Therapeutic approach of Alzheimer's disease (AD) has been gradually diversified. We examined the therapeutic and preventive potential andrographolide, which is a lactone diterpenoid from Andrographis paniculata, focused on Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects inhibitory activity amyloid beta (Aβ)42-induced microglial activation related to Nrf2 nuclear κB (NF-κB)-mediated inflammatory...

PTP1B deficiency in mouse mammary tumor virus (MMTV)-NeuNT transgenic mice inhibited the onset of MMTV-NeuNT-evoked breast cancer, while its overexpression was observed cancer. Thus, inhibitors are considered chemopreventative agents for As part our program to find inhibitors, one new diterpene glycoside (1) and 13 known compounds (2-14) were isolated from methanol extract stems Akebia quinata. All isolates identified based on extensive spectroscopic data analysis, including UV, IR, NMR MS....

This study investigates the inhibitory effects of polymethoxyflavones (PMFs) on enzymes involved in production trimethylamine (TMA) and trimethylamine-N-oxide (TMAO). PMFs were isolated from Valencia orange peel identified using column separation NMR techniques. The findings reveal that nobiletin 3,6,7,8,2′,5′-hexamethoxyflavone significantly suppress cntA/B cutC/D, respectively. Furthermore, decreases level TMAO formation by suppressing FMO3 mRNA level. elucidates specific structural...

Porcine epidemic diarrhea virus (PEDV), a serious swine epidemic, has been rampant in Asia since the 1990s. Despite widespread use of PEDV vaccines, occurrence variants requires discovery new substances that inhibit these viruses. During search for inhibitory materials from natural sources, seven sabphenosides (1–7) and flavonoid (8), as well eight known phenolic compounds (9–16), were obtained leaves Sabia limoniacea. The structural determination derivatives (1–8) was accomplished using...

During an effort to find insulin mimetic compounds, the leaves of Gymnema inodorum were shown have a stimulatory effect on glucose uptake in 3T3-L1 adipocyte cells. Bioassay-guided fractionation 70% ethanol extract G. was applied yield two new (1 and 2) known (8 9) oleanane triterpenoids with methyl anthranilate moiety together five further (3–7). The chemical structures all isolates determined based their spectroscopic data, including IR, UV, NMR, mass spectrometric analysis. isolated...

Alzheimer's disease (AD), a neurocognitive impairment affecting human mental capacity, is related to the accumulation of amyloid-β peptide (Aβ) and hyperphosphorylation tau protein. In addition modern therapies approved for AD treatment, natural products with antioxidant anti-inflammatory properties have been studied their potential prevent pathogenesis. Six new noroleanane triterpenoids from fruit peels Camellia japonica were isolated, structures determined by diverse spectroscopic methods....

Using molecular networking-guided isolation, three new galloyl ester triterpenoids (1–3), two hexahydroxydiphenic acid-conjugated (6 and 7), four known compounds (4, 5, 8, 9) were isolated from the fruits leaves of Castanopsis sieboldii. The chemical structures 1–3, 6, 7 elucidated on basis interpreting their NMR, HRESIMS, ECD spectra. All (1–9) evaluated for glucose uptake-stimulating activities in differentiated adipocytes using 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-d-glucose...

Humulus japonicus is an annual plant belonging to the Cannabacea family, and it has been traditionally used treat pulmonary tuberculosis, dysentery, chronic colitis, hypertension. We investigated active components against Parkinson’s disease from H. fraction (HJF) using high performance liquid chromatography (HPLC) coupled with quadruple-time-of-flight mass spectroscopy (qTOF-MS) NMR. Fourteen compounds were isolated HJF, including one new compound, HPLC-qTOF-MS The major of HJF...

Bitter substances in functional foods and beverages can act as nutraceuticals, offering potential health benefits. However, their unpleasant sensory impact reduces the consumption of these foods. Consequently, discovery bitter masking compounds is crucial for enhancing intake bioactive beverages. taste mediated by TAS2Rs, a sub-family G-protein-coupled receptors. TAS2R14 especially pivotal perception bitterness, it one most broadly tuned In this study, allspice was extracted purified to...

