A5101626695- Viral Infections and Vectors
- Food Allergy and Anaphylaxis Research
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Vector-Borne Animal Diseases
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Mosquito-borne diseases and control
- Drug-Induced Adverse Reactions
- Antibiotics Pharmacokinetics and Efficacy
- Systemic Lupus Erythematosus Research
- COVID-19 epidemiological studies
- Asthma and respiratory diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Animal Virus Infections Studies
- Thermal Regulation in Medicine
- Viral gastroenteritis research and epidemiology
- Enhanced Recovery After Surgery
- Cystic Fibrosis Research Advances
- Berberine and alkaloids research
- Dermatological and COVID-19 studies
- Balance, Gait, and Falls Prevention
Capital Institute of Pediatrics
2024
Peking Union Medical College Hospital
2008-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
China-Japan Friendship Hospital
2020-2024
Harbin Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Janssen (United States)
2024
Northeast Forestry University
2024
Institute of Microbiology
2020-2023
Seoul National University
2023
Objective Coagulopathy is one of the characteristics observed in critically ill patients with coronavirus disease 2019 (COVID‐19). Antiphospholipid antibodies (aPLs) contribute to coagulopathy, though their role COVID‐19 remains unclear. This study was undertaken determine prevalence and aPLs COVID‐19. Methods Sera collected from 66 who were 13 not tested by chemiluminescence immunoassay for anticardiolipin (aCLs), anti–β 2 ‐glycoprotein I (anti‐β GPI) (IgG, IgM, IgA), IgG anti‐β GPI–domain...
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne bunyavirus, causes mild-to-moderate infection to critical illness or even death in human patients. The effect of variations on virulence and related clinical significance is unclear. We prospectively recruited SFTSV-infected patients a hotspot region SFTS endemic China from 2011 2020, sequenced whole genome SFTSV, assessed the association genomic variants data, viremia, inflammatory response. identified seven...
Background The natural history of disease in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remained obscure during the early pandemic. Aim Our objective was to estimate epidemiological parameters (COVID-19) and assess relative infectivity incubation period. Methods We estimated distributions four SARS-CoV-2 transmission using a large database COVID-19 cases potential pairs cases, assessed their heterogeneity by demographics, epidemic phase geographical...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease high mortality, however no effective therapy available.The effect of favipiravir (FPV) in treating SFTS was evaluated by integrated analysis on data collected from a single-arm study (n=428), surveillance (n=2350) and published randomized controlled trial (n=145). A 1:1 propensity score matching performed to include 780 patients: 390 received FPV supportive only. Case fatality rates (CFRs), clinical...
To determine whether glucocorticoids can improve clinical outcomes of severe fever with thrombocytopenia syndrome (SFTS) patients, and how to identify patients who may benefit from the treatment.A retrospective study was performed include confirmed SFTS designated hospitals. The effect in reducing case fatality rate (CFR) improving recovery evaluated by multivariate logistic regression models.A total 2478 eligible were analyzed, whom 331 received glucocorticoids. An integrated parameter...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease a high case fatality rate. Few studies have been performed on bacterial or fungal coinfections the effect of antibiotic therapy. A retrospective, observational study was to assess prevalence and in patients hospitalized for SFTSV infection. The most commonly involved microorganisms antimicrobial therapy were determined by site source total 1201 infection included; 359 (29.9%) had microbiologically confirmed...
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease high mortality. However, detailed analysis lacking to explore the complex effect of sex age or comorbidities. Methods: A retrospective cohort study was performed among 2,938 SFTS patients entered during 2011-2020 in Xinyang, China. The case fatality rate (CFR) estimated for their association sex, age, and comorbidities by an interactive way. difference immune response between explored dependent Results: An...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease a high case fatality rate. Key gaps remained as to the assessment of clinical picture in fatal cases.A retrospective study was performed on 496 patients SFTS. The dynamic pattern manifestations and laboratory indicators were delineated.The mean age cases 69.0 years (standard deviation: 9.3), 52.8% male. median course from onset death 11 (interquartile range: 10-13) days. A total (neutrophil %,...
