A5017763265- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Plant Virus Research Studies
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Animal Disease Management and Epidemiology
Harbin Veterinary Research Institute
2015-2025
Chinese Academy of Agricultural Sciences
2015-2025
Porcine respiratory and reproductive syndrome virus (PRRSV) causes an economically important disease affecting commercial pork production worldwide. NADC34-like PRRSV has had a strong impact on the U.S. Peruvian pig industries in recent years also emerged northeastern China 2017. However, endemic status of is unclear. In this study, we examined 650 tissue samples collected from 16 Provinces 2018 to 2019. Six strains were detected three Provinces, complete genomes four these sequenced....
Multiple porcine reproductive and respiratory syndrome virus (PRRSV) subtypes coinfect numerous pig farms in China, commercial PRRSV vaccines offer limited cross-protection against heterologous strains. Our previous research confirmed that a lineage 1 branch attenuated live vaccine (SD-R) provides HP-PRRSV, NADC30-like NADC34-like PRRSV. HP-PRRSV has undergone significant genetic variation following nearly two decades of evolution transformed into subtype referred to as HP-like PRRSV, which...
The immunological effect of porcine reproductive and respiratory syndrome disease virus (PRRSV) vaccines is thought to be influenced by a variety host factors, in which antibody-dependent enhancement (ADE) infection one crucial factor. Here, we assessed the mechanism ADE PRRSV infection. First, found that subneutralizing serum could induce alveolar macrophages (PAMs). Quantitative PCR, Western blotting flow cytometry revealed CD16 most abundant Fcγ receptor (FcγR) expressed on surface PAMs;...
Porcine reproductive and respiratory syndrome virus (PRRSV) is an agent of porcine (PRRS), which causes substantial economic losses to the swine industry. PRRSV displays rapid variation, five lineages coexist in mainland China. Lineage 3 PRRSVs emerged China 2005 prevailed southern after 2010. In present study, two lineage strains, are named SD110-1608 SDWH27-1710, were isolated from northern 2017. To explore characteristics origins we divided into sublineages (3.1-3.5) based on 146 open...
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly variable with genetic diversity. This study comparatively examines the pathogenicity immunological impact of two emergent PRRSV strains, SD53 HuN4, in piglets. Our results indicate that strain induces milder clinical syndromes less severe tissue damage than despite similar replication rates. Hematological tests showed perturbations peripheral blood cell profiles after infection, suggesting systemic impact. The...
Porcine reproductive and respiratory syndrome virus (PRRSV) critically threatens the pig industry in China. Lineage 1 PRRSV, which is divided into L1A–L1F L1H–L1J, widely recognized as most extensively genetically diverse lineage globally. L1A (NADC34‐like) L1C (NADC30‐like) PRRSVs have become current major circulating strains Notably, from other branches of L1 not been reported During our epidemiological investigation we identified a new strain named HLJDZD55. Phylogenetic analysis ORF5...
Newly emerged sublineage 1.5 (NADC34-like) porcine reproductive and respiratory syndrome virus (PRRSV) has posed a direct threat to the Chinese pig industry since 2018. However, prevalence impact of NADC34-like PRRSV on farms is unclear. In present study, we continuously monitored pathogens, including PRRSV, African swine fever (AFSV), classical (CSFV), pseudorabies (PRV) circovirus 2 (PCV2), seven fattening with strict biosecurity practices located in five provinces China from 2020 2021....
Abstract Background Long noncoding RNA (lncRNA) is highly associated with inflammatory response and virus-induced interferon production. By far the majority of studies have focused on immune-related lncRNAs mice humans, but function in porcine immune cells are poorly understood. Porcine reproductive respiratory syndrome virus (PRRSV) impairs local responses lungs nursery growing pigs, whereas triggers responses. alveolar macrophage (PAM) primary target cell PRRSV, thus PRRSV used as an vitro...
Porcine reproductive and respiratory syndrome virus (PRRSV) is an important pathogen that endangers the swine industry worldwide. Recently, lineage 1 PRRSVs, especially NADC30-like PRRSV, have become major endemic strains in many pig-breeding countries. Since 2016, PRRSV has predominant strain China. Unfortunately, current commercial vaccines cannot provide sufficient protection against this strain. Here, attenuated strain, named SD-R, was obtained by passaging SD Marc-145 cells for 125...
Porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) is one of the main pathogens causing porcine (PRRS). In recent years, detection number PRRSV-1 in China has gradually increased, strains reported belong to subtype Ⅰ (Global; Clade A-L). present study, a novel strain, TZJ2134, was found during epidemiological surveillance Shandong Province China. We obtained two fragments TZJ2134: TZJ2134-L12 (located at nt 1672-nt 2112 partial Nsp2 gene) TZJ2134-(A+B) 7463-nt 11272 Nsp9,...