A5081996243- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Photodynamic Therapy Research Studies
- Dendrimers and Hyperbranched Polymers
- Photoacoustic and Ultrasonic Imaging
- Carbon and Quantum Dots Applications
- Barrier Structure and Function Studies
- nanoparticles nucleation surface interactions
- Sulfur Compounds in Biology
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Metal complexes synthesis and properties
- Nanocluster Synthesis and Applications
- Hepatitis C virus research
- Ocular Disorders and Treatments
- Characterization and Applications of Magnetic Nanoparticles
- Curcumin's Biomedical Applications
- Diet and metabolism studies
Hebei University
2013-2025
China Resources (China)
2018-2023
National Center for Nanoscience and Technology
2016-2021
Chinese Academy of Sciences
2017-2021
University of Chinese Academy of Sciences
2017-2018
Ministry of Education of the People's Republic of China
2015-2017
Baoding University
2015-2017
Central South University
1998
Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H
Many theranostic nanomedicines (NMs) have been fabricated by packaging imaging and therapeutic moieties together. However, concerns about their potential architecture instability pharmacokinetic complexity remain major obstacles to clinical translation. Herein, we demonstrated the use of CuInS/ZnS quantum dots (ZCIS QDs) as "all-in-one" that possess intrinsic capabilities within a well-defined nanostructure. ZCIS QDs were exploited for multispectral optical tomography (MSOT) synergistic...
Potential bioaccumulation is one of the biggest limitations for silica nanodrug delivery systems in cancer therapy. In this study, a mesoporous nanoparticles/hydroxyapatite (MSNs/HAP) hybrid drug carrier, which enhanced biodegradability silica, was developed by one-step method. The morphology and structure nanoparticles were characterized TEM, DLS, FT-IR, XRD, N2 adsorption-desorption isotherms, XPS, loading release behaviors tested. TEM ICP-OES results indicate that degradability has been...
In this study, a magnetothermodynamic (MTD) therapy is introduced as an efficient systemic cancer treatment, by combining the magnetothermal effect and reactive oxygen species (ROS)-related immunologic effect, in order to overcome obstacle of limited therapeutic efficacy current (MTT). This approach was achieved development elaborate ferrimagnetic vortex-domain iron oxide nanoring graphene (FVIOs-GO) hybrid nanoparticle MTD agent. Such FVIOs-GO nanoplatform shown have high thermal conversion...
Multidrug resistance (MDR) is the key cause that accounts for failure of clinical cancer chemotherapy. To address problem, herein, we presented an alternative strategy to conquer drug-resistant breast through combinatorial delivery Ca2+ channel siRNA with cytotoxic drugs. Mesoporous silica nanocapsules (MSNCs) mesoporous and hollow structure were fabricated co-delivery T-type doxorubicin (DOX) high drug loading efficiency. The DOX/siRNA co-loaded MSNCs showed a synergistic therapeutic effect...
An ideal radiosensitizer holding an enhanced tumor retention can play incredible role in enhancing radiotherapy. Herein, a strategy of acid-triggered aggregation small-sized gold nanoparticles (GNPs) system within is proposed and the resulting GNPs aggregates are applied as vitro vivo. The with achieves accumulation cancer cells tumors form resulted aggregates. As consequence, radiosensitization effect shows significant improvement radiotherapy, which shown studies DNA breakage comet assay,...
DNA alkylating agents generally kill tumor cells by covalently binding with to form interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few adducts (<1%) are highly toxic irreparable Furthermore, cisplatin is rapidly detoxified high levels intracellular thiols such as glutathione (GSH). Since discovery its mechanism action, people have been looking for ways directly and efficiently remove GSH increase cross-links improve drug efficacy overcome resistance, but...
Abstract Immunological adjuvants are essential for successful cancer vaccination. However, traditional have some limitations, such as lack of controllability and induction systemic toxicity, which restrict their broad application. Here, we present a light-activable immunological adjuvant (LIA), is composed hypoxia-responsive amphiphilic dendrimer nanoparticle loaded with chlorin e6. Under irradiation near-infrared light, the LIA not only induces tumour cell lysis antigen release, but also...
Safety and efficiency remain the critical hurdles hindering practical application of gene agents, even though great effort has been made to develop various carriers. Herein, we present a novel biodegradable cancer therapeutic system based on DNA nanoflowers (DNFs) for targeted dual silencing. The was constructed by copying rolling circle amplification template produce long single-stranded DNAs with cell targeting gene-silencing capability. structure DNFs collapsed at acidic pH due...
Abstract Ocular inflammations are common diseases that may lead to serious vision‐threatening obstacles. Eye drops for antiinflammation therapy need be administered multiple times daily at a high dosage due the rapid precorneal removal and low bioavailability of drugs. To overcome these problems, cRGD‐functionalized DSPE‐PEG 2000 nanomicelle (DSPE‐PEG ‐cRGD) encapsulated with flurbiprofen is proposed. The tailored nanomicelles trigger specific binding integrin receptors on ocular surface,...
Vitamin E derivatives possess many essential features for drug-delivery applications, such as biocompatibility, stability, improvement of water solubility hydrophobic compounds, anticancer activity, and the ability to overcome multidrug resistance (MDR). Herein, vitamin are used MDR through a combined P-glycoprotein (P-gp) inhibition mitochondrial impairment strategy. A novel nanomicellar system carrier doxorubicin (DOX) was developed, in which d-α-tocopheryl polyethylene glycol 1000...
Nanomaterials have unique physicochemical properties, such as large surface area to mass ratio, ultra small size and high reactivity, which are different from bulk materials with the same composition. These properties can be used overcome some limitations found in traditional therapeutic diagnostic agents. The application of nanomaterials medicine pharmaceuticals is increasing rapidly offers excellent prospects. In this review, we will provided an overview on nanomaterial developments less...
Hydroxyapatite nanoparticles (HAPs) cause apoptosis of osteoblastic MC3T3-E1 cells through oxidative stress-induced lysosomal and mitochondrial pathway.
Flurbiprofen, a hydrophobic COX inhibitor, was coordinated axially with oxoplatin to form new conjugate, cis,cis,trans-[Pt(IV)(NH3)2Cl2(flurbiprofen)2]. The successful synthesis of this conjugate confirmed by 1H, 13C, and 195Pt NMR. potential being reduced cisplatin subsequently exerting its DNA cross-linking ability verified using cyclic voltammetry (CV), HPLC, mass spectrometry (MS). This showed markedly higher cytotoxicity on many cancer cell lines than cisplatin, flurbiprofen, their...