Abstract Background Long non-coding RNAs (lncRNAs) are not translated into proteins and were initially considered to be part of the ‘dark matter’ genome. Recently, it has been shown that lncRNAs play a role in recruitment chromatin modifying complexes can influence gene expression. However, is unknown if function similar way cancer. Results Here, we show lncRNA ROR occupies activates TESC promoter by repelling histone G9A methyltransferase promoting release H3K9 methylation. Suppression...

Abstract Kaempferol (kaem) is a dietary flavonoid found in variety of fruits and vegetables. The inhibitory effects kaem on primary tumour growth have been extensively investigated; however, its metastasis are largely unknown. In the present study, we that significantly suppresses both lung mouse breast model. Furthermore, decreased expression citrullinated histone H3 (H3‐cit), biomarker neutrophil extracellular traps (NETs), had founded metastatic upon treated with kaem. reduction H3‐cit...

Abstract Methyl jasmonate (MeJA) plays a role in improving plant stress tolerance. The molecular mechanisms associated with heat tolerance mediated by MeJA are not fully understood perennial grass species. study was designed to explore transcriptomic underlying exogenous ryegrass ( Lolium perenne L.) using RNA-seq. Transcriptomic profiling performed on plants under normal temperature (CK), high for 12 h (H), pretreatment (T), + H (T-H), respectively. analysis of differentially expressed...

To understand how forest gaps and the associated canopy control litter lignin cellulose dynamics by redistributing winter snow coverage hydrothermal conditions in growing season, a field litterbag trial was conducted alpine Minjiang fir (Abies faxoniana Rehder E.H. Wilson) transitional area located upper reaches of Yangtze River eastern Tibetan Plateau. Over first year decomposition, exhibited absolute loss accumulation except for red birch litter. The changes were significantly affected...

Ni, X., Yang, W., Li, H., Xu, L., He, J., Tan, B. and Wu, F. 2014. The responses of early foliar litter humification to reduced snow cover during winter in an alpine forest. Can. J. Soil Sci. 94: 453–461. Snow can be by ongoing warming biomes, affecting humification, but few reports are available. To quantitatively clarify how responds winter, a field litterbag experiment was conducted forest southwestern China. Mass losses, ΔlogK, E4/E6, degrees rates six typical local litters were...

Diallyl disulfide (DADS) is a major constituent of garlic. Previously, we found that DADS both inhibited proliferation in human gastric cancer cells vitro and vivo, induced G2/M arrest. In this study, investigated whether differentiation effect was by MGC803 cells, it related to an alteration ERK activity. The results showed the growth DADS. Cells treated with displayed lower nucleocytoplasmic ratio tended form gland intercellular conjunction structures. ConA-mediated cell agglutination...

Abstract Background Uveal melanoma (UM) is a severe human malignancy with high mortality rate, as well metastasis and recurrence potential. The active mutation of G protein subunit alpha q ( GNAQ ) or 11 GNA11 major trigger for UM. Oncolytic adenovirus H101 (H101) the first oncolytic virus approved clinical applications in cancer therapy by China Food Drug Administration. We investigated whether combining downregulation expression would act synergistically UM therapy. Methods Three cell...

The NAC transcription factor family is deemed to be a large plant-specific gene that plays important roles in plant development and stress response. Miscanthus sinensis commonly planted vast areas of marginal lang as forage, ornamental grass, or bioenergy crop which demand relatively high resistance abiotic stresses. recent release draft chromosome-scale assembly genome M. provided basic platform for the genome-wide investigation proteins. In this study, total 261 genes were identified...

Ni, X., Yang, W., Li, H., Xu, L., He, J., Tan, B. and Wu, F. 2014. The responses of early foliar litter humification to reduced snow cover during winter in an alpine forest. Can. J. Soil Sci. 94: 453-461. Snow can be by ongoing warming biomes, affecting humification, but few reports are available. To quantitatively clarify how responds winter, a field litterbag experiment was conducted forest southwestern China. Mass losses, ΔlogK, E4/E6, degrees rates six typical local litters were...

Uveal melanoma (UM) is the most common primary intraocular cancer in adults. Although diagnosis modality of UM was improved significantly, there are currently no effective therapies for metastatic UM. Hypermethylated 1 (HIC1) frequently deleted or epigenetically silenced various human cancers. However, role and mechanism HIC1 still unclear. In this study, we found that acted as a tumor suppressor its expression downregulated Functional studies demonstrated ectopic cells inhibited cell...

Osteoblasts are bone-forming cells that responsible for the production of bone extracellular matrix. Osteoradionecrosis is a complication radiation therapy carcinoma head and neck occurs in 3% to 8.2% irradiated patients. The irradiation effect on osteoblast differentiation has not been fully elucidated. objective our research was elucidate effects growth differentiation-related gene expression vitro. Three genes, alkaline phosphatase, type I collagen, osteocalcin, were tested experiment....

