A5002087247- Synthesis and biological activity
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer-related gene regulation
- X-ray Diffraction in Crystallography
- Signaling Pathways in Disease
- Crystallization and Solubility Studies
- Ubiquitin and proteasome pathways
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Caveolin-1 and cellular processes
- Crystal structures of chemical compounds
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- ATP Synthase and ATPases Research
- Cancer therapeutics and mechanisms
- Genomics, phytochemicals, and oxidative stress
- Galectins and Cancer Biology
- Phytochemistry Medicinal Plant Applications
- Cancer, Lipids, and Metabolism
South Asian University
2016-2024
Turku Centre for Computer Science
2019
University of Turku
2013-2019
Åbo Akademi University
2013-2019
UNSW Sydney
2013
University of Helsinki
2013
Tampere University Hospital
2013
Institute for Molecular Medicine Finland
2013
Tampere University
2013
Turku Centre for Biotechnology
2013
The fabrication of metal nanoparticles through green synthetic pathways using plant extracts has increased attention due to low cost, benevolent methods, fewer hazardous byproducts, and applications. Silver (AgNPs) were synthesized by reacting aqueous root Rubus ellipticus Sm. (RERE) with AgNO 3 solution (1 mM) at an ambient condition. visual change color from light yellow reddish brown the absorption peak 416‐420 nm in UV‐visible spectra indicated formation AgNPs solution. shifting...
Plants have long been considered as a basis of medicines for different indigenous cultures around the globe. They continue prominent source important phytoconstituents which exhibit significant biological activities. In this study, we performed phytochemical screening, estimation total phenolic and flavonoids, antioxidants, antimicrobial activities stem bark Beilschmiedia roxburghiana Nees using solvents. The flavonoid contents ranged from 106.73 ± 1.62 mg GAE/g 99.32 0.66 QE/g (methanol...
Atherosclerosis is main cause of arteriosclerosis. The pivotal role low-density lipoprotein (LDL) oxidation in atherogenesis suggests antioxidants may help prevent cardiovascular disease. Fraxinus rhynchophylla DENCE (Oleaceae) a traditional medicinal plant from East Asia. During the course characterizing potential drug candidates natural products, we isolated two major coumarins, esculetin and fraxetin found that has dual-antioxidative functions. Low concentrations (1-5 microM) potently...
Abstract Checkpoint kinase Chk1 is constitutively active in many cancer cell types and new generation inhibitors show marked antitumor activity as single agents. Here we present a hitherto unrecognized mechanism that contributes to the response of cells Chk1-targeted therapy. Inhibiting chronic induced tumor suppressor protein phosphatase 2A (PP2A), which by dephosphorylating MYC serine 62, inhibited impaired survival. Mechanistic investigations revealed inhibition activated PP2A decreasing...
Abstract Breast cancer is one of the most common cancers with a high mortality rate, underscoring need to identify new therapeutic targets. Here we report that non-POU domain-containing octamer-binding (NONO) protein overexpressed in breast and validated interaction WW domain PIN1 c-terminal threonine-proline (thr-pro) motifs NONO. The NONO increases stability by inhibiting its proteasomal degradation, this identifies as positive regulator promoting tumor development. Functionally, silencing...
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation in joints and subsequent destruction of cartilage bone. Inflammatory mediators such as PGs proinflammatory cytokines contribute to RA progress. Pin1, a peptidyl prolyl isomerase, plays important pathophysiological roles several diseases, including cancer neurodegeneration. We found that both Pin1 cyclooxygenase-2 (COX-2) were highly expressed ankle tissues type II collagen-induced mice. HTB-94...
Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play a key role in the inflammatory processes. Improper overproduction of NO prostaglandins by both enzymes are also believed to be involved pathogenesis certain human cancers. Crude extracts Selaginella tamariscina used as an oriental medicine, which has been reported inhibit production proinflammatory cytokines cause cell cycle arrest. We isolated 2′,8″-biapigenin from S. investigated whether it modulates iNOS COX-2...
Typically chemopreventive agents either induce phase II detoxifying enzymes or inhibit the cytochrome P450 (CYPs) that are required for metabolism of carcinogens. In this study, we isolated a coumarin compound, isoimperatorin from Poncirus trifoliata Raf., and studied its protective effects against aflatoxin B1 (AFB1)-induced cytotoxicity in H4IIE cells. Isoimperatorin (>0.3 microM) significantly inhibited cytotoxic effect AFB1. CDNB [1-chloro-2,4-dinitrobenzene; glutathine S-transferase...
MCF-7/ADR cells, a doxorubicin-resistant human breast cancer cell line, acquires resistance to several chemotherapeutic agents, such as anthracylines and taxol, via overexpression of the multidrug resistance1 (MDR1) gene. The present study was designed clarify whether ginsenosides affect expression MDR1 gene in cells. Ginsenoside Rd, Re, Rb1, Rg1 (100 μ g/ml) decreased protein levels In particular, ginsenoside Rd most potently inhibited without cytotoxicity, but did not change mRNA or...
Medicinal plants have been known to treat simple life-threatening diseases in different communities of Nepal for many years. This study aims analyze the phytochemicals as plant secondary metabolites, evaluate antioxidant and antibacterial activities Rubus ellipticus, Ziziphus mauritiana, Pyrus pashia, Drynaria coronans extracts that are commonly being used traditional medicine. Phytochemical analysis was performed investigate plant's metabolites such polyphenols, alkaloids, flavonoids,...
5-Nitroisatin-4-(1-(2-pyridyl)piperazinyl)-3-thiosemicarbazone (Nitistpyrdlpz) and its Cu(II) complex were synthesized characterized by CHN thermal analysis spectroscopic measurements viz. UV-vis, FTIR, 1H NMR, 13C ESI-HRMS, PXRD EPR. In the complex, copper(II) ion is coordinated terdentate thiosemicarbazone anion one chloride in a distorted square planar geometry. The compounds against breast cancer cell lines; MCF-7 MDA-MB-231 epidermoid carcinoma; A431 showed that contributed to reduce...
A series of novel thiosemicarbazone derivatives containing 5-methoxy isatin were designed and synthesized with modification on N(4) position. Derivatives considering structure-activity relationship have been by condensing thiosemicarbazide isatin. The compounds characterized elemental analysis, FT-IR spectroscopy, UV-visible NMR (1H, 13C) mass spectrometry, a single-crystal study. Biological evaluation the revealed that MeOIstPyrd is most promising compound against skin cancer cell line,...
Abstract Micro‐organism resistance to the drugs has made it necessary explore novel antibacterial that have significant toxicities. Herein, we report bioconjugates of N‐acetyl‐D‐glucosamine with benzothiazole derivatives via ester linkage, which display potent effect against pathogenic micro‐organisms (E. coli, S. aureus and C. albicans). These newly synthesized compounds also been evaluated for anticancer ( Hep‐2 caco cell lines) antioxidant activities. The results supported suppress...
Zinc(II) complexes of 3-hydroxy-2-formylpyridine N(4)-methylthiosemicarbazone (1) and N(4)-pyrrolidinyl thiosemicarbazone (2) respectively have been synthesized characterized by elemental analysis, IR, UV–Vis, 1H NMR spectroscopy mass spectrometry. These compounds were investigated for their antiproliferative potential against PC3 (Prostate Cancer), DU145 A549 (Lung A431 (skin cancer) Hela (Cervical Cancer cell) cell lines. All the showed good activity tested However, compound HHyPyPyrd...