A5100715288- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Per- and polyfluoroalkyl substances research
- Nitric Oxide and Endothelin Effects
- Respiratory viral infections research
- Reconstructive Surgery and Microvascular Techniques
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Ion Channels and Receptors
- Nanoparticle-Based Drug Delivery
- Telomeres, Telomerase, and Senescence
- Facial Nerve Paralysis Treatment and Research
- Pregnancy and Medication Impact
- Hemodynamic Monitoring and Therapy
- Sulfur Compounds in Biology
- Immune Cell Function and Interaction
- Eicosanoids and Hypertension Pharmacology
- Chromosomal and Genetic Variations
- Electrical and Bioimpedance Tomography
Baise University
2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
XinHua Hospital
2009-2024
Shanghai Jiao Tong University
2012-2024
Shanghai Children's Hospital
2024
University School
2023
University of Hong Kong
2023
Hang Seng University of Hong Kong
2023
Ruijin Hospital
2012-2019
First Bethune Hospital of Jilin University
2018
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been reported to suppress immune function. However, previous studies on prenatal exposure PFASs allergic disorders in offspring provided inconsistent results. We aimed examine the association between childhood atopic dermatitis (AD) up 24 months of age. A prospective birth cohort study involving 1056 pregnant women was conducted two hospitals Shanghai from 2012 2015. Prenatal information collected by an interview with medical...
The COVID-19 pandemic have impacts on the prevalence of other pathogens and people's social lifestyle. This study aimed to compare pathogen, allergen micronutrient characteristics pediatric inpatients with pneumonia prior during in a large tertiary hospital Shanghai, China. Patients admitted Department Pediatric Pulmonology Xinhua Hospital between March-August 2019 2020 were recruited. And clinical patients compared those 2020. Hospitalizations for decreased by 74% after pandemic. For...
Pseudomonas aeruginosa ( P. ) is an opportunistic pathogen that can be found in individuals which the immune system has been suppressed by HIV/AIDS or chronic alcoholism. We evaluated role of inducible nitric oxide synthase (NOSII) as a modulator lung concentrations normal rats and given single dose ethanol (ETOH). Rats were pretreated with either sterile saline (PBS, 0.1 ml/kg, iv) NOS II inhibitor L‐N 6 ‐iminoethyl lysine (LNIL, 10 mg/kg, 15 min before intraperitoneal administration PBS...
Cold air stimulus is an important environmental factor that exacerbates asthma. At the molecular level, transient receptor potential melastatin 8 (TRPM8) plays a crucial part in cold detection. The roles of TRPM8 airway inflammation and remodeling murine model asthma with related mechanism are largely unknown. In this study, C57BL/6 mice were randomly divided into four groups: phosphate-buffered saline control group (control), ovalbumin (OVA)-induced (OVA), OVA (OVA+cold), OVA+cold+shTRPM8...
Our objective was to investigate the distributions of six single nucleotide polymorphisms (SNPs) MS4A2 E237G, C-109T, ADRB2 R16G, IL4RA I75V, IL4 C-590T, and IL13 C1923T in Mauritian Indian Chinese Han children with asthma. This case-control association study enrolled 382 unrelated children, 193 asthma 189 healthy controls, 384 192 controls. The SNP loci were genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism for samples TaqMan real-time quantitative PCR...
IL13, IL4, IL4RA, FCER1B, and ADRB2 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there gene-gene interactions in the five among asthmatic children of Chinese Han nationality.Nine single-nucleotide polymorphisms (SNPs) were genotyped 1,000 healthy controls using TaqMan real-time quantitative polymerase chain reaction. Multifactor-dimensionality reduction method was applied for analysis.A four-way interaction model...
Alzheimer's disease (AD) is a multifactor that has been reported to have close association with type 2 diabetes (T2D) where the v-akt murine thymoma viral oncogene homolog 1 (AKT1) plays an important role in protein synthesis pathways and cell apoptosis processes. Evidence shown AKT1 may be related AD risk among patients T2D. The aim of this study was analyze potential between single nucleotide polymorphisms promoter T2D assessed 574 consecutive unrelated subjects including 112 T2D, 231 AD,...
Increasing evidence shows that antibiotic use in pregnancy may increase the risk of childhood asthma but epidemiologic studies are still limited and findings inconsistent. Meanwhile, exclusive prolonged breastfeeding prevent children from allergic diseases. We aimed to assess association between prenatal asthma, explore whether modifies risk.We conducted a case-control study Shanghai, China, June 2015 January 2016. A total 634 cases 864 controls aged 3-12 years were included. Multiple...
