A5028982370- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Neurological disorders and treatments
- Cardiac electrophysiology and arrhythmias
- Botulinum Toxin and Related Neurological Disorders
- Immune cells in cancer
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Research and Treatments
- Spinal Dysraphism and Malformations
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Ubiquitin and proteasome pathways
- Autoimmune and Inflammatory Disorders
- Spinal Cord Injury Research
- Neurogenetic and Muscular Disorders Research
- Gastric Cancer Management and Outcomes
- Glycosylation and Glycoproteins Research
Nanjing University of Chinese Medicine
2025
First Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Shaanxi Provincial People's Hospital
2015-2023
Shanxi Medical University
2008-2022
Shaanxi Provincial People's Hospital
2008-2022
Institute of Forensic Science
2022
Xi'an Jiaotong University
2015-2022
Xi’an Children’s Hospital
2022
University of Arkansas for Medical Sciences
2019-2020
INTRODUCTION: Duodenal epithelial barrier impairment and immune activation may play a role in the pathogenesis of functional dyspepsia (FD). This study was aimed to evaluate duodenal epithelium patients with FD healthy individuals for detectable microscopic structural abnormalities. METHODS: is prospective using esophagogastroduodenoscopy enhanced confocal laser endomicroscopy (CLE) mucosal biopsies (n = 16) controls 18). Blinded CLE images analysis evaluated density gaps (cell extrusion...
Tumor-associated carbohydrate antigens (TACAs) support cell survival that could be interrupted by anti-TACA antibodies. Among TACAs mediate signals are the neolactoseries antigen Lewis Y (LeY) and ganglioside GD2. To induce sustained immunity against both LeY GD2, we developed a mimicking peptide (CMP) as surrogate pan-immunogen mimics both. This CMP, referred to P10s, is N-terminal half of vaccine named P10s-PADRE, C-terminal which (PADRE) Pan-T-cell epitope. A Phase I dose-escalation trial...
Abstract Calcyclin-binding protein/Siah-1–interacting protein (CacyBP/SIP), a target of the S100 family, which includes S100A6, S100A1, S100A12, S100B, and S100P, has been identified as component novel ubiquitinylation complex leading to β-catenin degradation. However, function CacyBP/SIP in gastric cancer not elucidated. In present study, we prepared overexpressing knockdown cell lines cancer. Forced expression inhibited proliferation cells, suppressed tumorigenicity vitro, prolonged...
M2-type polarization of tumor associated-macrophage (TAM) is involved in the malignancy gastrointestinal stromal (GIST) progression. ETS variant 1 (ETV1) has been previously validated to regulate GIST pathogenesis. Our study intended explore role and mechanism ETV1 mediating M2-polarization TAM First, we analyzed correlation between expression tissues. IL-4 was used treat THP-1-derived cells IL-4-stimulated were co-cultured with GIST-T1 mimic microenvironment. A loss-of-function assay...
Abstract Peroxisome proliferator‐activated receptor γ coactivator 1α (PGC‐1α) is a transcriptional that has been characterized as master regulators of mitochondrial biogenesis. It reported aberrant regulation PGC‐1α involved in variety human cancers. However, whether the tumor growth and metastasis gastric cancer (GC) remains unknown. In present study, we found expression was upregulated GC tissues cell lines. Inhibition inhibited viability, migration, invasion, promoted apoptosis cells....
In traumatic brain injury, absent in melanoma 2 (AIM2) has been demonstrated to be involved pyroptotic neuronal cell death. Although the pathophysiological mechanism of spinal cord injury is similar that expression and cellular localization AIM2 after still not very clear. present study, we used a rat model T9 contusive produced using weight drop method. The rats were randomly divided into 1-hour, 6-hour, 1-day, 3-day 6-day (post-injury time points) groups. Sham-operated only received...
Abstract Objective Mucosal barrier dysfunction plays a crucial role in intestinal inflammation Crohn’s disease (CD). Intestinal epithelial cell (IEC) death resulting from innate immune activation, termed pyroptosis, was recently found to be cause of this defect. The aim study determine the predictive value pretreatment ileal biopsy pyroptosis as biomarker for clinical response vedolizumab CD. Design patients ranging 18 80 years old 5 IBD centers with pre-vedolizumab biopsies during...
