Masato Eto
A5017340687- Neutrino Physics Research
- Innovations in Medical Education
- Astrophysics and Cosmic Phenomena
- Nitric Oxide and Endothelin Effects
- Particle physics theoretical and experimental studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Blood Pressure and Hypertension Studies
- Dark Matter and Cosmic Phenomena
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Patient-Provider Communication in Healthcare
- Global Health Workforce Issues
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Clinical Reasoning and Diagnostic Skills
- Nutrition and Health in Aging
- Empathy and Medical Education
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Menopause: Health Impacts and Treatments
- Cardiac Imaging and Diagnostics
The University of Tokyo
2016-2025
Okayama University of Science
2025
Teikyo University
2024
Tokyo Medical University
2023
University of Tokyo Hospital
1999-2021
Kyushu University
2016
University of Tsukuba
2012-2013
Tokyo Metropolitan Geriatric Hospital
2010
Hamamatsu University School of Medicine
2010
National Quarantine Station
2009
We present an analysis of atmospheric neutrino data from a 33.0 kton yr (535-day) exposure the Super-Kamiokande detector. The exhibit zenith angle dependent deficit muon neutrinos which is inconsistent with expectations based on calculations flux. Experimental biases and uncertainties in prediction fluxes cross sections are unable to explain our observation. consistent, however, two-flavor...
Solar neutrino measurements from 1258 days of data the Super-Kamiokande detector are presented. The based on recoil electrons in energy range 5.0--20.0 MeV. measured solar flux is $2.32\ifmmode\pm\else\textpm\fi{}0.03(\mathrm{stat}{)}_{\ensuremath{-}0.07}^{+0.08}(\mathrm{syst})\ifmmode\times\else\texttimes\fi{}{10}^{6}{\mathrm{cm}}^{\ensuremath{-}2}{\mathrm{s}}^{\ensuremath{-}1}$, which $45.1\ifmmode\pm\else\textpm\fi{}0.5(\mathrm{stat}{)}_{\ensuremath{-}1.4}^{+1.6}(\mathrm{syst})%$ that...
The first results of the solar neutrino flux measurement from Super-Kamiokande are presented. shown here obtained data taken between 31 May 1996, and 23 June 1997. Using our recoil electrons with energies above 6.5 MeV, we infer total ${}^{8}\mathrm{B}$ neutrinos to be $2.42\ifmmode\pm\else\textpm\fi{}0.06(\mathrm{stat}{)}_{\ensuremath{-}0.07}^{+0.10}(\mathrm{syst})\ifmmode\times\else\texttimes\fi{}{10}^{6}\mathrm{cm}{}^{\ensuremath{-}2}{\mathrm{s}}^{\ensuremath{-}1}$. This result is...
We report the result of a search for neutrino oscillations using precise measurements recoil electron energy spectrum and zenith angle variations solar flux from 1258 days neutrino-electron scattering data in Super-Kamiokande. The absence significant variation distortion places strong constraints on mixing mass difference flux-independent way. Using Super-Kamiokande measurement addition, two allowed regions at large are found.Received 19 March...
Background Estrogen has been reported to augment endothelium-dependent vasodilatation. The role of endogenous ovarian hormones in modulating vasodilatation, however, remains be determined. purpose the present study was investigate effects sex and menstrual cycle on flow-mediated Methods Results Seventeen female volunteers 25.1±0.8 years old 17 age-matched male were examined. We measured brachial artery diameters noninvasively using a 7.5-MHz ultrasound machine at rest, during reactive...
A total of 614 upward throughgoing muons minimum energy 1.6 GeV are observed by Super-Kamiokande during 537 detector live days. The measured muon flux is [1.74±0.07(stat)±0.02(sys)]×10−13cm−2s−1sr−1 compared to an expected [1.97±0.44(theor)]×10−13cm−2s−1sr−1. absolute in agreement with the prediction within errors. However, zenith-angle dependence does not agree no-oscillation predictions. distortion shape consistent νμ↔ντ oscillation hypothesis sin22θ>0.4 and 1×10−3<Δm2<1×10−1eV2 at 90%...
