A5102996310- Nanoplatforms for cancer theranostics
- Layered Double Hydroxides Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Photocatalysis Techniques
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Inorganic Chemistry and Materials
- Micro and Nano Robotics
- Magnesium Oxide Properties and Applications
- Supercapacitor Materials and Fabrication
- Metal-Organic Frameworks: Synthesis and Applications
- Carbon and Quantum Dots Applications
- Legionella and Acanthamoeba research
- MXene and MAX Phase Materials
- Polyoxometalates: Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanocluster Synthesis and Applications
- Conducting polymers and applications
- Luminescence Properties of Advanced Materials
- Polymer Surface Interaction Studies
- Advanced Sensor and Energy Harvesting Materials
- DNA and Nucleic Acid Chemistry
- Photodynamic Therapy Research Studies
UNSW Sydney
2016-2025
ARC Centre of Excellence in Advanced Molecular Imaging
2025
Xiangyang Central Hospital
2022-2024
The University of Queensland
2007-2017
Brisbane School of Theology
2014-2016
Hanyang University
2016
Tianjin Municipal Research Institute for Family Planning
2005
Tsinghua University
2005
Recently, Mn(II)-containing nanoparticles have been explored widely as an attractive alternative to Gd(III)-based T1 -weighted magnetic resonance imaging (MRI) contrast agents (CAs) for cancer diagnosis. However, far it is known, no Mn-based MRI CAs reported sensitively respond a very weakly acidic environment (pH 6.5-7.0, i.e., the pH range in tumor microenvironment) with satisfactory performance. Here, recently devised pH-ultrasensitive layered double hydroxide (Mn-LDH) superb longitudinal...
This review summarizes and discusses the very recent developments paradigms of ultrathin B.P. nanosheets in versatile biomedical applications.
Abstract DNA nanostructures have been demonstrated as promising carriers for gene delivery. In the carrier design, spatiotemporally programmable assembly of under nanoconfinement is important but has proven highly challenging due to complexity–scalability–error DNA. Herein, a nanotechnology-based strategy via cascade hybridization chain reaction (HCR) hairpins in polymeric nanoframework developed achieve precise siRNA The prepared precipitation polymerization with Acrydite-DNA cross-linker....
MicroRNA (miRNA) represents a promising class of therapeutic nucleic acid drugs, while delivery challenges remain that impede the advancement miRNA therapy, largely because in vivo instability and low efficiency. Herein, we discover dual roles metal–organic framework (MOF) nanoparticles (ZIF-8) as nanocarriers for adjuvants chemodynamic therapy. The miR-34a-m@ZIF-8 complex demonstrated efficient cellular uptake lysosomal stimuli-responsive release. Zn2+ triggered generation reactive oxygen...
Magnesium-aluminum-chloride-layered double hydroxides (MgAl-Cl-LDHs) intercalated with low molecular weight heparin (LMWH) were prepared for the first time by coprecipitation method and then characterized XRD, elemental analysis, FTIR, SEM, TEM. MgAl-LDH was studied as drug carrier LMWH, a widely used anticoagulant, in order to overcome some of its pharmaceutical limitations, such short half-life. In vitro release tests LMWH-LDH pH 7.4 PBS at 37 °C show biphasic sustained profile LMWH anion...
Soft organisms such as earthworms can access confined, narrow spaces, inspiring scientists to fabricate soft robots for in vivo manipulation of cells or tissues and minimally invasive surgery. We report a super-soft super-elastic magnetic DNA hydrogel-based robot (DNA robot), which presents shape-adaptive property enables magnetically driven navigational locomotion confined unstructured space. The hydrogel is designed with combinational dynamic permanent crosslinking network through chain...
Abstract 2D nanomaterials represent one of the next‐generation biomaterials with versatile physicochemical advantages that allow for diverse biomedical applications in disease diagnosis, prevention, and treatment. In particular, layered double hydroxide (LDH) nanoparticles, as a typical nanomaterial, have recently shown unprecedented advances controllable simplified chemical construction, surface engineering, comprehensive biological investigation. To realize vivo applications, recent...
We introduced a new strategy of albumin pre-coating to effectively stabilise layered double hydroxide (LDH) nanoparticles for biomedical applications.
Abstract Immunogenic cancer cell death (ICD) is drawing worldwide attention as it allows dying cells to regulate the host's anti‐tumor immune system and awaken immunosurveillance. Thus, effectively activating therapy‐induced ICD of great clinical significance raise systemic immunity eradicate post‐treatment/abscopal tissues. Enhanced cytotoxic reactive oxygen species (ROS) generation in therapy has been positively correlated induction, which inspires design a amplifier. The nanohybrid...
Therapeutic nanocatalysis has emerged as an intriguing strategy for efficient cancer-specific therapy, but the traditional inorganic nanocatalysts suffer from low catalytic efficiency and difficulty in biodegradation, hindering their further clinical translation. Herein, a tumor microenvironment-triggered, biodegradable biocompatible nanocatalyst employing 2D hydroxide nanosheet is presented, shown to have high capacity efficiently produce abundant hydroxyl radicals under microenvironment...
Abstract Synthetic nano/micromotors are a burgeoning class of materials with vast promise for applications ranging from environmental remediation to nanomedicine. The motility these motors is generally controlled by the concentration accessible fuel, and therefore, engineering speed‐regulation mechanisms, particularly using biological triggers, remains continuing challenge. Here, control over movement superassembled porous framework micromotors via reversible, biological‐relevant...
Sequential control of exogenous chemical events inside cells is a promising way to regulate cell functions and fate. Herein we report DNA nanocomplex containing cascade DNAzymes promoter-like Zn-Mn-Ferrite (ZMF), achieving combined gene/chemo-dynamic therapy. The ZMF decomposed in response intratumoral glutathione release sufficient quantity metal ions, thus promoting DNA/RNA cleavage free radical generation. Two kinds were designed for sequential enzymatic reaction, which ions functioned as...
Metastasis is the primary cause of cancer morbidity and mortality. To obtain an effective diagnosis treatment, precise imaging tumor metastasis required. Here we prepared persistent luminescent nanoparticles (PLNPs) containing a hydrogel (PL-gel) for targeted, sustained, autofluorescence-free imaging. PLNPs offered renewable long-lasting near-infrared (NIR) emitting without in situ radiation, favoring deep tissue penetration background interference. were conjugated with 4-carboxyphenyl...
Abstract The design of controllable dynamic systems is vital for the construction organelle‐like architectures in living cells, but has proven difficult due to lack control over defined topological transformation self‐assembled structures. Herein, we report a DNA based assembly system that achieves lysosomal acidic microenvironment specifically inducing from nanoparticles hydrogel architecture cells. Designer are constructed double‐stranded with cytosine‐rich stick ends (C‐monomer) and...
Nanovaccines have emerged as promising alternatives or complements to conventional cancer treatments. Despite the progresses, specific co-delivery of antigen and adjuvant their corresponding intracellular destinations for maximizing activation antitumor immune responses remains a challenge. Herein, lipid-coated iron oxide nanoparticle is delivered nanovaccine (IONP-C/O@LP) that can co-deliver peptide (CpG DNA) into cytosol lysosomes dendritic cells (DCs) through both membrane fusion...