Humulus japonicus (HJ) is a widely used herbal medicine in Asia with anti‑oxidative, anti‑microbial, and anti‑inflammatory effects. We investigated the potential therapeutic effects of HJ rheumatoid arthritis (RA) using mouse model collagen‑induced (CIA) lipopolysaccharide‑stimulated murine macrophage cell line (RAW 264.7). The CIA mice were administered 300 mg/kg orally starting 3 days prior to second immunization. clinical histopathological findings assessed paw mice. levels autoantibodies...

Sicyos angulatus (SA), a summer annual vine originating from Northeastern USA, is widely distributed noxious invasive plant. However, the clinical application of SA has not been investigated previously. The purpose present study was to determine effects on atherosclerosis and its underlying mechanism. Atherosclerosis induced by feeding apolipoprotein E-deficient (apoE-/-) mice with an atherogenic diet for 8 weeks. administered daily oral gavage during induction atherosclerosis. ApoE-/-...

Melicope pteleifolia has long been consumed as a popular vegetable and tea in Southeast Asian countries, including Malaysia southern mainland China, is effective the treatment of colds inflammation. In search for active metabolites that can explain its traditional use an antipyretic, six new phloroacetophenone derivatives (3–8) along with seven known compounds (1, 2, 9–13) were isolated from leaves M. pteleifolia. Their chemical structures confirmed by extensive spectroscopic analysis NMR,...

We aimed to investigate the effect of Sicyos angulatus (SA) ethanolic extracts as antioxidants and potential treatments for liver disease.To establish a mouse model injury, C57BL/6 male mice were injected via caudal vein with single dose concanavalin A (Con A, 15 mg kg-1). SA administered once by oral gavage 30 min before Con injection.In vitro studies showed that decreased tert-butyl hydroperoxide (t-BHP)-induced reactive oxygen species (ROS) production. administration reduced plasma...

Obesity is a medical condition in which excess body fat has accumulated to serious extent.It chronic disease that can lead dyslipidemia, insulin resistance, and type 2 diabetes.In the present study, we investigated anti-obesity effects of Sicyos angulatus (SA) extract on high-fat diet (HFD)-induced C57BL/6J obese mice.The mice were divided into vehicle three SA groups (25, 50, 100 mg/kg weight).The fed HFD with or without for 12 weeks.The oral administration reduced adipose tissue weight...

As a type of contact dermatitis (CD), irritant CD (ICD) is an acute skin inflammation caused by external irritants, such as soap, water and chemicals. Humulus japonicus (HJ) herbal medicine widely distributed in Asian countries has anti-inflammatory, antimicrobial antioxidant effects. The current study aimed to investigate the anti-dermatitis effect HJ on ICD determine molecular basis this using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mice models lipopolysaccharide...

The major class of bioactive metabolites in Gymnema sylvestre, a popular Ayurvedic medicinal plant for the treatment diabetes mellitus, is oleanane triterpenoids. In this study, targeted, biosynthesis-inspired approach using UHPLC-qTOF/MS was implemented to elucidate whole chemical profile standardization Vietnamese G. sylvestre variety. known compounds were first determined identify building blocks biosynthetic intermediates and construction rules synthesizing triterpenoids plant. These...

Ten phenolic constituents, including three new macrocyclic glycosides (

Diabetes mellitus is characterized by hyperglycemic due to impaired insulin secretion or resistance. In our search for anti-diabetic agents, we found that a 70% EtOH extract of Rubus cochinchinensis (Tratt) enhances glucose uptake in 3T3-L1 adipocytes. R. predominantly East Asia, particularly Vietnam, Laos, Cambodia, and southern China. Despite its widespread distribution, there have been few studies on bioactivity chemical constituents. this study, activity-guided fractionation from the...

The plant Allium hookeri, belonging to the genus, has a history of being used both as common food ingredient and in herbal medicine. It recently been reported have anti-oxidant anti-inflammatory effects. A. hookeri also shown exhibit neuroprotective anti-neuroinflammatory activities, but active compounds responsible for these effects not identified previous studies. This study aimed perform metabolite profiling using an HRESI-qTOF MS/MS-based molecular networking approach identify from that...