A5087456098- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Spinal Cord Injury Research
- 3D Printing in Biomedical Research
- Wound Healing and Treatments
- Sulfur Compounds in Biology
- Peptidase Inhibition and Analysis
- Bone Tissue Engineering Materials
- Full-Duplex Wireless Communications
- Antenna Design and Optimization
- Cellular Mechanics and Interactions
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Reconstructive Surgery and Microvascular Techniques
- Satellite Communication Systems
- Redox biology and oxidative stress
- Electromagnetic Fields and Biological Effects
- Transcranial Magnetic Stimulation Studies
- Silk-based biomaterials and applications
- Neurogenesis and neuroplasticity mechanisms
Tsinghua University
2012-2025
State Key Laboratory of New Ceramics and Fine Processing
2021-2024
National Taiwan University
2013
Institute of Biological Chemistry, Academia Sinica
2013
3D bioprinting holds great promise toward fabricating biomimetic living constructs in a bottom-up assembly manner. To date, various emergences of have been bioprinted for
Abstract The effective and safe healing of chronic wounds, such as diabetic ulcers, presents a significant clinical challenge due to the adverse microenvironment in wound that hinders essential processes healing, including angiogenesis, inflammation resolution, bacterial control. Therefore, there is an urgent demand for development cost-effective multifunctional therapeutic dressings. Silicon nitride, with its distinctive antibacterial properties bioactivities, shows great potential...
Distinctive states of redox-dependent cysteine (Cys) modifications are known to regulate signaling homeostasis under various pathophysiological conditions, including myocardial injury or protection in response ischemic stress. Recent evidence further implicates a dynamic interplay among these modified forms following changes cellular redox environment. However, precise delineation multiplexed Cys context remains technically challenging. To this end, we have now developed mass spectrometry...
Abstract The inhospitable niche at the injury site after spinal cord (SCI) brings several challenges to neural stem cell (NSC) therapy, such as limited NSC retention and neuronal differentiation. Biomaterial-based transplantation has become a promising strategy for building favorable cells. Herein, an aligned fibrin nanofiber hydrogel modified with N-Cadherin-Fc (AFGN) was fabricated by electrospinning biochemical conjugation deliver NSCs SCI repair. AFGN provides multimodal cues, including...
Nerve guidance conduits (NGCs) have been widely accepted as a promising strategy for peripheral nerve regeneration. Fabricating ideal NGCs with good biocompatibility, biodegradability, permeability, appropriate mechanical properties (space maintenance, suturing performance, etc.), and oriented topographic cues is still current research focus. From the perspective of translation, technique stability scalability are also an important consideration industrial production. Recently, blow-spinning...
Abstract Magnetic stimulation is becoming an attractive approach to promote neuroprotection, neurogenesis, axonal regeneration, and functional recovery in both the central nervous system peripheral disorders owing its painless, non-invasive, deep penetration characteristics. Here, a magnetic-responsive aligned fibrin hydrogel (MAFG) was developed import amplify extrinsic magnetic field (MF) locally stimulate spinal cord regeneration combination with beneficial topographical biochemical cues...
Utilizing biomaterials in tissue engineering has shown considerable promise for regeneration, particularly through delivering a range of cell-regulatory signals, both inherent to the material and external. In this research, we developed magnetic-responsive aligned nanofiber fibrin hydrogel (MAFG), integrating structured alignment nanofibers pliability with an external magnetic field. This design aimed enhance regenerative response spinal cord injury treatment. A medium-strength field, cord,...
Fibrous biotextiles are very popular structural forms that widely used in medical products and devices ranging from sutures, bandages, wound dressing, patches to all kinds of artificial grafts such as ligaments, tendons, blood vessels, heart valves, tissue engineered scaffolds. Blow-spinning is a recently developed technique enables the large-scale efficient production ultrathin fibers with diameters micrometer nanometer. In this study, blow-spinning process parameters were optimized...
Neural stem cells (NSCs) represent significant potential and promise in the treatment of neurodegenerative diseases nerve injuries. An efficient methodology or platform that can help specifically directing cell fate is important highly desirable for future clinical therapy. In this study, a biodegradable electrical conductive film composed an oxidative polymerized carboxyl-capped aniline pentamer (CCAP) ring-opening tetra poly(d,l-lactide) (4a-PLA) was designed with addition dopant, namely...
Nerve guidance conduits (NGCs) have been widely accepted as a promising strategy for peripheral nerve regeneration. Fabricating ideal NGCs with good biocompatibility, biodegradability, permeability, appropriate mechanical properties (space maintenance, suturing performance, etc.), and oriented topographic cues is still current research focus. From the perspective of translation, technique stability scalability are also an important consideration industrial production. Recently, blow-spinning...
Using dually-polarized technology to double the spectral efficiency is very attractive in satellite communication systems. However, cross polarization interference (XPI) which inevitable will degrade performance of system. In order eliminate it, a cancellation (XPIC) necessary, at least under unfavourable propagation conditions. This paper mainly studies issue for radio systems over earth-space links. A joint XPIC and DEAF presented, compared with conventional XPIC, other equalizer...
Magnetic stimulation is becoming an attractive approach to promote neuroprotection, neurogenesis, axonal regeneration, and functional recovery in both the central nervous system (CNS) peripheral (PNS) disorders owing its painless, non-invasive, deep penetration characteristics. Here, a magnetic-responsive aligned fibrin hydrogel (MAFG) was developed import amplify extrinsic magnetic field (MF) locally stimulate spinal cord regeneration combination with beneficial topographical biochemical...