Chang‐Hun Lee

ORCID: 0000-0002-3806-1170
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About
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Research Areas
  • Plasmonic and Surface Plasmon Research
  • Advanced Fluorescence Microscopy Techniques
  • Near-Field Optical Microscopy
  • Skin and Cellular Biology Research
  • Cellular Mechanics and Interactions
  • Photonic and Optical Devices
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Particle physics theoretical and experimental studies
  • Hair Growth and Disorders
  • Bullying, Victimization, and Aggression
  • Ion Channels and Receptors
  • Advanced Biosensing Techniques and Applications
  • Advanced biosensing and bioanalysis techniques
  • Neutrino Physics Research
  • Liquid Crystal Research Advancements
  • Genomics and Chromatin Dynamics
  • Policing Practices and Perceptions
  • Dermatological and Skeletal Disorders
  • Optical Coatings and Gratings
  • Child and Adolescent Psychosocial and Emotional Development
  • Bone Tissue Engineering Materials
  • Bacterial biofilms and quorum sensing
  • Enzyme Structure and Function
  • Psychosocial Factors Impacting Youth
  • Surface Modification and Superhydrophobicity

Daegu Gyeongbuk Institute of Science and Technology
2015-2025

Yonsei University
2004-2024

Institute of Science and Technology
2024

Government of the Republic of Korea
2024

University of Essex
2022

Johns Hopkins University
2005-2020

University of Maryland, College Park
2017-2020

National Tsing Hua University
2019

City, University of London
2019

Hannam University
2012-2014

Histamine provokes itching and is a major skin disease complaint. known to excite subset of sensory neurons, predominantly C-fibers. Although histamine pruritogenic, its signaling pathways that neurons have not been identified. Because the metabolic products lipoxygenases (LOs) activate transient receptor potential vanilloid receptor-1 (TRPV1) in we hypothesized excites by activating TRPV1 via phospholipase A 2 (PLA ) LO stimulation. In cultured evoked inward currents were reduced...

10.1523/jneurosci.4643-06.2007 article EN cc-by-nc-sa Journal of Neuroscience 2007-02-28

The influx of genomic sequence information has led to the concept structural proteomics, determination protein structures on a genome-wide scale. Here we describe an approach proteomics small proteins using NMR spectroscopy. Over 500 from several organisms were cloned, expressed, purified, and evaluated by NMR. Although there was variability among proteomes, overall 20% these found be readily amenable structure determination. sample preparation centralized in one facility, distributive used...

10.1073/pnas.042684599 article EN Proceedings of the National Academy of Sciences 2002-02-19

The aim of this study is to identify an ecological prediction model bullying behaviors. Based on systems theory, identifies significant factors influencing behaviors at different levels middle and high school. These include the microsystem, mesosystem, exosystem, macrosystem. More specifically, investigated in multilevel analysis are individual traits, family experiences, parental involvement, school climate, community characteristics. Using data collected 2008 from 485 randomly selected...

10.1177/0886260510370591 article EN Journal of Interpersonal Violence 2010-06-03

Abstract Sanshools are major active ingredients of Zanthoxylum piperitum and used as food additives in East Asia. cause irritant, tingling sometimes paresthetic sensations on the tongue. However, molecular mechanism underlying pungent or sensation induced by sanshools is not known. Because many transient receptor potential (TRP) channels responsible for various spices additives, we expressed 17 TRP human embryonic kidney (HEK) cells investigated their activation hydroxy‐α‐sanshool (HαSS)...

10.1111/j.1460-9568.2007.05743.x article EN European Journal of Neuroscience 2007-08-29

Pain is an unpleasant sensation experienced when tissues are damaged. Thus, pain in some way protects body from imminent threat or injury. Peripheral sensory nerves innervated to peripheral initially respond multiple forms of noxious strong stimuli, such as heat, mechanical and chemical stimuli. In response these electrical signals for conducting the nociceptive neural through axons generated. These action potentials then conveyed specific areas spinal cord brain. Sensory afferent fibers...

10.1016/s1016-8478(23)25242-5 article EN cc-by-nc-sa Molecules and Cells 2005-12-01

Keratins, the largest subgroup of intermediate filament (IF) proteins, form a network 10-nm filaments built from type I/II heterodimers in epithelial cells. A major function keratin IFs is to protect cells mechanical stress. Like filamentous actin, must be cross-linked vitro achieve high level resilience characteristic live Keratins 5 and 14 (K5 K14), main pairing occurring basal progenitor layer epidermis related epithelia, can readily self-organize into large bundles vivo. Here, we show...

