Irisin is a recently discovered myokine, involved in the browning of white adipose tissue. To date, its function has been mainly associated with energy homeostasis and metabolism, it proposed as promising therapeutic target for obesity metabolic diseases. This first study investigating role irisin human breast cancer. Participants included one hundred (101) female patients invasive ductal cancer fifty (51) healthy women. Serum levels irisin, leptin, adiponectin resistin were quantified...

To study the effect of repeated retinal thickness fluctuations during anti-VEGF therapy maintenance phase in neovascular age-related macular degeneration (nAMD).Data were extracted from electronic medical records 381 nAMD patients, aged ≥50 years; baseline VA ≥33 and ≤73 letters; ≥24 months' follow-up ≥2 optical coherence tomography (OCT) measurements. OCT scans analysed using an artificial intelligence algorithm that quantified volumes intraretinal fluid (IRF), subretinal (SRF), pigment...

Characterize real-world baseline visual acuity (VA) and anti-vascular endothelial growth factor (VEGF) treatment patterns in neovascular age-related macular degeneration patients 2012-2015.Retrospective, multicenter, noninterventional evidence study.A total of 98 821 eyes from 79 885 receiving intravitreal anti-VEGF therapy.Anonymized patient data routinely collected over 5 years were extracted 58 United States centers to a central database using an electronic medical records system.Baseline...

Purpose To compare treatment patterns of intravitreal ranibizumab and aflibercept for the management neovascular age-related macular degeneration (nAMD) in a real-world setting over first 12 months treatment. Methods A proprietary clinical database was used to identify treatment-naïve patients with nAMD USA claims or between November 1, 2011 30, 2013 follow-up at least months. Patients were considered if they had no anti-VEGF code 6 before index date. Mean numbers injections non-injection...

Abstract Background/objectives To investigate the association between optical coherence tomography (OCT) markers of lesion activity and changes in visual acuity (VA) during anti-vascular endothelial growth factor (anti-VEGF) therapy eyes diagnosed with neovascular age-related macular degeneration (nAMD); how VA OCT are considered physicians’ decision to retreat anti-VEGFs. Subjects/methods Retrospective, non-comparative, non-randomised cohort study involving electronic medical record data...

Anti-vascular endothelial growth factors (anti-VEGFs) are considered standard of care therapy for diabetic macular oedema (DME). This study examined treatment patterns and outcomes in patients with DME treated anti-VEGF therapy.Using anonymized electronic medical record data collected from three UK sites, this retrospective cohort assessed rates intravitreal injections adults treatment-naïve who received their first between 1 September 2010 31 July 2018. The proportion at least one interval...

Purpose A recently developed ranibizumab prefilled syringe (PFS) eliminates several preparatory steps versus the standard vial-based method, and is expected to reduce preparation time (SPT) enhance procedural simplicity for intravitreal injections. Methods Syringe times PFS vial were recorded during treatment sessions at 2 centers, without randomization. The duration of each step in preparing was recorded. At center, total SPT (mean all steps) method compared using a 2-tailed t test. Results...

Examine the efficacy of a competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate glutamate receptor antagonist, selurampanel (BGG492), in human photostimulation model.Patients with epilepsy and generalized epileptiform electroencephalography response to intermittent photic stimulation (photoparoxysmal or PPR; diagnosed ≥ 6 months prior initial study dosing) were enrolled phase II, multicenter, single-blind, within-subject, placebo-controlled proof-of-concept (PoC)...

Treat and extend (T&E) is a standard treatment regimen for treating neovascular age-related macular degeneration (nAMD) with anti-vascular endothelial growth factors (anti-VEGFs), but the intervals attained are not well documented. This retrospective, non-comparative, non-randomised study of eyes nAMD classified interval sequences in T&E cohort Australia using Electronic Medical Records (EMR) data. We analysed data from 632 treatment-naïve 555 patients injected ranibizumab, aflibercept or...

Abstract Background Social media platforms are increasingly being used by stakeholders to generate, access, and share health-related information experiences. Lung cancer is the most common cancer, impacting > 2 million patients globally. This observational study utilized a social listening approach analyze trends gain insights into stakeholder perceptions of lung cancer. Methods retrospectively collated data from open access blogs, forums, networking sites. posts were collected between...

Cutaneous melanoma is an aggressive malignancy that proposed to account for 90% of skin cancer-related mortality. Individuals with experience both physical and psychological impacts associated their diagnosis treatment. Health-related information being increasingly accessed shared by stakeholders on social media platforms.This study aimed assess how individuals living across 14 European countries use discuss needs provide perceptions the disease.Social sources including Twitter, forums,...

Deregulation of the endothelin system, comprised endothelin-1 (ET-1), its isoforms (ET-2 and ET-3) their receptors (ETAR ETBR), is under investigation in various types human cancer. ET-1 has been suggested to participate breast cancer development progression, while Big ET-1, biological precursor, also found elevated patients. In present study, we investigated plasma levels patients with suspicious mammographic lesions, order assess potential application as diagnostic biomarkers early...

The effectiveness of intravitreal anti-vascular endothelial growth factor agents is usually lower in real world settings compared with randomized clinical trials (RCTs), often limiting the use real-world evidence (RWE) regulatory and healthcare decisions. current analysis aimed to develop validate an algorithm explain difference outcomes between RWE studies RCTs patients neovascular age-related macular degeneration.The was developed using ranibizumab data (RWD) from US validated on...

To assess the long-term comparative effectiveness of ranibizumab versus switching to aflibercept in neovascular age-related macular degeneration (nAMD).A 24-month, retrospective, comparative, nonrandomized, matched cohort study.Patients with nAMD initiated on who remained (nonswitchers) or switched (switchers) captured from a United States electronic medical records database between July 1, 2011 and October 12, 2014.Patient eyes were for baseline age, visual acuity (VA), VA at month 3,...

Graft-versus-host disease (GVHD) is the major cause of short- and long-term morbidity mortality after allogeneic hematopoietic stem cell transplantation. Treatment options beyond corticosteroid therapy remain limited, prolonged treatment often leads to impaired quality life (QoL). A better understanding needs experiences patients with GVHD required improve patient care.The aim this study explore different social media (SM) channels for gathering analyzing other stakeholders across 14...