The flavor ratio of the atmospheric neutrino flux and its zenith angle dependence have been studied in multi-GeV energy range using an exposure 25.5 kiloton-years Super-Kamiokande detector. By comparing data to a detailed Monte Carlo simulation, (μ/e)DATA/(μ/e)MC was measured be 0.66±0.06(stat.)±0.08(sys.). In addition, strong distortion shape μ-like event distribution observed. number upward downward events found 0.52+0.07−0.06(stat.)±0.01(sys.), with expected value...
Background— Prostaglandins generated by cyclooxygenase (COX) have been implicated in hyperglycemia-induced endothelial dysfunction. However, the role of individual COX isoenzymes as well molecular mechanisms linking oxidative stress and dysfunction diabetes remains to be clarified. Methods Results— Human aortic cells were exposed normal (5.5 mmol/L) high (22.2 glucose. Glucose selectively increased mRNA protein expression COX-2. Its upregulation was associated with an increase thromboxane A...
A search for day-night variations in the solar neutrino flux resulting from oscillations has been carried out using 504 day sample of data obtained at Super-Kamiokande. The absence a significant variation set an absolute independent exclusion region two oscillation parameter space.
Background — Tissue factor plays a pivotal role in thrombus formation acute coronary syndromes. However, the regulatory mechanisms underlying tissue expression are poorly understood. Statins effective patients with Hence, aim of this study was to clarify human endothelial cells signaling pathways thrombin-induced and potential inhibitory effects statins. Methods Results In aortic cells, simvastatin prevented induction by thrombin (4 U/mL) concentration-dependent manner. The increase activity...
A measurement of the energy spectrum recoil electrons from solar neutrino scattering in Super-Kamiokande detector is presented. The results shown here were obtained 504 days data taken between 31 May 1996 and 25 March 1998. shape measured compared with expectation for ${}^{8}\mathrm{B}$ neutrinos. comparison takes into account both kinematic related effects process. spectral observation gives a ${\ensuremath{\chi}}^{2}$ 25.3 15 degrees freedom, corresponding to $4.6%$ confidence level.
Cilostazol, a selective inhibitor of PDE3, has protective effect on endothelium after ischemic vascular damage, through production nitric oxide (NO). The purpose the present study was to clarify molecular mechanisms underlying preventive treatment with cilostazol oxidative stress-induced premature senescence in human endothelial cells.Prematurely senescent umbilical vein cells (HUVECs) were induced by hydrogen peroxide (H(2)O(2)) as judged senescence-associated beta-galactosidase assay...
To investigate the predictors of falls, such as comorbidity and medication, in geriatric outpatients a longitudinal observational study.A total 172 (45 men 126 women, mean age 76.9 ± 7.0 years) were evaluated. Physical examination, clinical history medication profile obtained from each patient at baseline. These patients followed for up to 2 years falls self-reported their physicians. The factors associated with analyzed statistically.A 32 experienced within years. On univariate analysis,...
Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) have pleiotropic vascular protective effects besides cholesterol lowering. Recently, experimental and clinical studies indicated that senescence of endothelial cells is involved in dysfunction atherogenesis. Therefore, the present study was performed to determine whether statins would reduce clarify molecular mechanisms underlying antisenescent property statins.Senescent human umbilical vein were induced by hydrogen...
Vascular calcification is clinically important in the development of cardiovascular disease. It reported that hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) inhibited vascular several clinical trials. However, mechanism poorly understood. Recently, it has been suggested apoptosis one processes regulating smooth muscle cell (VSMC) calcification. In this study, we investigated effect statins on VSMC by testing their apoptosis, focusing particular regulation...
Objective— Arterial calcification is associated with cardiovascular disease as a complication of advanced atherosclerosis. Aged vascular cells manifest some morphological features senescent phenotype. Recent studies have demonstrated that mammalian sirtuin 1 (SIRT1), histone deacetylase, an exciting target for management. Here, we investigated the role SIRT1 in model smooth muscle (SMCs). Methods and Results— In adenine-induced renal failure rats hyperphosphatemia, massive was induced aortic...