A5044707863- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Nutrition and Health in Aging
- Gastrointestinal disorders and treatments
- Phagocytosis and Immune Regulation
- Metastasis and carcinoma case studies
- Lung Cancer Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Colorectal Cancer Surgical Treatments
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tumors and Oncological Cases
- Gallbladder and Bile Duct Disorders
- Erythrocyte Function and Pathophysiology
- Cell death mechanisms and regulation
- IgG4-Related and Inflammatory Diseases
- Pancreatic function and diabetes
Tohoku Medical and Pharmaceutical University Hospital
2017-2025
Kitakyushu Municipal Medical Center
2015-2024
Tohoku Medical and Pharmaceutical University
2017-2024
Tohoku University
1991-2020
American Gastroenterological Association
2019
Futaba (Japan)
2002-2016
Shionogi (Japan)
2001-2016
Tohoku University Hospital
2011-2016
Creative Research Enterprises (United States)
2016
Hokkaido University
2015
Vascular calcification is clinically important in the development of cardiovascular disease. It reported that hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) inhibited vascular several clinical trials. However, mechanism poorly understood. Recently, it has been suggested apoptosis one processes regulating smooth muscle cell (VSMC) calcification. In this study, we investigated effect statins on VSMC by testing their apoptosis, focusing particular regulation...
Nephropathy is one of the most common complications diabetes mellitus. Glomerular hypertrophy a hallmark in early phase nephropathy. The mechanism glomerular hypertrophy, however, remains incompletely understood. We have reported that Gas6 (growth arrest-specific gene 6) and its receptor, Axl, play key role development glomerulonephritis. Here we show important Gas6/Axl pathogenesis diabetic hypertrophy. In streptozotocin (STZ)-induced rats, mesangial an increase filtration rate (GFR)...
Abstract Mast cells may be classified into at least two phenotypically distinct populations: connective tissue-type mast (CTMC) and mucosal (MMC). in the peritoneal cavity of mice are typical CTMC, whereas mucosa stomach show morphologic characteristics MMC. We investigated whether CTMC change to A single cell WBB6F1-+/+ was identified under phase-contrast microscope, picked up with micromanipulator, injected wall genetically cell-deficient WBB6F1-W/Wv mice. The histochemical electron...
The recurrent laryngeal nerve lymph node is one of the most common metastatic sites in oesophageal cancer, and dissection this considered beneficial. Although risk complications from procedure, such as palsy, well known, few reports have detailed those risks a large number cases. Our study examined dissection, with special focus on palsy. Retrospectively collected data 661 patients, who underwent transthoracic oesophagectomy for were analysed. Recurrent palsy occurred 36% patients. Among...
Growth-arrest specific gene 6 (Gas6) is a vitamin K–dependent growth factor for mesangial and epithelial cells. To investigate whether Gas6 essential progressive glomerular injury, we constructed Gas6–/– mice examined the role of in accelerated nephrotoxic nephritis (NTN), model glomerulonephritis. We found less mortality proteinuria than wild-type following injection serum. Glomerular cell proliferation, sclerosis, crescent formation, deposition fibrin/fibrinogen glomeruli were also reduced...
Growth-arrest specific gene 6 (Gas6) is a vitamin K–dependent growth factor for mesangial and epithelial cells. To investigate whether Gas6 essential progressive glomerular injury, we constructed Gas6–/– mice examined the role of in accelerated nephrotoxic nephritis (NTN), model glomerulonephritis. We found less mortality proteinuria than wild-type following injection serum. Glomerular cell proliferation, sclerosis, crescent formation, deposition fibrin/fibrinogen glomeruli were also reduced...
Abstract. Because proliferation of mesangial cells is a hallmark glomerular diseases, understanding the regulatory mechanism important for treatment. Warfarin has long been used to treat although its effect on remained unknown. Therefore, this study was conducted examine whether warfarin can inhibit mouse cell by focusing Gas6, which shown be activated vitamin K-dependent γ-carboxylation. In cells, Gas6 and receptor Axl were expressed. addition, exogenous phosphorylated Axl, extracellular...
CD133 was recently reported to be a cancer stem cell marker and prognostic for several tumors. However, few studies have investigated expression in esophageal squamous carcinoma (ESCC). Therefore, we examined whether could serve as of ESCC the correlation between clinicopathological findings patients markers.We studied 86 who underwent curative surgery without neoadjuvant treatment at Tohoku University Hospital (Sendai, Japan) January 2000 December 2005. We analyzed tissue specimens by...
The prevalence of GB virus C/hepatitis G (GBV-C/HGV) infection among intravenous drug users (IVDUs), patients with liver diseases, and blood donors in Nanning, southern China was studied. GBV-C/HGV RNA detected by reverse transcription polymerase chain reaction primers derived from the 5'-untranslated region. 64 85 IVnDs, 20 80 persons disease, 1 50 donors. Among IVDUs, associated antibodies to hepatis C (HCV) hepatitis B surface antigen (HBsAg). Eleven nucleotide sequences were determined...
To investigate the importance of bacterial infection in formation free fatty acids found brown pigment gallstones, and phospholipase activity hepatic bile, with or without presence infection, were compared. The concentration bile [0.467 +/- 0.447 mg per ml (mean S.D.)] was significantly higher than when absent (0.073 0.041 ml; p less 0.01). However, there no significant difference composition present. Biliary determined by counting [14C] palmitic acid released from [14C]dipalmitoyl...
Survival and prognostic factors were analyzed in 315 patients with esophageal cancer undergoing thoracoscopic-assisted esophagectomy (TAE). The 5-year survival rate of 57.8% was satisfactory, indicating the oncological feasibility TAE. Perioperative outcomes affected overall whole cohort but not subgroup treated 2 endoscopic stages.To estimate (TAE) for to clarify impact perioperative after TAE.Favorable TAE versus open surgery have been demonstrated. However, data a large are limited, no...
The aim of this study was to investigate the influence patients' age on postoperative morbidities including pneumonia. We reviewed clinical records 211 patients with stages I – III gastric cancer undergoing curative distal gastrectomy (DG) or total (TG). Patients were classified into an elderly (≧80 y.o.) a control (< 80 group. compared patient characteristics (sex ratio, disease stage, degree lymph node dissection, number retrieved nodes, and type reconstruction) early outcomes (operation...