A5050978519- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- Fire effects on ecosystems
- Thermal Regulation in Medicine
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Mast cells and histamine
- interferon and immune responses
- Digital Mental Health Interventions
- Climate Change and Health Impacts
- Plant Virus Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Sentiment Analysis and Opinion Mining
- Mental Health via Writing
Academy of Military Medical Sciences
2024
Guangzhou University
2024
Institute of Microbiology
2020-2023
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus causing a high fatality rate of up to 30%. To date, the receptor mediating SFTSV entry remained uncharacterized, hindering understanding disease pathogenesis. Here, C-C motif chemokine 2 (CCR2) was identified as host for based on genome-wide CRISPR-Cas9 screen. Knockout CCR2 substantially reduced viral binding and infection. enhanced through direct glycoprotein N (Gn), which mediated by its...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease high fatality. Poor prognosis of SFTS has been associated dysregulated host immunity; however, the immune patterns pathophysiology involving exacerbation remain unclear. Here, we show that single-cell landscape peripheral responses reprogrammed in and characterized by monocyte shift to intermediate type along complement activation, perturbation plasmablast composition, highly exhausted T cells, all...
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne bunyavirus, causes mild-to-moderate infection to critical illness or even death in human patients. The effect of variations on virulence and related clinical significance is unclear. We prospectively recruited SFTSV-infected patients a hotspot region SFTS endemic China from 2011 2020, sequenced whole genome SFTSV, assessed the association genomic variants data, viremia, inflammatory response. identified seven...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease high mortality, however no effective therapy available.The effect of favipiravir (FPV) in treating SFTS was evaluated by integrated analysis on data collected from a single-arm study (n=428), surveillance (n=2350) and published randomized controlled trial (n=145). A 1:1 propensity score matching performed to include 780 patients: 390 received FPV supportive only. Case fatality rates (CFRs), clinical...
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne bunyavirus a high pathogenicity. Little known about the longitudinal dynamics of SFTSV-specific neutralizing antibody (NAb) and related factors in patients SFTS.A prospective cohort study laboratory-confirmed SFTS were conducted. Antiglomerulonephritis-immunoglobulin G (anti-Gn-IgG) NAb titers examined serially collected serum samples, their dynamic features analyzed.NAb was initially detected at 15...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease a high fatality rate. How the glucose level might affect clinical outcome remains obscure.A multicenter study was performed in 2 hospitals from 2011 to 2021. Patients SFTS and acute hyperglycemia (admission fasting plasma [FPG] ≥7 mmol/L), postadmission FPG <7 mmol/L but after admission), euglycemia (FPG throughout hospitalization) were compared for their progress outcomes.A total of 3225 patients included...
One of the conserved mechanisms at stage genome transcription segmented negative-strand RNA viruses (sNSVs) is cap-snatching process, which vital for sNSVs and provides drugable targets development antivirals. However, specificity RNAs snatched by sNSV still unclear. By transcriptomics analysis whole blood samples from SFTS patients, we found WNT-CTNNB1 signaling pathway was regulated according to course disease. We then demonstrated that L protein severe fever with thrombocytopenia syndrome...
To explore the development of central nervous system (CNS) symptoms and clinical application in predicting outcomes SARS-COV-2 patients. A retrospective cohort study was performed on hospitalized patients with recruited from four hospitals Hubei Province, China 18 January to 10 March 2020. The CNS were determined. Data regarding laboratory tests collected medical records. Of 1268 studied, 162 (12.8%) had symptoms, manifested as unconsciousness (71, 5.6%), coma (69, 5.4%), dysphoria (50,...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic acquired by tick bites. Whether mast cells (MCs), the body's first line of defense against pathogens, might influence immunity or pathogenesis during SFTS virus (SFTSV) infection remained unknown. Here, we found that SFTSV can cause MC and degranulation, resulting in release vasoactive mediators, chymase, tryptase, which directly act on endothelial cells, break tight junctions threaten integrity microvascular...
Selenium deficiency can be associated with increased susceptibility to some viral infections and even more severe diseases. In this study, we aimed examine whether association applies fever thrombocytopenia syndrome (SFTS).An observational study was conducted based on the data of 13,305 human SFTS cases reported in mainland China from 2010 2020. The associations among incidence, case fatality rate SFTS, crop selenium concentration at county level were explored. a cohort patients tested, its...
Purpose Depression has become one of the most serious and prevalent mental health problems worldwide. The rise popularity social networks such as microblogs provides a wealth psychological data for early depression detection. Language use patterns reflect emotional states traits. Differences in language between depressed general users may help predict diagnose depression. Existing work focuses on detection using users' textual emotion expressions, with less psychology-related knowledge....
Severe fever with thrombocytopenia syndrome (SFTS), caused by novel bunyavirus (SFTSV), is a hemorrhagic high mortality rate of over 10%. We have previously shown that granulocytic myeloid-derived suppressor cell (gMDSC) might affect arginine metabolism, which was associated decreased platelet count and T lymphocyte dysfunction in this disease. The study designed to investigate the expression gMDSCs subsets SFTS patients, evaluate its association disease severity. A prospective performed on...
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic acquired by tick bites. Whether mast cells (MCs), the body’s first line of defense against pathogens, might influence immunity or pathogenesis during SFTS virus (SFTSV) infection remained unknown.Methods: MCs were infected SFTSV and its response to was assessed in vitro vivo . MC-specific proteases locally injected into mouse footpads back skin investigate effect on endothelial vascular damage...
Objective: To investigate the characteristics of disease transmission, diagnosis, and treatment COVID‑19 in children. Methods: We retrospectively studied 20 children with from 4 medical centers Hubei, China. Results: Among children, 18 (90.0%) were contaminated by close contact characterized family clustering. Seven cases (35.0%) had all members infected, 11 (55.0%) confirmed either parents infected. Twelve (60.0%) fever, which was primary symptom 10 (50.0%). Only one child severe degree...