A5100740257- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Sodium Intake and Health
- Layered Double Hydroxides Synthesis and Applications
- Electrolyte and hormonal disorders
- Liver Disease Diagnosis and Treatment
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Advanced Photocatalysis Techniques
- Supramolecular Self-Assembly in Materials
- Cancer Mechanisms and Therapy
- Supramolecular Chemistry and Complexes
- Drug Solubulity and Delivery Systems
- Polyoxometalates: Synthesis and Applications
- Carbon Nanotubes in Composites
- RNA Interference and Gene Delivery
- Viral-associated cancers and disorders
- Magnetic Properties and Synthesis of Ferrites
- Sulfur Compounds in Biology
- Water Treatment and Disinfection
- Heavy Metals in Plants
Vanderbilt University Medical Center
2024-2025
The University of Queensland
2014-2025
Princess Alexandra Hospital
2016-2025
Guangzhou Institute of Energy Conversion
2024
Greenslopes Private Hospital
2016-2020
Brisbane School of Theology
2015
Peking University
2006-2014
Hong Kong Polytechnic University
2011
Beijing National Laboratory for Molecular Sciences
2010
Anhui Provincial Hospital
1995
We introduced a new strategy of albumin pre-coating to effectively stabilise layered double hydroxide (LDH) nanoparticles for biomedical applications.
Distal tubular sodium retention is a potent driver of hypertension, and the thiazide–sensitive sodium-chloride cotransporter (NCC) has key role in this process. In humans, factors regulating NCC are unclear, but animal models, aldosterone regulator, possibly via effects on plasma potassium. We studied mineralocorticoid fludrocortisone abundance its phosphorylated form (pNCC) as well WNK lysine deficient protein kinase 4 (WNK4) STE20/SPS1–related, proline alanine–rich (SPAK) human urinary...
ABSTRACT Aim Using urinary extracellular vesicles (uEVs), we have demonstrated the functional ‘renal‐K switch’ mechanism (the WNK‐SPAK‐NCC pathway) in both healthy subjects and those with primary aldosteronism. The close relationship between blood pressure CKD has led to hypothesis that high potassium intake may be reno‐protective through same mechanism. This study used uEVs evaluate whether plasma negatively correlates NCC its phosphorylation (pNCC) patients CKD. Methods Morning second...
The putative "renal-K switch" mechanism links dietary potassium intake with sodium retention and involves activation of the chloride (NaCl) cotransporter (NCC) in distal convoluted tubule response to low intake, suppression high intake. This study examined NCC abundance phosphorylation (phosphorylated [pNCC]) urinary extracellular vesicles (uEVs) isolated from healthy adults on a diet determine tubular responses alteration (KCl) intake.Healthy maintained (∼4.5 g [200 mmol]/d) (∼2.3 [60...
The synthesis method of layered double hydroxides (LDHs) determines nanoparticles’ performance in biomedical applications. In this study, hydrothermal treatment as an important technique has been examined for its influence on the physicochemical properties and drug release rate from drug-containing LDHs. We synthesised MgAl–LDHs intercalated with non-steroidal anti-inflammatory drugs (i.e., naproxen, diclofenac ibuprofen) using a co-precipitation or without (150 °C, 4 h). After being...
We assessed hemoglobin affinity for oxygen (standard P50: pH 7.40, PCO2 40 Torr, temperature 37 degrees C) in 3 series of studies 16 male subjects who performed exhaustive treadmill exercise 10 min duration. Standard P50 was significantly elevated (0.7--2.5 Torr) during the last minute and 30 following exercise. Exercise while carboxyhemoglobin (HbCO) acutely to 5% did not affect std any differently than alone. 2,3-Diphosphoglycerate (2,3-DPG) after exercise, but or postexercise, it...
Air-stable magnetic cobalt nanocrystals have been conveniently prepared via a reverse micellar synthesis, followed by hydrothermal treatment. The synthesis was carried out first mixing an aqueous solution containing chloride and poly(sodium 4-styrenesulfonate) (PSS) with organic mixture cetyltrimethylammonium bromide (CTAB) to form micelles, reducing ions sodium borohydride. resultant nanoparticles were then undergone treatment at 165 °C for 8 h generate well-dispersed CTAB/PSS-encapsulated...
Key Points Volume expansion induced a clear reduction in aquaporin 2 abundance urinary extracellular vesicles. Changes sodium-chloride cotransporter (NCC) and phosphorylated NCC may have been primarily due to diluted post-test urine samples stable plasma potassium during the test. Background Sodium chloride (NaCl) loading volume suppress renin-angiotensin-aldosterone system reduce renal tubular reabsorption of NaCl water, but effects on relevant transmembrane proteins that are responsible...
Key Points Potassium chloride intake induced a reduction in sodium-chloride cotransporter (NCC) and phosphorylated NCC urinary extracellular vesicles from patients with primary aldosteronism during significantly raised level of endogenous aldosterone. Low plasma potassium (secondary to aldosterone excess) may dominate terms regulation the setting aldosteronism. Background Elevated abundance (pNCC) are potential markers (PA), but these effects be driven by hypokalemia. Methods We measured PA....
The formation of β- and γ-cyclodextrin (CD) nanotubes induced by the molecule 4,4′-bis(2-benzoxazolyl) stilbene (BOS) was investigated fluorescence anisotropy. Using Perrin–Webber formula, average number cyclodextrin (n CD ) in each nanotube estimated results suggested that n value γ-CD system is larger than β-CD system. Hydrogen-bonding between hydroxyl groups neighboring CDs found to be an important contribution on basis pH effect study. temperature study showed this thermostable at T ≤...
Inadequate dietary potassium (K