A5018464798- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Crystallization and Solubility Studies
- Crystal structures of chemical compounds
- X-ray Diffraction in Crystallography
- Synthesis of Tetrazole Derivatives
- Landslides and related hazards
- Phytochemistry and Bioactive Compounds
- Cancer Mechanisms and Therapy
- Magnetism in coordination complexes
- Computational Drug Discovery Methods
- Organometallic Compounds Synthesis and Characterization
Tribhuvan University
2020-2025
Phytochemical screening of Calotropis procera (Aakh, Milkweed) leaf and stem extracts was performed using solvents: hexane, benzene, dichloromethane, methanol distilled water. zAlkaloids, carbohydrates, reducing sugar, tannins, phenolic compounds, gum mucilage, flavonoids, quinines, coumarin were all present. At a concentration 20 g/mL, the methanolic extract demonstrated good antibacterial action against two bacteria: gram-positive Bacillus subtilis gram-negative Escherichia coli, as well...
5-Nitroisatin-4-(1-(2-pyridyl)piperazinyl)-3-thiosemicarbazone (Nitistpyrdlpz) and its Cu(II) complex were synthesized characterized by CHN thermal analysis spectroscopic measurements viz. UV-vis, FTIR, 1H NMR, 13C ESI-HRMS, PXRD EPR. In the complex, copper(II) ion is coordinated terdentate thiosemicarbazone anion one chloride in a distorted square planar geometry. The compounds against breast cancer cell lines; MCF-7 MDA-MB-231 epidermoid carcinoma; A431 showed that contributed to reduce...
A series of N(4) thiomorpholinyl isatin/5-haloisatin thiosemicarbazones and their copper(II) complexes ( 1-8 ) were prepared characterized by elemental analysis, NMR, IR, ESI-HRMS, UV-Visible, EPR, TGA powder single crystal X-ray diffraction studies. The possess distorted square planar geometry. study compounds 1-3 confirmed existence in thione tautomeric form. vitro aniproliferative the against cancer cells MCF-7, A431 normal cell PNT2 showed significant antiproliferative activity for both...
A series of N(4) dimethyl isatin thiosemicarbazones(1-4) and their copper(II) complexes (5-8) have been synthesized characterized by elemental analysis spectroscopic techniques (IR, NMR, ESI-HRMS, UV-Vis). The thermo gravimetric (TGA) confirmed existence in anhydrous form thermal stability air. PXRD pattern the suggested monoclinic crystal system with P 1211 21 symmetry. possess distorted square planar geometry chelation to Cu(II) ion via terdentate thiosemicarbazone one chloride ion. EPR...
A series of pyrazole derivatives (2a-m) was synthesized by the reaction pongamol with various hydrazines (1a-m) derivatives. All pyrazoles were screened for their anticancer potential against breast carcinoma (MCF7, MDA-MB-231), ovarian (SKOV3) HeLa cervical cancer cells, and HEK293 MCF10A normal cells. Among 13 compounds, seven compounds PONG, 2j, 2k, 2e, 2m, 2h, 2g found to have more than 50% cell inhibition. Docking study also performed enzyme CYP1A1 using SWISS DOCK.. KEYWORDS :CYP1A1,...
A series of N(4) thiomorpholinyl isatin/5-haloisatin thiosemicarbazones and their copper(II) complexes (1-8) were prepared characterized by elemental analysis, NMR, IR, ESI-HRMS, UV-Visible, EPR, TGA powder single crystal X-ray diffraction studies. The possess distorted square planar geometry. study compounds (1-3) confirmed existence in thione tautomeric form. Thein vitro aniproliferative the against cancer cells MCF-7, A431 normal cell PNT2 showed significant antiproliferative activity for...