A5101505665- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Pregnancy-related medical research
- Ovarian cancer diagnosis and treatment
- Hippo pathway signaling and YAP/TAZ
- Assisted Reproductive Technology and Twin Pregnancy
- Seaweed-derived Bioactive Compounds
- Toxin Mechanisms and Immunotoxins
- Plant Pathogens and Fungal Diseases
- PI3K/AKT/mTOR signaling in cancer
- DNA Repair Mechanisms
- Multiple and Secondary Primary Cancers
- Reproductive Biology and Fertility
- Kruppel-like factors research
- RNA modifications and cancer
- Nematode management and characterization studies
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Insect Pest Control Strategies
Integrated Chinese Medicine (China)
2024
Women's Hospital, School of Medicine, Zhejiang University
2008-2024
Zhejiang Hospital
2024
Second Affiliated Hospital of Zhejiang University
2024
Affiliated Hospital of Hangzhou Normal University
2022
Women's Hospital
2022
Institute of Plant Protection
2009-2016
Zhejiang University
2008-2014
Chinese Academy of Agricultural Sciences
2009
Ectopic endometrial stromal cells (ESCs) and M2 macrophages co-exist in the lesions of endometriosis participate occurrence progression endometriosis. However, interaction between ectopic ESCs M2-type macrophage polarization is poorly understood. This study aims to investigate effect exosomes released from on potential mechanism. Human THP-1 monocytic induced differentiation (M0) polarization. their were used stimulate macrophages. was examined by detecting CD163 ARG1 expression. Exosomal...
Adenomyomectomy has recently been considered the priority option for treatment of adenomyosis, however, surgical efficacy and modes are still debated. We aimed to evaluate laparoscopic adenomyomectomy using a double-flap method uterine diffuse adenomyosis when compared with conventional adenomyomectomy.Laparoscopic (group A, n = 48) B, 46) treat respectively. Visual analog scale (VAS), menstrual amount, serum CA125 levels, volume were comparatively analyzed in both groups.The VAS scores, at...
Oxidative phosphorylation is becoming increasingly important in the induction and development of endometriosis. Recently, it has been reported that ring finger protein 43 (RNF43) involved process oxidative phosphorylation, but mechanism remains unclear. Our investigation to delve into roles RNF43 endometriosis elucidate related mechanisms. We found was downregulated ectopic endometrial tissue primary stromal cells (ECESCs). Knockdown enhanced cell viability migration by activating eutopic...
Interleukin (IL)-34 plays a critical role in cell proliferation, differentiation, apoptosis, angiogenesis, inflammation and immunoregulation. Numerous diseases can be attributed to the dysregulation of IL-34 signaling. This study was performed investigate function pathogenesis endometriosis. Firstly, by enzyme linked immunoabsorbent assay, we found that IL-34, VEGF, MMP-2 MMP-9 were increased sera patients with Secondly, exposure promoted migration invasion eutopic endometrial stromal cells...
The purpose of this study was to integrate the existing expression profile data on endometriosis (EM)-related tissues in order identify differentially expressed genes. In study, three series raw were downloaded from GEO database. Differentially genes (DEGs) tissue types screened. GO, KEGG pathway enrichment analysis, core differential (CDGs) protein–protein interaction (PPI) network and weighted gene co-expression analysis (WGCNA) performed, finally, dysregulation Hippo ectopic endometrium...
This study was undertaken to examine whether there is an association between excision repair cross-complementation group 1 (ERCC1) and xeroderma pigmentosum D (XPD) protein expression levels response platinum-based chemotherapy in epithelial ovarian cancer (EOC). The cohort consisted of 91 consecutive patients suffering from stage III or IV disease primary EOC 1999 2004 at the Women's Hospital, School Medicine, Zhejiang University. There were 36 sensitive cases serous cancer, 27 resistant 15...
To investigate the role of mast cells in pathogenesis estrogen-mediated experimental endometriosis rats.Endometriosis model was established by transplanting autologous fragments uterus to inner surface abdominal wall 24 un-pregnant female Sprague Dawley rats. The rats were divided randomly into three groups (n=8 each group), and injected with different doses estrogen: high-dose group (200 μg·kg⁻¹·d⁻¹), low-dose (100 μg·kg⁻¹·d⁻¹) control (0 μg·kg⁻¹·d⁻¹). ovaries surgically removed groups....
S100 calcium-binding protein A6 (S100A6) is up-regulated in many malignancies and overexpression of S100A6 has been identified associated with proliferation, migration invasion phenotype several cancer cells. In the present study, we explored whether plays a role development endometriosis. Significantly higher levels mRNA expression were observed ectopic endometrial tissues compared to eutopic normal tissues. Silencing stromal cells (ESCs) significantly inhibited cell viability, invasion....
To investigate the effect of sodium cromoglycate on experimental endometriosis in rats.Endometriosis model was established 36 unpregnant female SD rats by transplanting autologous fragments endometrium to inner surface abdominal wall. The endometriotic lesions were measured a second laparotomy 2 weeks after surgery. Then randomly divided into four groups (n=8 each group) receive intraperitoneal injection different doses for weeks: high-dose group (20 mg·kg⁻¹·d⁻¹); low-dose (10 negative...
Objective To evaluate the quality of literatures and accuracy ultrasonography in diagnosis deeply infiltrating endometriosis(DIE).Methods The database Medline (1966 to 2009), excerpta medica (EMBASE, 1980 Chinese biological medicine on disc (CBMdisc, 1978 China national knowledge infrastructure (CNKI, 1979 2009) VIP for technology periodical (VIP, 1989 Cochrane library studies about ultrasound DIE were searched analyzed.Quality assessment diagnostic (QUADAS) items used literatures.The...
Abstract The behaviour of female adult Bemisia tabaci is observed for a period 20 min after initial contact with untreated cucumber leaves, or leaves either foliar systemically treated azadirachtin, to determine whether application azadirachtin affects the host‐evaluation and on differs between methods. Application deters settling whiteflies host plants. probe shorter duration less frequently but spend longer engage more in labial grooming than leaves. Behavioural transition probing other...
<title>Abstract</title> Exosomes play significant roles in immune responses, neurogenesis, and angiogenesis, directly impacting the progression symptomatic manifestations of endometriosis. This study aimed to investigate role exosomal miR-146a-5p pathogenesis Through high-throughput RNA sequencing qRT‒PCR, we revealed upregulation ectopic endothelial tissues, Gene Ontology (GO) analysis that has only one target, TNF receptor associated factor 6 (TRAF6). KEGG pathway indicated NF-κB signaling...
To review the diagnosis and treatment of interstitial pregnancy.Four cases with complicated pregnancy were diagnosed treated from January, 2004 to June, 2007 at Affiliated Obstetrics Gynecology Hospital, College Medicine, Zhejiang University. The clinical data follow-up records analyzed retrospectively.All 4 nulliparous patients misdiagnosed before operation. median age was 30 years (25-34 years), duration amenorrhea 48 days (37-58 days). concentrations serum beta-hCG 3245.5 IU/L (282-30729...
A 37-year-old woman was diagnosed with abdominal wall endometrioma in 2020. She underwent cesarean delivery 2013 and had stabbing pain her right lower abdomen during menstruation since 2016. The endometrioma, a 1.6-cm × 2.3-cm 7.0-cm mass the rectus abdominis muscle (Fig. 1), separate from original scar of 2).Fig. 2Endometrioma. extensive (2020).View Large Image Figure ViewerDownload Hi-res image Download (PPT) For an aesthetic incision better postoperative recovery, single-port endoscopic...