A5100336438- Angiogenesis and VEGF in Cancer
- Antimicrobial Peptides and Activities
- Cerebrovascular and Carotid Artery Diseases
- Protein Hydrolysis and Bioactive Peptides
- Cardiovascular Health and Disease Prevention
- Inflammasome and immune disorders
- Retinal Diseases and Treatments
- Cell Adhesion Molecules Research
- Botanical Research and Chemistry
- Pharmacological Effects of Natural Compounds
- Peptidase Inhibition and Analysis
- Probiotics and Fermented Foods
- Breast Cancer Treatment Studies
- Sulfur Compounds in Biology
- Inflammatory Biomarkers in Disease Prognosis
- Supramolecular Self-Assembly in Materials
- Flavonoids in Medical Research
- Chemokine receptors and signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Biochemical and Structural Characterization
- Thermoregulation and physiological responses
- MicroRNA in disease regulation
- Glutathione Transferases and Polymorphisms
- Cardiac and Coronary Surgery Techniques
- Advanced Glycation End Products research
China Tobacco
2025
Guiyang Medical University
2024-2025
Affiliated Hospital of Guizhou Medical University
2024-2025
Ningxia Medical University
2024
Southern Medical University Shenzhen Hospital
2023
First Affiliated Hospital of Guangdong Pharmaceutical University
2021-2022
The First Affiliated Hospital, Sun Yat-sen University
2006-2020
Sun Yat-sen University
2006-2020
University of Pittsburgh
2019
Stevens Institute of Technology
2012-2017
Atherosclerosis (AS) is a chronic inflammatory disease involving cell death and responses. Pyroptosis, newly discovered pro-inflammatory programmed process, exacerbates However, the roles of cathepsin B (CTSB) in pyroptosis AS remain unclear. To gain further insight, we fed ApoE -/- mice high-fat diet to investigate effects mechanisms CTSB overexpression silencing on AS. We also explored specific role vascular smooth muscle cells (VSMCs) vitro . The study revealed that led formation plaques,...
The biochemical and transcriptional regulatory mechanisms of chlorophyll metabolism have been extensively studied, but the translational remain poorly understood. In this study, we found that NtDHS1 deficiency in N. tabacum resulted smaller leaves increased leaf content. Protein content determination experiments revealed global protein synthesis Ntdhs1 mutant was decreased. A ribosome profiling sequence (Ribo-seq) assay showed translation level genes related to cell growth significantly...
Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis and thereby involved in the development progression solid tumours. Associations between three VEGF gene polymorphisms (-634 G/C, +936 C/T, +1612 G/A) breast cancer risk have been extensively studied, but currently available results are inconclusive. Our aim was to investigate associations Chinese Han patients. We performed hospital-based case-control study including 680 female incident patients age-matched...
Cigarette smoking increases susceptibility for microbial infection in respiratory system. However, the underlying molecular mechanism(s) is not fully elucidated. Here we report that cigarette extract (CSE) bacterial load lung epithelial cells via downregulation of ubiquitin-specific protease 25 (USP25)/histone deacetylase 11 (HDAC11) axis. CSE treatment decreases HDAC11 at protein level without significant changes its transcription. Concomitantly, accelerates a USP25 ubiquitination and...
Coronary artery disease (CAD) is characterized by insufficient vasculogenic response to ischemia, which typically accompanied dysfunction of endothelial outgrowth cells (EOCs). CXC chemokine receptor 7 (CXCR7) a key modulator the neovascularization EOCs perfusion defect area. However, mechanism underlying role in CAD-related abnormal vasculogenesis still not clear. Here, we investigated alteration EOCs-related capacity patients with CAD and its potential mechanism. Compared isolated from...
Sortase A catalyzed ligation of ultra-short peptides leads to inter/intra-molecular transpeptidation form either linear or cyclic oligomers dependent upon the peptide length. Cyclic were main products for with more than 15aa. However, (<15aa) peptides, became predominant in prolonged reactions. Peptides 1–3 aminoglycines equally active but from containing one aminoglycine prone hydrolysis.
Background Pulse wave velocity and flow-mediated vasodilation (FMD) are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse related to FMD in patients with coronary artery disease (CAD). Therefore, the present study was designed investigate alteration brachial-ankle (baPWV) endothelial function CAD patients. Methods Thirty-three thirty control subjects were recruited this study. baPWV measured non-invasively using a VP 1000 automated...
<title>Abstract</title> More and more studies have shown that sulfur metabolism plays an important role in various cancers, but not much research has been done on Liver Hepatocellular Carcinoma (LIHC). This study aimed to discovered genes with high correlation between LIHC. GSE148985, a dataset containing 10 experimental samples 5 control was used find differentially expressed (DEGs) metabolism; DEGs LIHC were found from The Cancer Genome Atlas(TCGA)database. Subsequently, 11 obtained,...
Various clinical practices prove that traditional Chinese medicines, integrated traditionalChinese and western medicines make enormous contributions to tumor treatment as well alleviation of chemotherapy side effect. Alkaloid, polysaccharide saponin are examples natural bioactive products can impede the progression tumors. Besides, researches on widely-used tradition anti-tumor medicine formulas indicate these agents induce apoptosis cells. Therefore, there is an extensive perspective in...
Abstract Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) provide added vascular protection beyond glucose lowering to patients with type diabetes mellitus (T2DM). Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism for diabetic complications. Yet, whether SGLT2i protect vessels in by improving the function of EPCs remains be elucidated. Methods: Sixty-three T2DM and 60 healthy participants were enrolled, 15 group took dapagliflozin 3 months....
Abstract Background : Sodium-glucose cotransporter 2 inhibitors (SGLT2i) provides added vascular protection beyond glucose lowering to patients with type diabetes mellitus (T2DM). Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism for diabetic complications. Yet, whether SGLT2i protect in by improving the function of EPCs remain be elucidated. Methods Sixty-three T2DM and 60 healthy participants were enrolled, 15 group taken dapagliflozin 3 months. Retinal...