A5103049435- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- T-cell and Retrovirus Studies
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Ubiquitin and proteasome pathways
- Vector-Borne Animal Diseases
- Click Chemistry and Applications
- Immune Cell Function and Interaction
- Nicotinic Acetylcholine Receptors Study
- Vagus Nerve Stimulation Research
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Biofield Effects and Biophysics
- Cancer Immunotherapy and Biomarkers
- Antioxidant Activity and Oxidative Stress
- Autophagy in Disease and Therapy
- HER2/EGFR in Cancer Research
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Psoriasis: Treatment and Pathogenesis
Howard Hughes Medical Institute
2021-2024
Harvard University
2021-2024
China Pharmaceutical University
2014-2024
Zhejiang Normal University
2013-2018
Xijing University
2018
Ludwig Cancer Research
2017
Shanxi Datong University
2017
WuXi AppTec (China)
2016
Center for Life Sciences
2014
Polycomb repressive complexes 1 and 2 (PRC1 2) are required for heritable repression of developmental genes. The cis- trans-acting factors that contribute to epigenetic inheritance mammalian not fully understood. Here, we show that, in human cells, ectopically induced silencing at initially active genes, but near ubiquitously expressed housekeeping is inherited many cell divisions. Unexpectedly, cells with mutations the H3K27me3 binding pocket Embryonic Ectoderm Development (EED) subunit...
Previous studies have demonstrated that oral administration of curcumin exhibited an anti-arthritic effect despite its poor bioavailability. The present study aimed to explore whether the gut-brain axis is involved in therapeutic curcumin.The collagen-induced arthritis (CIA) rat model was induced by immunization with emulsion collagen II and complete Freund's adjuvant. Sympathetic parasympathetic tones were measured electrocardiographic recordings. Unilateral cervical vagotomy (VGX)...
Human T-cell leukemia virus type 1 (HTLV-1) is the pathogen that causes adult (ATL), which a unique malignancy of CD4 + T cells. A role for long noncoding RNA (lncRNA) in HTLV-1-mediated cellular transformation has not been described. In this study, we demonstrated lncRNA ANRIL was important maintaining proliferation ATL cells vitro and vivo . shown to activate NF-κB signaling through forming ternary complex with EZH2 p65. Furthermore, epigenetic inactivation p21/CDKN1A involved oncogenic...
Abstract Interleukin-15 (IL-15) emerges as a promising immunotherapeutic candidate in oncology because of its pivotal role modulating both innate and adaptive immunity. However, the therapeutic utility remains concern due to unexpected toxicity. We propose here that mRNA lipid nanoparticle (mRNA-LNP) system can balance issue through targeted delivery increase IL-15 concentration tumor area reduce leakage into circulation. Utilizing Structure-driven TARgeting (STAR) platform, we acquired...
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus etiologically associated with adult (ATL). The HTLV-1 bZIP factor (HBZ), which encoded by minus strand of provirus, expressed in all ATL cases and supports the proliferation cells. However, precise mechanism growth promoting activity HBZ poorly understood. In this study, we showed that suppressed C/EBPα signaling activation induced either Tax or C/EBPα. As mechanisms HBZ-mediated inhibition, found physically interacted...
The rixosome and PRC1 silencing complexes are associated with deSUMOylating deubiquitinating enzymes, SENP3 USP7, respectively. How deSUMOylation deubiquitylation contribute to rixosome- Polycomb-mediated is not fully understood. Here, we show that the enzymatic activities of USP7 required for Polycomb target genes. deSUMOylates several subunits, this activity association PRC1. associates canonical (cPRC1) deubiquitinates chromodomain subunits CBX2 CBX4, inhibition USP results in disassembly...
ABSTRACT Adult T-cell leukemia (ATL) is a highly aggressive malignancy induced by human virus type 1 (HTLV-1) infection. Long noncoding RNA (lncRNA) plays critical role in the development and progression of multiple cancers. However, function lncRNA on HTLV-1-induced oncogenesis has not been elucidated. In present study, we show that expression ANRIL was elevated HTLV-1 infected cell lines clinical ATL samples. E2F1 transcription enhancing its promoter activity. Knocking down cells repressed...
Abstract While immune checkpoint therapies against CTLA-4, PD-1 and PD-L1 have achieved promising clinical outcome recently, the dynamic therapeutic responses spanning individual patients different cancer types warrant exploration validation of additional strategies. Since expression checkpoints in tumor infiltrating lymphocytes (TIL) has been interest to field, we attempted analyze several receptors on TILs samples. Unexpectedly, a number markers were subject time-dependent degradation...