluations, muscle strength mass play screening diagnosis. Exercise, core therapy, essential interventions. recent studies suggested that a combination interventions can maximize function, activity,...
Background Idiopathic pulmonary fibrosis (IPF) is characterised by worsening dyspnoea and exercise intolerance. Research question Does a long-term rehabilitation improve tolerance in patients with IPF treated standard antifibrotic drugs, which are expected to reduce disease progression? Methods This open-label randomised controlled trial was performed at 19 institutions. Stable receiving nintedanib were into control groups (1:1). The group underwent initial included twice-weekly sessions of...
<h3>OBJECTIVE</h3> To elucidate whether prognosis after acute myocardial infarction can be predicted by measuring plasma adrenomedullin, a novel vasorelaxant peptide. <h3>PATIENTS AND DESIGN</h3> Plasma adrenomedullin concentrations on day 2 were measured in 113 patients with other clinical and haemodynamic variables related to mortality. <h3>RESULTS</h3> During mean follow up period of 25 months, 16 died cardiac causes. increased significantly compared controls (mean (SD), 12.3 (8.8)...
Aim Patients awaiting abdominal surgery are often malnourished, which puts them at a high risk of postoperative complications. The aim the present study was to investigate effects preoperative nutritional status using Geriatric Nutritional Risk Index (GNRI) on complications and course recovery for patients undergoing surgery. Methods In this prospective multicenter cohort study, we enrolled from November 2015 December 2017. characteristics were compared between participants (median age 71...
Elderly patients awaiting lung resection surgery often have poor physical function, which puts them at a high risk of postoperative pulmonary complications. The aim this study was to investigate the impact preoperative performance on complications in surgery. In prospective multicenter cohort study, characteristics and were compared between subjects with low (<10) (≥10) Short Physical Performance Battery (SPPB) scores. Postoperative defined as over grade II Clavien-Dindo classification...
Nutritional disorders diminish the effectiveness of physical therapy. The pathogenesis nutritional disorders, such as sarcopenia, frailty, and cachexia, differs from disease to disease. Disease-specific nutrition can maximize function, activity, participation, quality life for patients undergoing therapy, a practice known Understanding practicing disease-specific therapy is essential meet patients' diverse needs goals with any Thus, therapist division Japanese Association Rehabilitation...
RP 59500 was more potent than erythromycin, josamycin, amoxycillin and ciprofloxacin, as vancomycin, against staphylococci enterococci. Against streptococci, the activity of very similar to that amoxycillin, but superior vancomycin or ciprofloxacin. Compared with other antimicrobial agents tested, most active erythromycin-resistant Gram-positive cocci.
This murine model of nontypeable (unencapsulated) Haemophilus influenzae (NTHI) bronchopneumonia used organisms bound to mouse fetal lung (MFL) cells as an inoculum. Pretreatment the mice with 40 microL 1% formalin 3 days before intranasal instillation bacteria was necessary allow infection. The number NTHI recovered from lungs plus trachea on day 7 after >100 times originally inoculated. Later, however, diminished gradually, and by 14 it almost identical original inoculum size. Serum IgM...
Strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis (CF) never spread systemically. This may be due to serum sensitivity since these strains are very sensitive complement-mediated bactericidal activity. A serum-resistant mutant, P. TUM3 HSR, was obtained serum-sensitive strain a CF patient in order clarify the mechanism failure systemic spread. LPS profiles on silver-stained gels and immunological analysis revealed that long O-polysaccharide side chain overproduced...
AM-1155, a novel fluoroquinolone, exhibited potent activity against Streptococcus pneumoniae, including penicillin-resistant strains; the MIC90 for 48 clinical isolates was 0.25 mg/L. The antibacterial of AM-1155 S. pneumoniae higher than that levofloxacin (MIC90 1 mg/L) and comparable with sparfloxacin. MIC90s penicillin G erythromycin were 2 > 4 mg/L, respectively. showed no cross-resistance to or erythromycin. For experimental murine pneumonia intermediately resistant penicillin, oral...
E1077, a new injectable cephalosporin with broad antibacterial spectrum and potent activity, was evaluated for its in vitro vivo activities comparison those of cefpirome, cefuzonam, ceftazidime, cefotaxime. E1077 showed activity against gram-positive gram-negative bacteria. Against methicillin-susceptible Staphylococcus aureus, as active cefpirome; the MIC 90% strains tested (MIC90) 1.0 microgram/ml. methicillin-resistant S. less (MIC90, 64 micrograms/ml). For Enterobacter cloacae...
Azithromycin is an azalide with potent activity against Haemophilus influenzae including ampicillin-resistant strains. We evaluated the efficacy of azithromycin, clarithromycin and three beta -lactams when used for 1 day only 3 days treatment a murine model bronchopneumonia, using strains H. influenzae, two which were ampicillin resistant. MICs azithromycin (1-2 mg/L) (4-8 similar The cefdinir cefcapene beta-lactamase-negative (BLNAR) 32 times higher than those beta-lactamase-positive...
Aim Skeletal muscle mass is associated with exercise tolerance in patients chronic heart failure (CHF). Anthropometric indicators are used to evaluate skeletal mass, as these can be easily assessed clinical practice. However, the association between anthropometric and unclear. This study aimed investigate CHF patients. Methods We evaluated 69 CHF. Mid‐arm circumference, mid‐arm circumference (MAMC), calf body index were measured indicators. Exercise was according peak oxygen uptake (VO 2 )....
Interoception is the sensing function of physiological conditions and crucial in self-regulation decision-making. We examined association heartbeat tracking task performance, an indicator interoceptive accuracy, with degree improvement exercise tolerance patients undergoing home-based cardiac rehabilitation.Participants underwent baseline peak oxygen uptake (VO2) measurements a task. The score varies between 0 1, higher scores indicating better perception. After 6 months training, VO2 was...