A5101957481- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Birth, Development, and Health
- Respiratory viral infections research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 epidemiological studies
- Blood Pressure and Hypertension Studies
- Occupational and environmental lung diseases
- Nutrition, Genetics, and Disease
- Neurogenetic and Muscular Disorders Research
- Gestational Diabetes Research and Management
- Bone and Dental Protein Studies
- Viral gastroenteritis research and epidemiology
- Diabetes Management and Education
- COVID-19 and Mental Health
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Animal Disease Management and Epidemiology
- Cardiovascular Health and Risk Factors
- Dermatological and COVID-19 studies
- Nutritional Studies and Diet
- Renal cell carcinoma treatment
- Advanced Proteomics Techniques and Applications
TEDA International Cardiovascular Hospital
2020-2024
Suzhou Municipal Hospital
2023-2024
Nanjing University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Tianjin Economic-Technological Development Area
2020-2023
Tianjin University
2023
Chinese People's Armed Police Force
2008-2021
Logistics University of People's Armed Police Force
2012-2021
Tianjin Medical University
2007-2020
Pingjin Hospital
2018
Preeclampsia is a pregnancy‑specific disease characterized by hypertension as well proteinuria after the 20th week of pregnancy. Animal models are effective tools for studying pathogenesis, diagnostic criteria and treatment methods preeclampsia. The present study sought to establish evaluate preeclampsia‑like Sprague Dawley (SD) rat model using N‑nitro‑L‑arginine methyl ester (L‑NAME). Rats were randomly assigned 7 groups (n=10 in each): Control rats treated with low‑dose L‑NAME (40 mg/kg...
Human enterovirus 68 (HEV-68) is an associated with respiratory illness. In China, no information about HEV-68 available for children yet. This study aimed to investigate the presence of in mainland China between 2009 and 2012 explore migration events across world. Among 1565 samples tested from children, 41 (2.6%) were positive HEV 223 (14.3%) human rhinovirus (HRV). Seven (17.1%) HEVs HEV-68. Two HEV-68- five HRV-positive detected 585 adult samples. predominant type acute tract infection...
Background. In early September 2009, an outbreak of influenza occurred at a college campus in Beijing, China, which both pandemic H1N1 and seasonal H3N2 viruses were detected. Methods. Outbreak investigation was performed the campus. Epidemiologic, clinical data collected by interviewing patients retrieving medical records. Individual contact tracing for detailed information. Viruses identified reverse-transcription polymerase chain reaction assays followed sequence analysis. The...
Abstract Background Host genetic factors may play a role in the occurrence and progress of SARS-Cov infection. This study was to investigate relationship between tumor necrosis factor (TNF)- α gene polymorphisms with SARS-CoV infection its prognosis patients lung interstitial fibrosis femoral head osteonecrosis. Methods The association TNF-α susceptibility severe acute respiratory syndromes (SARS) conducted hospital-based case-control including 75 SARS patients, 41 health care workers 92...
Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with high case-fatality rate and devastating socio-economic impact. In this report we summarized the results from an epidemiological investigation of SARS outbreak in hospital Tianjin, between April May 2003. We collected clinical data on 111 suspect probable cases associated outbreak. Transmission chain clusters were investigated. The was single sourced had eight clusters. All traced to patient who directly...
ABSTRACT In December, 2019, an infectious outbreak of unknown cause occurred in Wuhan, which attracted intense attention. Shortly after the virus was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), epidemic disease 2019 (COVID-19) broke out, and information storm occurred. At that time, important aspects, is, stages spread components epidemic, were unclear. Answers to questions (1) what are sources, (2) how do infections occur, (3) who will be affected should...
Abstract Background Lp(a) and LDL-C are both risk factors of atherosclerotic cardiovascular disease (ASCVD). But there was a contradiction point in control. The appropriate level the prevention ASCVD is still pending. Objective To investigate correlation coronary lesion, find out balance Method 3449 patients were divided to heart (CAHD) Group Non-CAHD based on result angiography. clinical characteristics compared, Logistic regressions applied CAHD total, High-LDL-C (LDL-C ≥ 100 mg/dL)...
