A5100682878- Hemoglobin structure and function
- Parathyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Biomarkers in Disease Mechanisms
- Protist diversity and phylogeny
- Cancer, Hypoxia, and Metabolism
- Genetic Syndromes and Imprinting
- FOXO transcription factor regulation
- Connective Tissue Growth Factor Research
- Estrogen and related hormone effects
- Glutathione Transferases and Polymorphisms
- Prostate Cancer Treatment and Research
First Affiliated Hospital of Zhengzhou University
2012-2025
Abstract Context and Objective Parathyroid carcinoma (PCa) is a rare endocrine neoplasm known for its high recurrence. The specific molecular properties influencing the prognosis of PCa remain largely elusive. present study was designed to explore significance PI3K/AKT/mTOR activation in PCa. Methods Over 10-year period, 64 patients were recruited from dual centers. We analyzed mTORC1 activity 29 controls, comprising atypical parathyroid tumor (APT), adenoma (PAd) normal (PaN) tissues. A...
Objective To explore the expression and significance of haptoglobin(Hp)in papillary thyroid carcinoma. Methods Reverse transcriptase-polymerase chain reaction(RT-PCR) Western blotting were applied to detect Hp in 112 cases carcinoma,67 benign node 50 normal tissues. Results The relative value mRNA was(0. 913±0. 102)in carcinoma tissues, which over-expressed comparing with node(0. 357±0. 009)and tissue(0. 296±0. 008) groups(P 0. 05).In addition,although level increased higher...
Objective To explore the role of haptoglobin in papillary thyroid carcinoma by applying tissue microarraies.Methods We constructed microarraies with 11 carcinomas,67 benign nodes and 50 normal tissues.Immunohistochemical method was applied to detect expression carcinoma,benign node tissues.Results In 112 cases carcinomas,the positive rate 79％.Papillary samples expressed much higher levels than (12％) thyroids (8％,P ＜0.05).However,there no statistically significant difference between tissues...
Objective To explore the station of glutathione peroxidase 3 (GPX3) promoter region methylation in papillary thyroid carcinoma (PTC) and analyze relationship between expression GPX3 its methylation.Methods Methylation-specific polymerase chain reaction (MSP) was employed to detect gene 47 samples,10 non-cancerous tissues cell line TPC-1.By using reverse transcription (RT-PCR) mRNA wad detected TPC-1 cells.Results 48.9％ (23/47) PTC methylated,while none 10 methylated.The hypermethylated...