10.1083/jcb.200810196 article EN cc-by-nc-sa The Journal of Cell Biology 2009-08-03

This study simultaneously investigates personal and interpersonal traits that were found to be important factors of bullying behavior using data collected from 1,238 randomly selected Korean middle school students. Using a modified expanded definition based on more culturally sensitive approach bullying, this categorizes bullies into three groups: Type I (minor-covert-nonchronic bullying), II (moderate-covert-chronic or severe-overt-nonchronic III (severe-overt-chronic bullying). In...

10.1177/0886260508329124 article EN Journal of Interpersonal Violence 2009-02-27

This study uses an ecological systems theory to understand bullying behavior. Emphasis is given overcome limitations found in the literature, such as very little empirical research on functions of parental involvement and impacts school climate outcome variable. Two investigated are (a) bridging negative experiences within family with behaviors at schools, (b) influencing climate. Bullying were measured by a modified Korean version Olweus’ bully/victim questionnaire (reliability range:...

10.1177/0886260511433508 article EN Journal of Interpersonal Violence 2012-02-10

Precise measurement and control of local heating in plasmonic nanostructures are vital for diverse nanophotonic devices. Despite significant efforts, challenges understanding temperature-induced nonlinearity persist, particularly light absorption near-field enhancement due to the absence suitable techniques. This study presents an approach allowing simultaneous measurements through angle-resolved scanning optical microscopy with iterative opto-thermal analysis. We revealed gold thin films...

10.1021/acs.nanolett.3c04420 article EN Nano Letters 2024-02-26

<title>Abstract</title> Erythropoietin (EPO) is a glycoprotein that stimulates red blood cell production in the bone marrow and protects neurons from oxidative stress, making it potential treatment for various neurological diseases. However, EPO analogs often lead to side effects like excessive erythropoiesis tumor growth. In this study, we aimed develop ML1-R, peptide derived C-helix of EPO, enhance neuroprotection while minimizing adverse effects. By modifying amino acids interact with...

10.21203/rs.3.rs-5779616/v1 preprint EN cc-by Research Square (Research Square) 2025-01-08

In this Letter, we describe spatially switched surface plasmon microscopy (ssSPM) based on two-channel momentum sampling. The performance evaluated with periodic nanowires in comparison conventional SPM and bright-field shows that the resolution of ssSPM is enhanced by almost 15 times over SPM. provides an extremely simple way to attain diffraction limit go beyond for super-resolution label-free techniques.

10.1364/ol.43.000959 article EN Optics Letters 2018-02-14

Purpose This study aims to develop and test a theoretical model postulating that hotel customer’s brand attachment is reinforced by positive negative switching barriers, which, in turn, determine customer citizenship behaviour (CCB) towards brands. Design/methodology/approach Surveys were conducted completed 233 respondents the USA who had favourite brands used these previous year. A framework was developed based on literature, eight hypotheses tested using structural equation modelling....

10.1108/ijchm-10-2021-1280 article EN International Journal of Contemporary Hospitality Management 2022-06-15

Abstract Biofilm formation is one of the leading causes complications after surgery in clinical settings. In this study, we profiled biofilm-forming ability various periprosthetic infection-associated pathogens on medically relevant surfaces, polystyrene (PS) and titanium (Ti). We also explored how a specific environmental stressor, epigallocatechin gallate (EGCG), affected biofilm formation. First, Congo red tests revealed that all microorganisms formed biofilms within 72 h. Then, amounts...

10.1038/s41598-022-22929-z article EN cc-by Scientific Reports 2022-11-04

Chk2 is a kinase critical for DNA damage-induced apoptosis and considered tumor suppressor. essential p53 transcriptional apoptotic activities. Although mutations of are present in more than half all tumors, cancers rare, suggesting that may be inactivated by unknown alternative mechanisms. Here we elucidate one such mechanism regulated PML (promyelocytic leukemia) involved acute promyelocytic leukemia (APL). p53-inactivating extremely rare APL, t(15;17) chromosomal translocation which fuses...

10.1074/jbc.m604391200 article EN cc-by Journal of Biological Chemistry 2006-07-12

This paper presents a sensor-data-fusion method using an Unscented Kalman Filter (UKF), to implement accurate localization system for mobile robots. Integration of data from various sensors efficient sensor fusion algorithm is required achieve continuous and We use low cost accelerometer, gyroscope, encoders obtain robot motion information. The UKF, used as algorithm, advanced filtering technique which outperforms the widely-used Extended (EKF) in many applications. able compensate slip...

10.1109/iccas.2010.5669779 article EN ICCAS 2010 2010-10-01
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