The stromal-cell-derived factor 1 (SDF-1)/chemokine receptor 4 (CXCR4) chemokine axis plays a key role in tumor migration. Here, we analyzed the uveal melanoma (UM) proliferation and migration investigated effect of chemical inhibitor CXCR4, AMD3100, on UM. We found that CXCR4 was expressed all five UM cell lines tested as well retinal pigment epithelium line ARPE-19 cells, while CXCR7 only detected OM290 VUP lines. SDF-1 promotes OCM-1 OCM431 lines, AMD3100 weakens this function. Taken...

Abstract Nitrogen is known to be a critical macro-nutrient influencing plant physiology, growth, and mineral composition. In tropical conditions, which are challenging for leafy vegetable farming, the nitrogen delivery effect unclear. this study, we aimed investigate of application on key physiological traits composition plants, ionome. Experiments were conducted under conditions greenhouse with varying levels supply examine transpiration, yield, use efficiency water nitrogen, nutrient...

Stafne bone cavity (SBC) is a rare mandibular defect, and the diagnosis management may be confused with unusual contents location. This report for first time presented case of SBC lymph node content. Meanwhile, anterior fatty tissue content reported. Typical SBCs salivary glands are asymptomatic showed well-shaped, ovoid, radiolucent image in posterior mandible below inferior alveolar canal panoramic radiograph. The underwent surgical operation, definite confirmed by histopathological...

The total phenol content in decomposing litter not only acts as a crucial quality indicator, but is also closely related to humification due its tight absorption clay particles. However, limited attention has been focused on the dynamics foliar relation forest gaps. Here, of six representative tree species was incubated floor from gap center closed canopy an alpine Minjiang fir (Abies faxoniana) upper reaches Yangtze River and eastern Tibetan Plateau. concentration measured November 2012...

Aims The release of heavy metals (such as Pb and Cd) from foliar litter play an important role in element cycling alpine forest ecosystems. Although natural gaps could roles the by affecting snow cover during winter solar irradiation growing season, few studies have examined these potential roles. objectives this study were to document changes Cd dynamics decomposition center under closed canopies investigate factors that controlled seasons. Methods Senesced six dominant species, including...

Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) involved cell division DNA repair. However, its biological function remains unclear. In present study, it was identified that ART3 highly expressed cells tissues compared with normal RPE line, adjacent tissue, respectively. Small interfering RNA short hairpin were used silence gene expression, revealed silencing inhibits...

A field experiment was conducted to investigate the effect of controlled-release fertilizer (CRF) combined with urea (UR) on soil fertility and environment in wheat-rice rotation system. Changes four forms nitrogen (total nitrogen, ammonium nitrate microbial biomass nitrogen) activities three enzymes participating transformation (urease, protease, reductase) were measured seven fertilization treatments (no fertilization, routine 10%CRF+90%UR, 20%CRF+80%UR, 40%CRF+60%UR, 80%CRF+20%UR,...

Aims Snow patches of varying thickness could play an important role in potassium (K) and sodium (Na) dy- namics during litter decomposition subalpine forests due to significant freeze-thaw events, but the detailed pro- cesses are unclear. Our objective was understand how snow would affect dynamics K Na six representative woody species different cover periods. Methods A field experiment conducted investigate a forest western Sichuan by using litterbag method. Air-dried Salix paraplesia, Larix...

Head and neck teratoid cysts are the least common congenital in head region, accounting for approximately 1.8% of all dermoid cysts. Teratoid exhibiting mesodermal elements may be lined by gastric, intestinal, respiratory, squamous, or cilitated epithelium. We present a case huge submandibular cyst newborn with airway obstruction feeding difficulty. Surgical extirpation is treatment choice. However, before operation, some other cystic diseases region needs to excluded. Fine-needle aspiration...

Objective: To evaluate the feasibility and short-term efficacy of a novel simplified closure method developed by our team for defect after endoscopic full-thickness resection (EFTR) gastric submucosal tumors (SMT) in wall. Methods: A prospective single-arm clinical study was used. Inclusion criteria: (1) lesion located fundus or greater curvature stomach, confirmed to originate from muscularis propria layer; (2) diameter tumor ≤3.5 cm, had no extensive adhesion peritoneal tissues organs...

Leukemia is a type of disease in which hematopoietic stem cells proliferate clonally at the genetic level. We discovered previously by high-resolution mass spectrometry that diallyl disulfide (DADS), one effective ingredients garlic, reduces performance RhoGDI2 from APL HL-60 cells. Although oversubscribed several cancer categories, effect has remained unexplained. aimed to investigate influence on DADS-induced differentiation elucidate association among inhibition or over-expression with...