Colorectal cancer (CRC) is the third most common and fourth leading cause of mortality, twin studies have shown that approximately 35% variation in susceptibility to CRC involves inherited genetic differences. We sought investigate potential associations between some single nucleotide polymorphisms (SNPs) risk Chinese Han population.We conducted a case-control study including 269 cases 309 controls. Sixteen SNPs associated with were selected from previous genome-wide association genotyped...
Previous studies by our group have demonstrated that the transplantation of exogenous platelet-derived growth factor (PDGF)-AA-overexpressing oligodendrocyte progenitor cells (OPCs) promotes tissue repair and recovery neurological function in a rat model spinal cord injury (SCI). However, it remains unclear whether treatment with PDGF-AA also affects endogenous oligodendrocytes (OL) or even neurons, thus promoting further functional after SCI. In present study, we evaluated therapeutic...
The previous studies showed that alternatively activated anti-inflammatory macrophage (M2) adoptive immunity can improve the proportion of local M2 cells and play neuroprotective effect after spinal cord injury (SCI). Its molecular mechanism is not yet very clear. Therefore, this study aims to analyze transfer on expression gene transcription. Sprague-Dawley (SD) rats were used for culture macrophages establishment SCI models. After SCI, polarized transferred injured by tail vein injection....
Abstract Ceruloplasmin (Cp), an enzyme containing six copper atoms, has important roles in iron homeostasis and antioxidant defense. After spinal cord injury (SCI), the cellular components local microenvironment are very complex include functional changes of resident cells infiltration leukocytes. It been confirmed that Cp is elevated primarily astrocytes to a lesser extent macrophages following SCI mice. However, its expression other cell types still not clear. In this manuscript, we...
Therapeutic efficacy of biologics has remained at about 50% for 2 decades. In Crohn's disease (CD) patients, we examined the predictive value an epithelial cell biomarker, ileal microvillar length (MVL), clinical response to ustekinumab (UST) and vedolizumab (VDZ) its relationship another intestinal (IEC) pyroptosis, with respect VDZ.Ileal biopsies from UNITI-2 randomized controlled trial were analyzed MVL as a predictor UST. 5-center academic retrospective cohort CD was determine VDZ....
Purpose. To examine the effects of fluid contamination on reverse torque value (RTV) abutment screws. 484 titanium fixtures were mounted into stainless-steel holders. Methods. 11 groups (44 specimens in each group) implants acrylic resin. Ten fixture screw holes contaminated with chlorhexidine, saliva, blood, fluoride, or combination groups, and one group served as a control without contamination. simulate oral environment, samples subjected to thermal cycling cyclic loading. Results. The...
Inhibitor of growth 1b (ING1b) is considered to be a class II tumor suppressor gene. Although decreased expression p33ING1b has previously been reported in colorectal cancer (CRC), its role CRC remained elucidated. The present study was designed assess the function and further evaluate underlying mechanisms action. Western blot analysis confirmed that ING1b gene significantly tissues compared with adjacent non-tumorous tissues. Furthermore, recombinant adenovirus-mediated ectopic resulted...
Background: Hypoxia-inducible factor 1α (HIF-1α) has been reported to be expressed aberrantly in gastric cancer cells. Stability and transactivation of HIF-1 were associated with the change intracellular calcium. We hypothesized that KCl depolarization may modulate activity cells through calcium involvement. Methods: HIF-1α expression its transcriptional determined SGC7901 treated and/or CoCl2 under normoxia. induced free concentration effect on was investigated subsequently. Results:...
Loss of function mutations in the human ether-a-go-go-related gene (hERG) cause long QT syndrome type 2 (LQT2). Most LQT2 patients are heterozygous mutation carriers which mutant hERG exerts potent dominant-negative effects. 1, 3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is known to enhance IKr WT-hERG. We investigated its actions following lipofectamine-induced expression both G604S- and WT-hERG heterologous HEK293 system. Cells transfected with pcDNA3-G604S-hERG did not lead...
Mutations in human ether-a-go-go-related gene (hERG) can lead to type 2 long-QT syndrome (LQT2). The authors previously identified the hERG mutation G604S results a loss of function and obviously decreased current amplitude impaired channel protein trafficking when co-expressed with WT-hERG. present study further investigates biological electrophysiological consequences pharmacologic chaperones HEK293 cells expressing G604S-hERG or co-expressing It was found that low temperature (27°C),...