A5014732616- Pain Management and Treatment
- Pain Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neuroscience and Neuropharmacology Research
- Musculoskeletal pain and rehabilitation
- Neurogenetic and Muscular Disorders Research
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Botulinum Toxin and Related Neurological Disorders
- Ion channel regulation and function
- Myofascial pain diagnosis and treatment
- Neurological diseases and metabolism
- Pluripotent Stem Cells Research
- Laser Applications in Dentistry and Medicine
- Neurological disorders and treatments
- Nerve injury and regeneration
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Functional Brain Connectivity Studies
- Liver Disease Diagnosis and Treatment
- Migraine and Headache Studies
- Prion Diseases and Protein Misfolding
Drexel University
2011-2021
Mayo Clinic
2015
IRCCS Istituto Auxologico Italiano
2015
Johns Hopkins University
2015
University of Toledo
2015
Universidade Federal do Rio Grande do Sul
2015
Philadelphia University
2015
Mayo Clinic in Florida
2015
Novem (Netherlands)
2012
University of Udine
2011
Complex regional pain syndrome (CRPS) is a severe chronic condition that most often develops following trauma. The pathophysiology of CRPS not known but both clinical and experimental evidence demonstrate the important NMDA receptor glial activation in its induction maintenance. Ketamine potent clinically available safe antagonist has well established role treatment acute pain. This randomized double-blind placebo controlled trial was designed to evaluate effectiveness intravenous ketamine...
Summary Macrophage-derived exosomes attenuated complete Freund's adjuvant-induced thermal hyperalgesia in mice. Exosomal microRNA signature from patients with complex regional pain syndrome suggests a potential therapeutic and biomarker utility for exosomes. Exosomes, secreted microvesicles transporting microRNAs (miRNAs), mRNAs, proteins through bodily fluids, facilitate intercellular communication elicit immune responses. contents vary, depending on the source physiological conditions of...
Complex Regional Pain Syndrome (CRPS) Types I and II are characterized by various combinations of sensory, autonomic motor abnormalities. disproportionate to the severity duration inciting event is most devastating symptom. In animal studies, conditions resulting in exaggerated pain states demonstrate elevated pro-inflammatory cytokines. addition, cytokines have been shown induce or increase neuropathic inflammatory pain. Utilizing high sensitivity enzyme linked immunosorbent assay (ELISA),...
Objective Complex regional pain syndrome (CRPS) is a severe chronic condition characterized by sensory, autonomic, motor, and dystrophic signs symptoms. This study was undertaken to expand our current knowledge of the evolution CRPS symptoms with duration disease. Method retrospective, cross-sectional analysis using data extracted from patient questionnaire evaluate clinical characteristics at different time points disease progression. Data included associated It also initiating events,...
Aberrant expression of small noncoding RNAs called microRNAs (miRNAs) is a common feature several human diseases. The objective the study was to identify miRNA modulation in patients with complex regional pain syndrome (CRPS) chronic condition resulting from dysfunction central and/or peripheral nervous systems. Due multitude inciting pathologies, symptoms and treatment conditions, CRPS patient population very heterogeneous. Our goal differentially expressed miRNAs blood explore their...
Bone marrow stromal cells can be used as an alternative source of for neural transplantation and repair. Here, the efficacy genetically modified was examined in a rat model Parkinson disease. Rat (rMSCs) human (hMSCs) were engineered by transduction with retroviruses encoding tyrosine hydroxylase (TH) GTP cyclohydrolase I, enzyme necessary production tetrahydrobiopterin cofactor TH (BH4). Transduced synthesized 3,4-dihydroxyphenylalanine (L-DOPA) vitro maintained their multipotentiality...
Summary Complex regional pain syndrome (CRPS) is a chronic disorder. Although its pathophysiology not completely understood, neurogenic inflammation thought to play significant role. Microglia and astrocytes are activated following tissue injury or have been reported be both necessary sufficient for enhanced nociception. Blood-borne monocytes/macrophages can infiltrate the central nervous system (CNS) differentiate into microglia resulting in hypersensitivity pain. The primary aim of this...
Complex regional pain syndrome (CRPS) is a severe chronic condition that most often develops following trauma. Some investigators have postulated CRPS to be post-traumatic neuralgia associated with distal degeneration of small-diameter peripheral axons. Intravenous immunoglobulin treatment (IVIG) has been shown efficacious in the painful polyneuropathies. patients reported respond IVIG. Based on recent hypothesis proposing an autoimmune etiology for CRPS, we decided offer plasma exchange...
Extracellular RNA in circulation mediates intercellular communication normal and pathological processes. One mode of circulating miRNA transport bodily fluids is within 30-150 nm small extracellular vesicles (sEVs) or exosomes. Uptake sEVs can regulate gene expression recipient cells enabling miRNAs to exert paracrine systemic effects. Complex regional pain syndrome (CRPS) a debilitating disorder characterized by chronic inflammation. Our previous investigations identified significant...
Chronic regional pain syndrome (CRPS) is a severe condition that usually results from an injury or surgical procedure. The in CRPS often spreads the site of injury, and with time becomes refractory to conventional therapy. present study was undertaken evaluate effects 5-day continuous intravenous lidocaine treatment patients afflicted CRPS.Intravenous administered escalating dose schedule 49 severely affected monitored setting over 5 days. Evaluation parameters other signs symptoms were...