An established technology to create cloned animals is through the use of somatic cell nuclear transfer (SCNT), in which reprogramming nucleus a totipotent state by enucleated oocyte cytoplasm necessary process, including telomere length reprogramming. The limitation this technology; however, that live birth rate offspring produced SCNT significantly lower than IVF. Whether and how play role development not well understood. Only few studies have evaluated association mice, fewer still cows....
Background: Research increasingly suggests that asthma is a familial and hereditary disorder genetic environmental factors play key role in its pathogenesis. Objective: The aim of this study was to investigate the associations between 10 single nucleotide polymorphism (SNP) loci development children from Mauritian population. Methods: population consisted 193 with 189 healthy controls Asthma diagnosed accordance American Thoracic Society criteria. TaqMan real-time quantitative polymerase...
Polymeric micelles (∼10 nm) have been prepared from the amphiphilic oligomer comprising oligomeric polystyrene as hydrophobic inner core and half of EDTA (–N(CH2COOH)2) hydrophilic outermost shell. After chelating cisplatin with –N(CH2COOH)2 in water, polymeric containing Pt on spherical surface easily obtained. Since chelate group is introduced into terminal by a RAFT agent, chelation PS(COOH)2 almost stoichiometric. The drug carrier based showed high loading efficiency (>70%) towards...
Background. Increasing research is available verifying that asthma a familial and hereditary disorder of complex factors genes. Objective. To investigate the single combined associations five nucleotide polymorphism loci in three genes with development children Chinese Han Nationality. Methods. A total 192 an equal number control subjects were recruited this study. Asthma was diagnosed accordance American Thoracic Society criteria. Polymerase chain reaction-restriction fragment length used...
Asthma is a complex and heterogeneous disease. We found gene-gene interactions between IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, FCER1B rs569108 in asthmatic Chinese Han children. This 4-locus set constituted an optimal statistical interaction model. examined associations the 4-gene model (IL13, IL4, FCER1B, ADRB2) Predictive Index (API) atopy children.Four single-nucleotide polymorphisms 4 genes were genotyped 385 preschool children with wheezing symptoms using matrix-assisted laser...
The 2016 guideline on the work-up of primary aldosteronism recommended that patients with obstructive sleep apnea–hypopnea syndrome (OSAS) be screened. This study aimed to identify clinical characteristics snoring (PA) complicated by OSAS. Sixty-eight self-reported or witnessed and 609 non-snoring diagnosed PA between 2010 2015 were recruited in this retrospective study. Compared patients, had significantly (P < 0.05) higher body mass index (BMI), diastolic blood pressure (DBP), serum...
A number of studies have examined the association between mold exposure and childhood asthma. However, conclusions were inconsistent, which might be partly attributable to lack consideration gene function, especially key genes affecting pathogenesis Research on interactions asthma is still very limited. We therefore whether there an interaction inflammation-related asthma.A case-control study with 645 asthmatic children 910 non-asthmatic aged 3-12 years old was conducted. Eight single...
Abstract Background IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma atopy. Our previous study has found gene–gene interactions on between these in Chinese Han children. Whether the begin fetal stage, whether interact with prenatal environment to enhance cord blood IgE (CBIgE) levels then cause subsequent allergic diseases have yet be determined. This aimed determine there gene-environment CBIgE elevation among aforementioned five environmental factors population. Methods...
Interleukin (IL)-13 plays an important role in the pathogenesis of asthma. A polymorphic variant human IL-13 R130Q, results substitution arginine with a glutamine was shown to be associated asthma Chinese Han nationality. We examined functional consequences this vitro investigate whether enhanced activity compared wild type IL-13. The wild-type and mutant genes were amplified from plasmid pET22b-hIL-13 by PCR site-directed mutagenesis PCR. Both product vector pET28a(+) digested NdeI BamHI....
Previous studies reported that history of pregnancy and delivery family environment might influence cord blood IgE (CB-IgE) levels development allergies; however, the association between them is not well-established. This study aimed at investigating level in newborn's umbilical its relationship with maternal, fetal, environmental factors.A total 989 mothers their infants were analyzed this study. Mothers given a questionnaire had series questions to evaluate demographic information,...
As the Golden Standard for clinical pulmonary function examination, spirometer examination requires a facemask and nose clip to be worn. It generally takes half an hour or more examine one patient. In addition, it needs operator having rich experiences patients cooperate well. A convenient effective evaluation tool is strongly demanded in routine examination. Existing research results suggest that, thoracic impedance varies with vital capacity shows good correlation capacity. Thoracic...