A5102799065- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Characterization and Applications of Magnetic Nanoparticles
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Photoacoustic and Ultrasonic Imaging
- Immune cells in cancer
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- TGF-β signaling in diseases
- Inflammation biomarkers and pathways
- Molecular Sensors and Ion Detection
- Induction Heating and Inverter Technology
- Nanoparticles: synthesis and applications
- Photoreceptor and optogenetics research
- Organic Light-Emitting Diodes Research
- Nanocluster Synthesis and Applications
- Iron oxide chemistry and applications
Hebei University of Technology
2023-2024
Northwest University
2018-2023
Ministry of Education of the People's Republic of China
2019-2023
Chinese Academy of Sciences
2016-2020
National Center for Nanoscience and Technology
2015-2020
Tianjin University
2014-2018
Center for NanoScience
2015-2016
University of Chinese Academy of Sciences
2016
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015
Many theranostic nanomedicines (NMs) have been fabricated by packaging imaging and therapeutic moieties together. However, concerns about their potential architecture instability pharmacokinetic complexity remain major obstacles to clinical translation. Herein, we demonstrated the use of CuInS/ZnS quantum dots (ZCIS QDs) as "all-in-one" that possess intrinsic capabilities within a well-defined nanostructure. ZCIS QDs were exploited for multispectral optical tomography (MSOT) synergistic...
Cancer metastasis is a serious concern and major reason for treatment failure. Herein, we have reported the development of an effective safe nanotherapeutic strategy that can eradicate primary tumors, inhibit metastasizing to lung, control growth distant tumors. Briefly, ferrimagnetic vortex-domain iron oxide nanoring (FVIO)-mediated mild magnetic hyperthermia caused calreticulin (CRT) expression on 4T1 breast cancer cells. The CRT transmitted "eat-me" signal promoted phagocytic uptake cells...
In this study, a magnetothermodynamic (MTD) therapy is introduced as an efficient systemic cancer treatment, by combining the magnetothermal effect and reactive oxygen species (ROS)-related immunologic effect, in order to overcome obstacle of limited therapeutic efficacy current (MTT). This approach was achieved development elaborate ferrimagnetic vortex-domain iron oxide nanoring graphene (FVIOs-GO) hybrid nanoparticle MTD agent. Such FVIOs-GO nanoplatform shown have high thermal conversion...
Understanding metabolism and dynamic biological events in cells, as well physiological functions pathological changes organisms, is the major goal of investigations. It will improve our capability to diagnose treat diseases, enhance personalized medicine. Fluorescence imaging a powerful tool that plays an essential role acquiring comprehensive knowledge necessary help reach this goal. Fluorescent molecules are crucial factors for obtaining high quality images. In contrast conventional...
Efficient small interfering RNA (siRNA) delivery in the presence of serum is crucial importance for effective gene therapy. Fluorinated vectors are considered to be attractive candidates siRNA-mediated therapy because their efficacy serum-containing media. However, mechanisms driving superior transfection behavior fluorinated still not well-understood, and comprehensive investigations warranted. Herein, we fabricated a library perfluorooctanoyl fluoride-fluorinated (PFF-fluorinated)...
It remains an unresolved challenge to achieve spatial and temporal monitoring of drug release from nanomedicines (NMs) in vivo, which is crucial importance disease treatment. To tackle this issue, we constructed core-satellite ICG/DOX@Gel-CuS NMs, consist gelatin (Gel) nanoparticles (NPs) with payloads near-infrared fluorochrome indocyanine green (ICG) chemo-drug doxorubicin (DOX) surrounding CuS NPs. The fluorescence ICG was initially shielded by satellite NPs within the intact NMs...
Owing to their unique physicochemical properties and comparable size biomacromolecules, functional nanostructures have served as powerful supports construct enzyme-nanostructure biocatalysts (nanobiocatalysts). Of particular importance, recent years witnessed the development of novel nanobiocatalysts with remarkably increased enzyme activities. This review provides a comprehensive description advances in field nanobiocatalysts, systematic elaboration underlying mechanisms activity...
The microtechnology of controlling stimuli-responsive biomaterials at micrometer scale is crucial for biomedical applications. Here, we report bovine serum albumin (BSA)-based three-dimensional (3D) microstructures with tunable surface morphology and pH-responsive properties via two-photon polymerization microfabrication technology. laser processing parameters, including power, scanning speed, layer distance, are optimized the fabrication well-defined 3D BSA microstructures. a wide range pH...
The development of a clinical chemotherapeutic is not an easy task. One challenge how to deliver the agent cancer cells. Nano-formulation prodrugs, which combines strengths nanotechnology and possesses many advantages for drug delivery, including high loading efficiency, improved availability enhanced accumulation in Here, we have constructed small library Irinotecan-derived 20-hydroxyl group was derived with fatty-acid moieties through esterification. This conjugation fine-tuned polarity...
High-efficiency gene transfer and suitably low cytotoxicity are the main goals of transfection systems based on nonviral vectors. In addition, it is desirable to track process in order observe explain mechanism. Herein, inspired by viral structures that optimized for delivery, we designed a small-molecule vector (TR4) with aggregation-induced emission properties capping peptide containing four arginine residues tetraphenylethene (TPE) lipophilic tail. This novel can self-assemble plasmid DNA...
Abstract Magnetic nanomaterials have been widely used in various biomedical applications, which seen accelerating interest since the breakthrough chemical synthesis of monodispersed iron oxide nanoparticles. nanoparticles (MIONs) possess excellent biocompatibility, and they can produce multiple physicochemical effects when exposed to magnetic fields. Due this rapid development MIONs for cancer diagnosis therapy, it becomes necessary present a comprehensive review paper from engineering...
Sepsis is defined as a life-threatening organ dysfunction caused by excessive formation of reactive oxygen species (ROS) and dysregulated inflammatory response. Previous studies have reported that shikonin (Shik) possess prominent anti-inflammatory antioxidant effects holds promise potential therapeutic drug for sepsis. However, the poor water solubility relatively high toxicity hamper its clinical application. To address this challenge, we constructed Zn2+-shikonin nanoparticles, hereafter...
Magnetothermodynamic (MTD) therapy can activate antitumor immune responses by inducing potent immunogenic tumor cell death. However, development is often accompanied multifarious immunosuppressive mechanisms that counter the efficacy of MTD therapy. High-mobility group protein A1 (HMGA1) overexpressed within hepatocellular carcinoma tissues and plays a crucial function in generation effects. The reversal HMGA1-mediated immunosuppression could enhance death-induced responses. A ferrimagnetic...
A new type of magnetic vortex-domain nanoparticles, EMPs, was prepared, which showed great heating capability and enabled efficient inhibition tumor growth.
The low transfection efficiency of polycations is still a major problem for successful gene therapy. To address this issue, in study, hydrophilic poly(vinyl pyrrolidone)-graft-poly[2-(N,N-dimethylamino)ethyl methacrylate] (PVP-g-PDMAEMA) and amphiphilic methacrylate]-block-poly(methylmethacrylate) (PVP-g-PDMAEMA-b-PMMA) were synthesized via the atom transfer radical polymerization (ATRP) method, their properties as vectors investigated subsequently. PVP-g-PDMAEMA formed random coils water...