A5101573514- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- COVID-19 and healthcare impacts
- Congenital Diaphragmatic Hernia Studies
- COVID-19 Clinical Research Studies
- Infant Health and Development
- Ion Channels and Receptors
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Respiratory viral infections research
- Hydrogen's biological and therapeutic effects
- Cystic Fibrosis Research Advances
- Circadian rhythm and melatonin
- COVID-19 Impact on Reproduction
- Respiratory Support and Mechanisms
XinHua Hospital
2018-2024
Shanghai Jiao Tong University
2018-2024
Fudan University
2008
The COVID-19 pandemic have impacts on the prevalence of other pathogens and people's social lifestyle. This study aimed to compare pathogen, allergen micronutrient characteristics pediatric inpatients with pneumonia prior during in a large tertiary hospital Shanghai, China. Patients admitted Department Pediatric Pulmonology Xinhua Hospital between March-August 2019 2020 were recruited. And clinical patients compared those 2020. Hospitalizations for decreased by 74% after pandemic. For...
Cold air stimulus is an important environmental factor that exacerbates asthma. At the molecular level, transient receptor potential melastatin 8 (TRPM8) plays a crucial part in cold detection. The roles of TRPM8 airway inflammation and remodeling murine model asthma with related mechanism are largely unknown. In this study, C57BL/6 mice were randomly divided into four groups: phosphate-buffered saline control group (control), ovalbumin (OVA)-induced (OVA), OVA (OVA+cold), OVA+cold+shTRPM8...
Abstract Background IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma atopy. Our previous study has found gene–gene interactions on between these in Chinese Han children. Whether the begin fetal stage, whether interact with prenatal environment to enhance cord blood IgE (CBIgE) levels then cause subsequent allergic diseases have yet be determined. This aimed determine there gene-environment CBIgE elevation among aforementioned five environmental factors population. Methods...
Asthma is one of the most common chronic diseases affecting children's health, and recurrent wheezing in infants closely related to childhood asthma. However, up now, there a lack unified diagnostic criteria interventions for infants. By analyzing discussing risk factors intervention measures, we aim take individualized treatment different children reduce occurrence infants.From January 2017 December 2020, under 3 years old who were admitted Department Pediatric Respiratory Xinhua Hospital...
Abstract Background No reliable biological marker for the diagnosis of asthma in younger children is currently available. In this study, we analyzed differences basophil activation test (BAT) results among with recurrent wheezing episodes who had different outcomes. Results A prospective cohort study was conducted aged under 5 years visited our pediatric respiratory clinic and ward wheezing. After enrollment, participants provided samples a CD63-based BAT performed using an inhalant allergen...
Abstract Background: The COVID-19 pandemic have impacts on the prevalence of other pathogens and people’s social lifestyle. This study aimed to compare pathogen, allergen micronutrient characteristics pediatric inpatients with pneumonia prior during in a large tertiary hospital Shanghai, China. Methods: Patients admitted Department Pediatric Pulmonology Xinhua Hospital between March-August 2019 2020 were recruited. And clinical patients compared those 2020. Results: Hospitalizations for...
Abstract Background Our previous study has developed a four‐gene model involving IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 associated with asthma atopy in Chinese Han children. However, whether the gene is allergies early life yet to be determined. This aimed apply birth cohort investigate its associations development of allergic diseases toddlers. Methods Five hundred ninety‐seven children from completing 2‐year follow‐up were included. Epidemiologic information cord...
Wheezing is common in younger children and often related to viral infection. It lack of reliable indicators for asthma prediction.To evaluate the relationship between circulation CD4+CCR6+CRTh2+ memory Th2 cells diagnosis wheezing children.A prospective study was performed under 5 years old presented with or at last one episode documented history. After inclusion, level serum allergen-specific IgE (sIgE) circulating CD4+CCR6+CRTh2+cells were detected. The patients' personal family histories...
Abstract Cystic Fibrosis (CF) is primarily a progressive lung disease, characterized by chronic pulmonary infections with opportunistic pathogens. Such typically commence early in life, producing an inflammatory response marked IL‐8 chemokine production and neutrophilic infiltration, major contributory factors CF progression. Studying this inflammation, especially critical for developing new strategies preventing or slowing disruption to the structural integrity of airways. However,...
Objective Early studies had confirmed that the combine-sequential therapy in treatment of acute attacks wheezing infants was safe and effective, this study aims to further explore role oral azithromycin therapy. Methods According principles randomized, 56 were divided into Azithromycin group control from Aug.2012 Apr.2013, there 29 children 27 group.The protocol 10 mg/(kg·d), 3 days; prednisone 5 mg/d, Tulobuterol Patch 0.5 7 Ioratadine mL/d, Montelukast 4 days.Control without...
Background: The COVID‐19 pandemic have impacts on the prevalence of other [pathogen](javascript:;)s and people’s social lifestyle. This study aimed to compare [pathogen](javascript:;), allergen micronutrient characteristics pediatric inpatients with pneumonia prior during COVID-19 in a large tertiary hospital Shanghai, China. Methods: Patients admitted Department Pediatric Pulmonology Xinhua Hospital between March-August 2019 2020 were recruited. And clinical patients compared those 2020....
Objective To investigate the treatment of infant wheezing during acute phase in pediatric outpatient departments two tertiary hospitals and secondary Shanghai. Methods Simple random sampling method was adopted.Standardized questionnaires were given to parents physicians infants who suffered survey methods (Xinhua Hospital, Shanghai Children′s Medical Center)and (Putuo District People′s Renhe Hospital) from February May 2015 area.All data analyzed by using SPSS 20.0 software.The...
Background：Wheezing is an important respiratory symptom in the diagnosis of asthma. However, wheezing common children and often related to viral infection. This lack reliable biological indicators for asthma create difficulty diagnosing early children. Objective: In this study, levels CD4+CCR6+CRTh2+ memory Th2 cells with different diagnostic outcomes were investigated determine correlation a assess their potential clinical value as indicator disease. Methods: A prospective study was...