A5050347971- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Breast Cancer Treatment Studies
- Nanoparticle-Based Drug Delivery
- Antiplatelet Therapy and Cardiovascular Diseases
- Crystallization and Solubility Studies
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Sensor and Energy Harvesting Materials
- X-ray Diffraction in Crystallography
- Radiation Therapy and Dosimetry
- Advanced Photocatalysis Techniques
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- RNA Interference and Gene Delivery
- Retinal Diseases and Treatments
- Immunotherapy and Immune Responses
- Medication Adherence and Compliance
- Cancer Risks and Factors
- Cancer, Hypoxia, and Metabolism
- Acute Myocardial Infarction Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- HER2/EGFR in Cancer Research
- Medical and Biological Ozone Research
- Migraine and Headache Studies
- Head and Neck Cancer Studies
Tsinghua University
2019-2024
Shanghai Jiao Tong University
2023-2024
Renji Hospital
2015-2024
Gannan Medical University
2024
State Key Laboratory of New Ceramics and Fine Processing
2019-2024
IQVIA (United States)
2013-2023
Zhejiang University of Technology
2019-2023
Institute of Process Engineering
2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2018-2021
Beijing University of Chinese Medicine
2021
Regarded as one of the hallmarks tumorigenesis and tumor progression, evasion apoptotic cell death would also account for treatment resistance or failure during cancer therapy. In this study, a Ca2+/Cu2+ dual-ion "nano trap" to effectively avoid apoptosis by synchronously inducing paraptosis together with was successfully designed fabricated breast treatment. brief, disulfiram (DSF)-loaded amorphous calcium carbonate nanoparticles (NPs) were via gas diffusion method. Further on, Cu2+-tannic...
Abstract Transformable liquid metal (LM)‐based materials have attracted considerable research interest in biomedicine. However, the potential biomedical applications of LMs not yet been fully explored. Herein, for first trial, inductive heating property gallium–indium eutectic alloy (EGaIn) under alterative magnetic field is systematically investigated. By virtue its inherent metallic nature, LM possesses excellent as compared to conventional magnetite nanoparticles, therefore enabling...
With tremendous research advances in biomedical application, liquid metals (LM) also offer fantastic chemistry for synthesis of novel nano-composites. Herein, as a pioneering trial, litchi-shaped heterogeneous eutectic gallium indium-Au nanoparticles (EGaIn-Au NPs), served effective radiosensitizer and photothermal agent radio-photothermal cancer therapy, have been successfully prepared using situ interfacial galvanic replacement reaction. The enhanced conversion efficiency boosted...
The therapeutic efficacy of bone tumor treatment is primarily limited by inadequate resection, resulting in recurrence and metastasis, as well the deep location tumors. Herein, an injectable doxorubicin (DOX)-loaded magnetic alginate hydrogel (DOX@MAH) was developed to evaluate alternating field (AMF)-responsive, chemothermal synergistic therapy for multimodality prepared exhibits a superior drug-loading capacity continuous DOX release. This multifunctionality can be attributed combined use...
Breast carcinoma and precancer are thought to start in the lining of milk duct or lobule, yet until recently, we have not had direct access this area other than by blindly removing tissue core biopsy fine-needle aspiration. Fiberoptic ductoscopy (FDS) is an emerging technique allowing visual ductal system breast through nipple orifice exploration.We applied 259 women who discharge, analyzed findings, cytological washings, subsequent histopathology.In 92 (36%) these women, fiberoptic was...
Objectives The 30‐day clinical outcomes with prasugrel or ticagrelor were compared using a US payer database in patients acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI). Background Prasugrel and demonstrated superior efficacy increased non‐coronary artery bypass graft major bleeding clopidogrel randomized trials. No direct observational studies have between ticagrelor. Methods Patients hospitalized for ACS‐PCI August 1, 2011 April 30, 2013 prescribed selected. Drug...
Purpose: Intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents including ranibizumab and aflibercept are used to treat patients with ocular disorders such as neovascular age-related macular degeneration (nAMD); however, the associated rare instances severe inflammation. This study compared inflammation rates in treated versus aflibercept. Methods: United States physician-level claims data covering an 18-month period for each therapy were analyzed. The primary...
