A5088078185- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Redox biology and oxidative stress
- Supramolecular Self-Assembly in Materials
- Autophagy in Disease and Therapy
- DNA and Nucleic Acid Chemistry
Beijing National Laboratory for Molecular Sciences
2025
University of Chinese Academy of Sciences
2025
Institute of Chemistry
2025
Tianjin University
2021-2022
Sequential control of exogenous chemical events inside cells is a promising way to regulate cell functions and fate. Herein we report DNA nanocomplex containing cascade DNAzymes promoter-like Zn-Mn-Ferrite (ZMF), achieving combined gene/chemo-dynamic therapy. The ZMF decomposed in response intratumoral glutathione release sufficient quantity metal ions, thus promoting DNA/RNA cleavage free radical generation. Two kinds were designed for sequential enzymatic reaction, which ions functioned as...
Abstract Intracellular accumulation of reactive oxygen species (ROS) leads to oxidative stress, which is closely associated with many diseases. Introducing artificial organelles ROS-imbalanced cells a promising solution, but this route requires nanoscale particles for efficient cell uptake and micro-scale long-term retention, meets dilemma. Herein, we report deoxyribonucleic acid (DNA)-ceria nanocomplex-based dynamic assembly system realize the intracellular in-situ construction peroxisomes...
Subcellular inter-organellar crosstalk among lysosome, endoplasmic reticulum (ER), and mitochondrion is crucial for cancer cell survival a promising target in treatment; however, efficiently disrupting these interactive networks challenging. Herein, communication interception strategy presented, which specifically disrupts by lysosomal contents leakage along with their trajectory pre-activates autophagic flux to augment the lysosome-associated autophagy blocking preventing self-repair of...
Abstract Sequential control of exogenous chemical events inside cells is a promising way to regulate cell functions and fate. Herein we report DNA nanocomplex containing cascade DNAzymes promoter‐like Zn‐Mn‐Ferrite (ZMF), achieving combined gene/chemo‐dynamic therapy. The ZMF decomposed in response intratumoral glutathione release sufficient quantity metal ions, thus promoting DNA/RNA cleavage free radical generation. Two kinds were designed for sequential enzymatic reaction, which ions...