Background Biomarkers can be used to assess the severity of spinal muscular atrophy (5q SMA; SMA). Despite their potential, relationship between biomarkers and clinical outcomes in SMA remains underexplored. This study aimed association among biomarkers, phenotypes, motor milestones Chinese patients diagnosed with SMA. Methods We collected retrospective follow-up data disease-modifying therapy (DMT)-naïve at our center from 2019 2021. Four were included: survival neuron 2 (SMN2) copies,...
Objective: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis pathogenesis silicosis. Methods: Thirty healthy volunteers, 30 silica-exposed workers, workers with suspected silicosis phase I were included. Serum CC16 SP-D concentrations determined using enzyme-linked immunosorbent assay. Results: decreased when compared controls, but levels increased, this trend was obvious 0+ groups. Discriminant analysis showed that...
Summary Objective To quantify the transmissibility of severe acute respiratory syndrome (SARS) in hospitals mainland China and to assess effectiveness control measures. Methods We report key epidemiological details three major hospital outbreaks SARS China, estimate evolution effective reproduction number each during course outbreaks. Results The successive infected 41, 99 91 people whom 37%, 60% 70% were staff. These cases resulted 33 deaths, five which occurred In a multivariate logistic...
A cohort of 67 confirmed SARS patients were prospectively followed for 16 months and compared with a control population. Serum samples taken at various times tested IgG IgM; dynamic serological changes in these antibodies described. The positive responses IgM sera against virus from the first week to sixth after onset illness measured. ELISA test antibody was negative 200 community controls. rate high-risk population 0.61% by 0.21% IFA. this study defined as those who provided health care...
Background. We followed a cohort of 773 individuals who received monovalent vaccine against 2009 pandemic influenza A (H1N1). Approximately 6 weeks after vaccination, 12 persons developed the disease. Methods. Three groups subjects were studied (12 patients had or not previous and 1 group 49 control previously been immunized with same vaccine). For all patients, clinical features characterized causative viruses sequenced for possible mutations. Nasopharyngeal swabs, serum specimens,...
To develop a predictive model for the oncological outcomes of clear cell renal carcinoma in Chinese population.A retrospective study 1108 patients with who underwent nephrectomy or partial between January 2006 and December 2013 was carried out. Recurrence-free survival calculated using Kaplan-Meier analysis. Differences groups were compared log-rank test. Cox proportional hazard regression used to test associations features outcomes. The discriminative ability models validated Harrell's...
Abstract Objective To determine dynamic changes in clinical characteristics by examining an outbreak of adenovirus infection that occurred from December 20, 2012, to February 25, 2013, Tianjin, China. Methods Active surveillance for febrile respiratory illnesses was conducted, and medical records patients were collected. Real-time quantitative polymerase chain reaction sequencing used pathogen identification viral genome study, respectively. Student’s t -test compare the mean values normally...
Background Preeclampsia (PE) mainly occurs in pregnant women and is hereditary. Several genome-wide association studies (GWAS) on Caucasian samples have reported some gene loci that are associated with preeclampsia. However, these not reached consistent conclusions. No previous GWAS has examined preeclampsia the Chinese Han population.
Stroke is the prime cause of morbidity and mortality in general population, hypertension will increase recurrence stroke. We report a protocol pragmatic randomized controlled trial (RCT) using blood pressure (BP)-lowering acupuncture add-on treatment to treat patients with This large-scale, multicenter, subject-, assessor- analyst-blinded, RCT. A total 480 ischemic stroke be randomly assigned two groups: an experimental group control group. The receive "HuoXueSanFeng" combined one...
Abstract Early warning of hypertensive disorder in pregnancy (HDP) can improve maternal and infant outcomes. However, few studies had evaluated the value high–normal blood pressure (BP) before onset HDP. This was a prospective cohort study to investigate relationship between high‐normal BP first half risk According maximum measured 20 +6 weeks gestation, divided into three groups: optimal (SBP < 120 mmHg DBP 80 mmHg), normal (120 ≤ SBP 130 or 85 (130 140 90 mmHg). The different levels HDP...
Objective: To screen for serum biomarkers of silicosis and to study their roles using surface-enhanced laser desorption ionization time-of-fly mass spectrometry (SELDI-TOF-MS) techniques. Methods: The protein/peptide profile on the CM10 proteinchip was acquired SELDI-TOF-MS from workers classified by Chinese national diagnostic standard pneumoconiosis. Discriminant analysis performed establish a decision tree peaks. Results: Protein/peptide peaks changed much more in silica-exposed...