A5108447612- Dermatologic Treatments and Research
- Sphingolipid Metabolism and Signaling
- Genomics and Chromatin Dynamics
- Protein Structure and Dynamics
- Data Visualization and Analytics
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Hair Growth and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Gene expression and cancer classification
- Genomics and Rare Diseases
- Complex Network Analysis Techniques
- Genetic and rare skin diseases.
- Medical Image Segmentation Techniques
- PI3K/AKT/mTOR signaling in cancer
- Data Management and Algorithms
- Lipid metabolism and disorders
- Advanced Text Analysis Techniques
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Genetics, Bioinformatics, and Biomedical Research
- Drug Transport and Resistance Mechanisms
- Inflammasome and immune disorders
- melanin and skin pigmentation
University of Illinois Chicago
2007-2024
Peking University
2015-2024
Cincinnati Children's Hospital Medical Center
2024
Xuzhou Central Hospital
2024
Xuzhou Medical College
2024
Shanxi Medical University
2021
University of Technology Sydney
2016-2020
Guangdong Medical College
2008-2017
Virginia Commonwealth University
2010-2016
Tianjin University of Technology and Education
2014-2015
The potent lipid mediator sphingosine-1-phosphate (S1P) regulates diverse physiological processes by binding to 5 specific GPCRs, although it also has intracellular targets. Here, we demonstrate that S1P, produced in the mitochondria mainly sphingosine kinase 2 (SphK2), binds with high affinity and specificity prohibitin (PHB2), a highly conserved protein mitochondrial assembly function. In contrast, S1P did not bind closely related PHB1, which forms large, multimeric complexes PHB2. from...
Abstract Purpose: African Americans have higher incidence and poorer response to lung cancer treatment compared with Caucasians. However, the underlying molecular mechanisms for significant ethnic difference are not known. The present study examines differences in type frequency of MET proto-oncogene (MET) mutation correlated them other frequently mutated genes such as epidermal growth factor receptor (EGFR), KRAS2, TP53. Experimental Design: Using tumor tissue genomic DNA from 141 Asian, 76...
Bile acids are important hormones during the feed/fast cycle, allowing liver to coordinately regulate nutrient metabolism. How they accomplish this has not been fully elucidated. Conjugated bile activate both ERK1/2 and AKT signaling pathways via sphingosine 1-phosphate receptor 2 (S1PR2) in rodent hepatocytes vivo. Here, we report that feeding mice a high-fat diet, infusion of taurocholate into chronic fistula rat, or overexpression gene encoding S1PR2 mouse significantly upregulated...
Social media data with geotags can be used to track people's movements in their daily lives. By providing both rich text and movement information, visual analysis on social interesting challenging. In contrast traditional data, the sparseness irregularity of increase difficulty extracting patterns. To facilitate understanding movements, we present an interactive analytics system support exploration sparsely sampled trajectory from media. We propose a heuristic model reduce uncertainty caused...
The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it have been implicated in inflammatory bowel diseases mice humans; however, little is known about role of 2 S1P-specific phosphohydrolase isoforms, SGPP1 SGPP2, which catalyze dephosphorylation S1P to sphingosine. To elucidate their functions, we generated specific knockout mice. Deletion Sgpp2, mainly expressed gastrointestinal tract, significantly reduced dextran sodium sulfate (DSS)-induced colitis...
Abstract Calcyclin-binding protein/Siah-1–interacting protein (CacyBP/SIP), a target of the S100 family, which includes S100A6, S100A1, S100A12, S100B, and S100P, has been identified as component novel ubiquitinylation complex leading to β-catenin degradation. However, function CacyBP/SIP in gastric cancer not elucidated. In present study, we prepared overexpressing knockdown cell lines cancer. Forced expression inhibited proliferation cells, suppressed tumorigenicity vitro, prolonged...
