A5022529644- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Moyamoya disease diagnosis and treatment
- Cardiac Arrest and Resuscitation
- Neurosurgical Procedures and Complications
- Barrier Structure and Function Studies
- Neurological Complications and Syndromes
- Neonatal and fetal brain pathology
- Adenosine and Purinergic Signaling
- interferon and immune responses
- Acute Ischemic Stroke Management
- Epilepsy research and treatment
- Facial Nerve Paralysis Treatment and Research
- Bacterial Infections and Vaccines
- Trigeminal Neuralgia and Treatments
- Caveolin-1 and cellular processes
- Pregnancy-related medical research
- Cerebral Venous Sinus Thrombosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Family Caregiving in Mental Illness
- Social Media in Health Education
Loma Linda University
2018-2024
Bursa Yuksek Ihtisas Egitim Ve Arastirma Hastanesi
2019-2024
Sağlık Bilimleri Üniversitesi
2019-2024
University of Health Science
2021-2024
University of Health Sciences
2023
Bursa Technical University
2019-2020
Medical Education Institute
2017-2018
Neurological Surgery
2017-2018
University of Wisconsin–Madison
2017-2018
Accreditation Council for Graduate Medical Education
2017-2018
Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies indicated that Mas receptor activation initiates an anti-oxidative anti-apoptotic role the brain. However, whether can attenuate oxidative SAH remains unknown. To investigate beneficial effect of on induced by SAH, a total 196 rats were subjected endovascular perforation model SAH. AVE 0991 (AVE), selective agonist Mas, was...
Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilized MSG-606, selisistat, PGC-1α verify the neuroprotective effects MC1R. evaluated short- long-term neurobehavior Western blotting, immunofluorescence, Golgi staining techniques...
Subarachnoid hemorrhage (SAH) is a life-threatening subtype of stroke with high mortality and disabilities. Retinoid X receptor (RXR) has been shown to be neuroprotective against ischemia/reperfusion injury. This study aimed investigate the effects selective RXR agonist bexarotene on neuroinflammation in rat model SAH. Two hundred male Sprague-Dawley rats were used. The endovascular perforation induced Bexarotene was administered intraperitoneally at 1 h after SAH induction. To underlying...
C-C chemokine receptor type 1 (CCR1) and its endogenous ligand, CCL5, participate in the pathogenesis of neuroinflammatory diseases. However, much remains unknown regarding CCL5/CCR1 signaling blood-brain barrier (BBB) permeability after intracerebral hemorrhage (ICH).A total 250 CD1 male mice were used ICH was induced via autologous whole blood injection. Either Met-RANTES, a selective CCR1 antagonist, or Met-RANTES combined with Rac1 CRISPR activator administered to h ICH. Post-ICH...
Today, the internet is widely used to obtain any type of information. The use may facilitate healthcare professionals' education as well.We aimed evaluate content, accuracy, reliability and quality YouTube videos regarding intubation, one most important skills for professionals.Of 54,000 found using keyword 'intubation', first 50 were included in study. sources divided into three categories: academicians, professionals medical. view ratio, like video power index determine popularity while...
OBJECTIVE Cystic vestibular schwannomas (CVSs) are a subgroup of (VSs) that reported to be associated with unpredictable clinical behavior and unfavorable postoperative outcomes. The authors aimed review their experience microsurgical treatment CVSs in terms extent resection facial nerve (FN) function compare these outcomes those solid counterparts. METHODS Two hundred-eleven VS patients were treated surgically between 2006 2017. Tumors defined as cystic when preoperative neuroimaging...
Background: The care of critically ill patients is a strong indicator service quality provided in the emergency department. Since families are major social support sources, assessing family members’ needs may reduce their anxiety and depression owing to acute situation loved ones while improving patients’ recovery. Objective: We aimed evaluate expectations relatives formulate solutions improve department service. Methods: conducted prospective, cross-sectional survey 873 nontraumatic, who...
Abstract Background Cardiac arrest survivors suffer from neurological dysfunction including cognitive impairment. Cerebral mast cells, the key regulators of neuroinflammation contribute to neuroinflammation-associated dysfunction. Mast cell tryptase was demonstrated have a proinflammatory effect on microglia via activation microglial protease-activated receptor-2 (PAR-2). This study investigated potential anti-neuroinflammatory inhibition and underlying mechanism PAR-2/p-p38/NFκB signaling...
Abstract Background Mast cells play an important role in early immune reactions the brain by degranulation and consequent inflammatory response. Our aim of study is to investigate effects rh-relaxin-2 on mast underlying mechanisms a germinal matrix hemorrhage (GMH) rat model. Methods One hundred seventy-three P7 pups were subjected GMH intraparenchymal injection bacterial collagenase. Clodronate liposome was administered through intracerebroventricular (i.c.v.) injections 24 h prior inhibit...
Cognitive deficits are a devastating neurological outcome seen in survivors of cardiac arrest. We previously reported water electrolysis derived 67% hydrogen gas inhalation has some beneficial effects on short-term outcomes rat model global brain hypoxia-ischemia induced by asphyxia In the present study, we further investigated its protective long-term spatial learning memory function using same animal model. Water was either administered 1 hour prior to arrest for and at 1-hour...
Global cerebral ischemia-induced neuroinflammation causes neurofunctional impairment following cardiac arrest. Previous studies have demonstrated that the activation of protease-activated receptor-2 (PAR-2) contributes to neuroinflammation. In present study, we aimed determine potential treatment effect PAR-2 inhibition against in setting asphyxial CA (ACA) rats.A total 116 adult, male Sprague-Dawley rats were randomly divided into Sham (n = 18) and ACA 98) groups. Time course, short-term...