Antinuclear antibodies (ANAs) predicting the safety and efficacy of patients with advanced non-small cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICIs) are still a matter debate considering previous studies showed quite different results based on ANA cut-off values. Thus, we investigated associations between titers ICIs. Moreover, also briefly discussed effects anti-thyroglobulin (ATG) anti-thyroid peroxidase (ATPO) ICIs.A total 159 Chinese confirmed to have...
Scrub typhus can produce multiple organ dysfunction syndrome (MODS). Early recognition of the patients at risk MODS would be helpful in providing timely management and reducing mortality. In all, 449 children with scrub were enrolled three hospitals Yunnan, China from January 2010 to 2015. The patients’ clinical status system was evaluated on day discharge hospital by using standard criteria. classified into present (64 cases, 14.3%) or absent (385 85.7%). Multivariate logistic regression...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease a high fatality rate. How the glucose level might affect clinical outcome remains obscure.A multicenter study was performed in 2 hospitals from 2011 to 2021. Patients SFTS and acute hyperglycemia (admission fasting plasma [FPG] ≥7 mmol/L), postadmission FPG <7 mmol/L but after admission), euglycemia (FPG throughout hospitalization) were compared for their progress outcomes.A total of 3225 patients included...
Anaphylaxis during anesthesia is a rare but often potentially life-threatening event for patients. Identifying culprit agents responsible anaphylaxis of great important avoiding potential re-exposure to allergens, it poses challenge anesthetists. This retrospective study aimed analyze the culprits patients with history perioperative referred an allergy clinic in China, and evaluate role diagnostic tests clinical practice.A total 145 (102 female/43 male) who attended Anesthesia Allergy Clinic...
In recent years, with the rapid development of China 's waterfowl breeding industry, number common infectious diseases in ducks has been increasing, resulting a high level morbidity and mortality duck diseases, which seriously affected industry caused huge economic losses.In this experiment, preparation preliminary application egg yolk antibody against duck-derived astrovirus were studied. study, PCR identification phylogenetic tree analysis used to inoculate embryos after gradient dilution...
<h2>Abstract</h2><h3>Background</h3> Perioperative anaphylaxis is relatively rare but can be life-threatening. The incidence in China unknown and may differ from other global geographic regions. This study was therefore designed to understand the of perioperative China. <h3>Methods</h3> We enrolled 112 tertiary care hospitals seven distinct areas mainland collected information about Ring Messmer III IV reactions September 2018 August 2019. A collaborative educational learning network used...
During the COVID-19 pandemic, analytics and predictive models built on regional data provided timely, accurate monitoring of epidemiological behavior, informing critical planning decision-making for health system leaders. At Atrium Health, a large, integrated healthcare in southeastern United States, team statisticians physicians created comprehensive forecast program that leveraged an array statistical methods. The utilized following methodological approaches; (i) exploratory graphics,...
Porcine reproductive and respiratory syndrome virus (PRRSV) critically threatens the pig industry in China. Lineage 1 PRRSV, which is divided into L1A–L1F L1H–L1J, widely recognized as most extensively genetically diverse lineage globally. L1A (NADC34-like) L1C (NADC30-like) PRRSVs have become current major circulating strains Notably, from other branches of L1 not been reported During our epidemiological investigation we identified a new strain named HLJDZD55. Phylogenetic analysis ORF5...
To explore the development of central nervous system (CNS) symptoms and clinical application in predicting outcomes SARS-COV-2 patients. A retrospective cohort study was performed on hospitalized patients with recruited from four hospitals Hubei Province, China 18 January to 10 March 2020. The CNS were determined. Data regarding laboratory tests collected medical records. Of 1268 studied, 162 (12.8%) had symptoms, manifested as unconsciousness (71, 5.6%), coma (69, 5.4%), dysphoria (50,...
Sierra Leone has one of the highest burdens febrile illnesses in world. As incidence malaria diminishes, a better understanding spectrum etiological agents was important for accurate diagnosis and empirical treatment illness. Blood, nasopharyngeal, fecal specimens were collected from patients serological, molecular detection, microbiologic culture to identify potential pathogens. For this prospective study, 142 enrolled. The prevalence higher children aged 5–15 years old (P = 0.185) adults...