Purpose To compare treatment patterns of intravitreal ranibizumab and aflibercept for the management neovascular age-related macular degeneration (nAMD) in a real-world setting over first 12 months treatment. Methods A proprietary clinical database was used to identify treatment-naïve patients with nAMD USA claims or between November 1, 2011 30, 2013 follow-up at least months. Patients were considered if they had no anti-VEGF code 6 before index date. Mean numbers injections non-injection...
Abstract Chemodynamic therapy (CDT) is a novel therapeutic modality that employs Fenton or Fenton‐like reaction to destroy cancer cells via the disproportionation of intratumoral hydrogen peroxide (H 2 O ) highly toxic hydroxyl radical (·OH) without external energy input. A efficient chemodynamic catalyst in tumor microenvironment (TME) key effective anti‐tumor efficacy. Therefore, ultra‐sensitive FePd‐TPP/adriamycin (ADM) nanocrystals (NCs) are constructed simple thermal decomposition...
Cell necroptosis has presented great potential, acting as an effective approach against tumor apoptotic resistance, and it could be further enhanced via accompanying reactive oxygen species (ROS) overexpression. However, whether overproduced ROS assists the necroptotic pathway remains unclear. Thus, iron-palladium nanozyme (FePd NZ)- shikonin (SKN)-encapsulated functional lipid nanoparticles (FPS-LNPs) were designed to investigate overexpression-enhanced SKN-induced necroptosis. In this...
The genetic etiology of hereditary breast cancer has not been fully elucidated. Although germline mutations high-penetrance genes such as BRCA1/2 are implicated in development cancers, at least half all families linked to these genes. To identify a comprehensive spectrum factors for Chinese population, we performed an analysis 2,165 coding exons 152 associated with using next-generation sequencing (NGS) 99 patients from regardless types. Forty-two deleterious were identified 21 34 patients,...
Abstract Magnetic stimulation is becoming an attractive approach to promote neuroprotection, neurogenesis, axonal regeneration, and functional recovery in both the central nervous system peripheral disorders owing its painless, non-invasive, deep penetration characteristics. Here, a magnetic-responsive aligned fibrin hydrogel (MAFG) was developed import amplify extrinsic magnetic field (MF) locally stimulate spinal cord regeneration combination with beneficial topographical biochemical cues...
With the inspiration to develop new cancer nanotherapeutics by repurposing old drugs, in current study, we proposed dihydroartemisinin loaded layered double hydroxide with peroxide self-supplying property for enhanced photothermal–chemodynamic therapy.
Fe-Doped Mg–Al layer double hydroxide NPs were endowed with enhanced photo-induced ability and T 2 -weighted MR effect for cancer theranostic application.
Utilizing biomaterials in tissue engineering has shown considerable promise for regeneration, particularly through delivering a range of cell-regulatory signals, both inherent to the material and external. In this research, we developed magnetic-responsive aligned nanofiber fibrin hydrogel (MAFG), integrating structured alignment nanofibers pliability with an external magnetic field. This design aimed enhance regenerative response spinal cord injury treatment. A medium-strength field, cord,...
Immunotherapy has established a new paradigm for cancer treatment and made many breakthroughs in clinical practice. However, the rarity of immune response suggests that additional intervention is necessary. In recent years, it been reported local tumor destruction (LTD) can cause cell death induce an immunologic response. Thus, combination immunotherapy LTD methods will be promising approach to improve efficiency treatment. Herein, nanobiotechnology platform achieve high-precision systemic...
Abstract Nanoheterostructures with exquisite interface and heterostructure design find numerous applications in catalysis, plasmonics, electronics, biomedicine. In the current study, series core–shell metal or oxide‐based heterogeneous nanocomposite have been successfully fabricated by employing sandwiched liquid (LM) layer (i.e., LM oxide/LM/LM oxide) as interfacial galvanic replacement reaction environment. A self‐limiting thin oxide layer, which would naturally occur at metal–air under...