A5101515333- Food composition and properties
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Circular RNAs in diseases
- Phytoestrogen effects and research
- Gut microbiota and health
- Proteins in Food Systems
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Neurological Disease Mechanisms and Treatments
- HIV/AIDS Research and Interventions
- RNA regulation and disease
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Phytase and its Applications
- HIV, Drug Use, Sexual Risk
- Protein Hydrolysis and Bioactive Peptides
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Nuclear Receptors and Signaling
- Insect symbiosis and bacterial influences
Anhui Medical University
2023-2025
Jilin Agricultural University
2021-2025
East China Normal University
2019-2024
Nanjing University
2020-2024
Changchun Institute of Biological Products
2021-2023
Beihang University
2023
Ningbo University
2022
Chinese Academy of Geological Sciences
2021
Bengbu Medical College
2018-2020
Dalian Medical University
2018-2020
Ribose 2′-O-methylation is involved in critical biological processes, but its functions and significance mRNAs remain underexplored. We have developed NJU-seq, a sensitive method for unbiased (Nm) profiling, Nm-VAQ, site-specific quantification tool. Using these tools tandem, we identified thousands of Nm sites on human mouse cell lines, which 68 84 selected were further validated to be more than 1% 2′-O-methylated. Unlike rRNA, most mRNA from 30% methylated. In addition, was dynamic,...
disease progression [10].
It is important to find specific and easily detectable diagnostic markers in acute stage of spinal cord injury for guiding treatment estimating prognosis. Although, microRNAs are attractive biomarkers, there still no uniform standard clinical evaluation based on “free circulation” miRNA spectrum. The reason may be that analysis from biological fluids influenced by many pre-analysis variables. Exosome miRNAs widely distributed body have advantages comparing with free miRNAs. the central...
After spinal cord injury (SCI), destructive immune cell subsets are dominant in the local microenvironment, which important mechanism of injury. Studies have shown that inflammasomes play an role inflammation following SCI, and apoptosis-associated speck-like protein containing a card (ASC) is adaptor shared by inflammasomes. Therefore, we speculated inhibiting ASC may improve microenvironment injured cord. Here, CRID3, blocker oligomerization, was used to study its effect on possible...
The potential benefits of insoluble dietary fiber (IDF) in the regulation lipid metabolism have been reported large prospective cohort studies although molecular regulatory mechanism is still unclear. Okara a by-product obtained during soybean processing for soy milk and curd (tofu), which rarely utilized can be cheap (DF) resource. In this study, structure physicochemical properties (SIDF) extracted from okara were characterized, prebiotic effects on fat investigated vivo. results showed...
In this study, a method for preparing low molecular weight peptides (HPH-VAP) from okara using high-pressure homogenization assisted double enzymes was proposed. order to explore its advantages, the effects of various methods on protein extraction rate and structure, antioxidant immune properties were compared. The results showed that increased by 69% 51% compared with other methods, structure only led changes in hydrogen bonds between peptide chains. HPH-VAP screened out through functional...
Glycine max is considered as an economically important grain crop with varied potential health merits in reducing chronic illnesses such cardiovascular diseases, obesity, immune disorders, etc. These biofunctional and health-promoting claims have been associated the soy bioactive phytochemicals, or secondary metabolites derived during processing digestion. That main component to enter systemic circulation reaching targeted organs. However, per our knowledge, only recently scientists started...
Insoluble dietary fiber (IDF) was recently revealed to have an antiobesity impact. However, the impact and potential mechanism of high-purity IDF derived from okara (HPSIDF) on obesity caused by a high-fat diet (HFD) remain unclear. Except for supplementation, intermittent fasting (IF) has attracted extensive interest as new strategy against obesity. Thus, we hypothesize that HPSIDF combined with IF treatment may be more effective in preventing In this study, synergistically alleviated...
The core reason for the nutritional richness and special flavour composition of traditional Chinese fermented soybean products lies in diversity microbial structures their metabolites, which include a variety potential probiotics. However, relatively little mainstream research has been conducted on these microorganisms, especially regions with unrelated product dietary habits, limiting high-value utilisation characteristic resources. In order to enhance efficient use functional exploitation...
Nitrite, a toxic substance, has been shown to adsorb and reduce organismal damage when natural adsorbents are used. Okara, due its unique structure adsorption properties, is one of the most eco-friendly efficient adsorbents, naturally reducing nitrite-induced biotoxicity without side effects. Consequently, six groups Kunming (KM) mice (n = 10) were comprehensively evaluated through tests for identifying physicochemical properties physiological indexes. Additionally, effects high-purity...
Introduction Emerging evidence has revealed that supplementation with insoluble dietary fiber (IDF) improves lipid metabolic disorders caused by a high-fat diet (HFD). Except for supplementation, intermittent fasting (IF) received widespread attention as new strategy against obesity. We hypothesized IDF combined IF treatment may synergistically alleviate HFD-induced imbalance. Methods This study integrated biochemical analysis hepatic lipidomics to explore biomarkers and potential mechanisms...
Abstract Muscular atrophy is among the systematic decline in organ functions aging, while defective thermogenic fat functionality precedes these anomalies. The potential crosstalk between adipose tissue and muscle during aging poorly understood. In this study, it showed that UCP1 knockout (KO) mice characterized deteriorated brown (BAT) function yet their glucose homeostasis sustained energy expenditure increased, possibly compensated by improved inguinal (iWAT) compared to age‐matched WT...
Hypoxia is crucial in the initiation and progression of tumor metastasis. Circular RNAs (CircRNAs) comprise a novel group non-coding, RNase R resistant regulatory which are generated by 'back-splicing' processes. However, characterization function circRNAs hypoxic cancer cells remain unknown.High throughput RNA-seq assay was performed lung adenocarcinoma (A549) under either normoxic or conditions. Bioinformatic analysis differentially expressed conducted their target genes were predicted...
Aging induces gradual accumulation of damages in cells and tissues, which leads to physiological dysfunctions.Aging-associated muscle dysfunction is commonly seen aged population severely affects their physical activity life quality, against aerobic training has been shown exert antagonizing or alleviating effects.Circular RNAs (circRNAs) play important roles various processes, yet involvement aging-associated not well understood.In this study, we performed comprehensive analysis circRNAs...
The present study aimed to investigate the effect of microRNA‑183 (miR‑183) on substantia nigra neurons by targeting oncostatin M receptor (OSMR) in a mouse model Parkinson's disease (PD). positive expression rates OSMR and apoptosis were detected immunohistochemistry terminal deoxynucleotidyl transferase‑mediated dUTP‑biotin nick end‑labeling, respectively. Substantia normal PD mice cultured vitro. association between miR‑183 was verified using dual luciferase reporter gene assay....