Popular social media platforms could rapidly propagate vital information over networks among a significant number of people. In this work we present D-Map (Diffusion Map), novel visualization method to support exploration and analysis behaviors during such diffusion propagation on typical through map metaphor. D-Map, users who participated in reposting (i.e., resending message initially posted by others) one central user's posts series original tweets) are collected mapped hexagonal grid...
Significant events are often discussed and spread through social media, involving many people. Reposting activities opinions expressed in media offer good opportunities to understand the evolution of events. However, dynamics reposting diversity user comments pose challenges event-related data. We propose E-Map, a visual analytics approach that uses map-like visualization tools help multi-faceted analysis data on significant event in-depth understanding development event. E-Map transforms...
We propose BarcodeTree (BCT), a novel visualization technique for comparing topological structures and node attribute values of multiple trees. BCT can provide an overview one hundred shallow stable trees simultaneously, without aggregating individual nodes. Each is shown within single row using style similar to barcode, allowing be stacked vertically with matching nodes aligned horizontally ease comparison maintain space efficiency. design several visual cues interactive techniques help...
Replication and transcription activator (RTA), an immediate-early gene product of gamma-2 herpesviruses including Kaposi's sarcoma-associated herpesvirus (KSHV) murine gamma 68 (MHV-68), plays a critical role in controlling the viral life cycle. RTA acts as strong for several downstream genes KSHV MHV-68 through direct DNA binding, well via indirect mechanisms. HMGB1 (also called HMG-1) protein is highly conserved nonhistone chromatin with ability to bind bend DNA. promoted binding different...
ZNRD1, a transcription-associated gene, was recently found in our laboratory significantly suppress the cell proliferation of stomach cancer cells vitro and vivo. In this study, we firstly characterized ZNRD1 expression wide spectrum gastric diseases by immunohistochemistry RT-PCR. We also investigated its antiproliferative effects associated molecular alterations human line AGS mouse fibroblast NIH3T3. Anti-ZNRD1 monoclonal antibody H6 to react with 38 (63%) normal tissues, 51(81%)...
Gene expression involves transcription, translation, and mRNA protein degradation. Advanced RNA sequencing measures levels for cell state assessment, but level does not fully reflect level. Identifying heart proteomes their stress response is crucial. Using a cardiomyocyte-specific mouse model, we tracked synthesis after myocardial infarction. Our results showed that infarction suppresses unveils decoupling of translation transcription regulation in cardiomyocytes.
Abstract The identification of membrane-associated and secreted genes that are differentially expressed is a useful step in defining new targets for the diagnosis treatment cancer. Extracting information on subcellular localization represented DNA microarrays difficult limited by incomplete sequence annotation available existing databases. Here we combine biochemical bioinformatic approach to identify MCF-7 breast cancer cell line. Our based analysis differential hybridization levels RNAs...
Keloids are fibroproliferative dermal lesions characterized by the proliferation of fibroblasts and formation excess scar tissue, for which no effective treatment exists. We transfected a replication-incompetent adenovirus vector expressing green fluorescent protein interleukin-24 gene (Ad-GFP/IL-24) into keloid (KF) normal (NDF) in vitro to investigate suppression effects observation on cell lines growth, apoptosis, mitosis cycle, etc. The expression GFP IL-24 mRNA confirmed that...
Visualizing dynamic graphs are challenging due to the difficulty preserving a coherent mental map of changing graphs. In this paper, we propose novel layout algorithm which is capable maintaining overall structure sequence Through Laplacian constrained distance embedding, our method works online and maintains aesthetic individual shape similarity between adjacent in sequence. By same graph components across different time steps, can effectively help users track gain insights into changes....
Hierarchical structures are very common in the real world for recording all kinds of relational data generated our daily life and business procedures. A popular visualization method displaying such is called "Tree". So far, there a variety Tree methods that have been proposed most them can only visualize one hierarchical dataset at time. Hence, it raises difficulty comparison between two or more datasets.In this paper, we Pansy which used tree metaphor to merged hierarchies. We design unique...