A5012390301- Advanced NMR Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Advanced MRI Techniques and Applications
- Bone health and osteoporosis research
- Medical Imaging Techniques and Applications
- Inorganic Fluorides and Related Compounds
- Osteoarthritis Treatment and Mechanisms
- Biliary and Gastrointestinal Fistulas
- Electron Spin Resonance Studies
- NMR spectroscopy and applications
- Enzyme Structure and Function
- Molecular Biology Techniques and Applications
- Bone and Dental Protein Studies
- Bone health and treatments
- Synthesis and biological activity
- RNA Research and Splicing
- Solid-state spectroscopy and crystallography
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2020-2024
Centre of Biomedical Research
2020-2024
Integral University
2020-2023
Analysis of the chemical composition gallstones is vital for etiopathogenesis gallstone diseases that can ultimately help in prevention its formation. In present study, from seven different regions India were analyzed to highlight major difference their composition. Also, pathological conditions i.e., benign (chronic cholecystitis, CC) and malignant gallbladder disease (gallbladder cancer GBC) characterized. The type polymorphs cholesterol molecules was also studied provide insight into...
The interactions between glycosaminoglycans (GAGs) and proteins are essential in numerous biochemical processes that involve ion-pair interactions. However, there is no evidence of direct specific GAGs collagen native cartilage. resolution solid-state NMR (ssNMR) can offer such information but the detection GAG cartilage limited by sensitivity experiments when
Solid-state nuclear magnetic resonance is a promising technique to probe bone mineralization and interaction of collagen protein in the native state. However, many developments are hampered due low sensitivity technique. In this article, we report solid-state (NMR) experiments using newly developed BioSolids CryoProbe™ access its applicability for elucidating atomic-level structural details state inside bone. We here approximately fourfold enhancement natural abundance 13 C spectrum compared...
Bone is a living tissue made up of organic proteins, inorganic minerals, and water. The component bone (mainly Type-I collagen) provides flexibility tensile strength. Solid-state nuclear magnetic resonance (ssNMR) one the few techniques that can provide atomic-level structural insights such biomaterials in their native state. In present article, we employed variable contact time cross-polarization (1 H-13 C CP) kinetics experiments to study hydration-dependent changes extracellular matrix...
Bone is a dynamic tissue composed of organic proteins (mainly type I collagen), inorganic components (hydroxyapatite), lipids, and water that undergoes continuous rebuilding process over the lifespan human beings. mineral mainly crystalline apatitic core surrounded by an amorphous surface layer. The supramolecular arrangement different constituents gives rise to its unique mechanical properties, which become altered in various bone-related disease conditions. Many interactions among are...
A series of pyrazole derivatives (2a-m) was synthesized by the reaction pongamol with various hydrazines (1a-m) derivatives. All pyrazoles were screened for their anticancer potential against breast carcinoma (MCF7, MDA-MB-231), ovarian (SKOV3) HeLa cervical cancer cells, and HEK293 MCF10A normal cells. Among 13 compounds, seven compounds PONG, 2j, 2k, 2e, 2m, 2h, 2g found to have more than 50% cell inhibition. Docking study also performed enzyme CYP1A1 using SWISS DOCK.. KEYWORDS :CYP1A1,...