A5115603599- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Circular RNAs in diseases
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Urological Disorders and Treatments
- Hippo pathway signaling and YAP/TAZ
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Renal and related cancers
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
Kunming Medical University
2017-2025
First Affiliated Hospital of Kunming Medical University
2017-2025
Zhejiang Shuren University
2020-2024
Zhejiang University
2015-2024
Shandong Provincial Hospital
2022-2024
Shandong First Medical University
2022-2024
Air Force Medical University
2024
First Affiliated Hospital of Zhengzhou University
2021-2023
Zhengzhou University
2023
Guangzhou Medical University
2021
Multi-drug resistance is the major cause of chemotherapy failure in hepatocellular carcinoma (HCC). YAP, a critical effector Hippo pathway, has been shown to contribute progression, metastasis and invasion cancers. However, potential role YAP mediating drug remains obscure.RT-qPCR western blot were used assess expression HCC cell lines. CCK-8 assays, flow cytometry, xenograft tumour model, immunochemistry GFP-mRFP-LC3 fusion proteins utilized evaluate effect on multi-drug resistance,...
The decrease of microRNA-452 (miR-452) in gliomas promoted stem-like features and tumorigenesis. However, the role miR-452, especially regulating cancer stem cells (CSCs) hepatocellular carcinoma (HCC) remains ambiguous. We enriched HCC by serial passages hepatospheres with chemotherapeutic agents. Stem-like characteristics including capabilities chemo-resistance, stemness-related gene expression profiling, self-renewal, tumorigenicity metastasis formation were detected. MiR-452 was markedly...
Clinical outcomes for advanced malignant melanoma (MM) are often poor due to tumor invasiveness, metastasis, recurrence, and multidrug resistance.We investigated whether apoptosis, cell cycle regulation, oxidative status, redox balance were altered by changes in the expression of long noncoding RNA, growth arrest-specific transcript 5 (GAS5), MM cells.Analysis clinical samples from patients showed that rate reduced GAS5 expression, relative adjacent noncancerous tissues, was significantly...
Disulfidptosis is a recently discovered programmed cell death pathway. However, the exact molecular mechanism of disulfidptosis in cutaneous melanoma remains unclear.In this study, clustering analysis was performed using data from public databases to construct prognostic model, which subsequently externally validated. The biological functions model genes were then investigated through various experimental techniques, including qRT-PCR, Western blotting, CCK-8 assay, wound healing and...
Glucose-6-phosphate dehydrogenase (G6PD) participates in glucose metabolism and it acts as the rate-limiting enzyme of pentose phosphate pathway (PPP). Recently, G6PD dysregulation has been found a variety human cancers. Through analyzing published data The Cancer Genome Atlas (TCGA), our pilot study indicated that mRNA expression was significantly higher advanced Fuhrman grade clear cell renal carcinoma (ccRCC). These clues promoted us to further evaluate profile its prognostic impact...
// Qiao Zhang 1, * , Zhe Yang 2, Qiaoqiao Han Honggang Bai 1 Yanling Wang Xiaojia Yi 3 Zihan Lijuan Lu Jiang Xin Song 4 Yingmin Kuang 5 and Yuechun Zhu Department of Biochemistry Molecular Biology, School Basic Medical Sciences, Kunming University, Chenggong District, 650500, Yunnan Province, China 2 Pathology, The First Affiliated Hospital Wuhua 650032, Second 650101, Cancer Biotherapy Center, Third Xishan 650118, Organ Transplantation, These authors have contributed equally to this work...
Glucose‑6‑phosphate dehydrogenase (G6PD) is crucial rate‑limiting enzyme of the pentose phosphate pathway (PPP). G6PD dysregulation has been reported in various types human cancer, and role cancer progression was demonstrated numerous studies. A previous study from our laboratory described prognostic significance clear cell renal carcinoma (ccRCC), its proliferative through positive feedback regulation phosphorylated form signal transducer activator transcription 3. However, ccRCC invasion...
Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, is essential for the heart, motor neuron and pancreas development. Recently, ISL-1 has been found in some types of human cancers. However, how exerts role tumor development not clear. The expression was assessed 211 lymphoma samples 23 normal lymph node samples. Immunohistochemistry results demonstrated markedly higher 75% non-Hodgkin (NHL) compared with that nodes or Hodgkin (HL) CCK-8 analysis, cell cycle...
Interleukin-8 (IL-8) serves an important function in chronic inflammation and cancer development; however, the underlying molecular mechanism(s) of IL-8 uterine cervical remains unclear. The present study investigated whether its receptors [IL-8 receptor (IL-8R)A IL-8RB] contributed to proliferative migratory abilities HeLa cells, also potential mechanisms. Results demonstrated that were detected levels IL-8RA significantly increased compared with those IL-8RB. Furthermore, level tissues was...
Liver fibrosis is a serious threat to human health, and there currently no effective clinical drug for treatment of the disease. Although Galectin‑1 effective, its role in liver function, inflammation, matrix metalloproteinases activation hepatic stellate cells (HSCs) remains be elucidated. The aim present study was elucidate effect on activation, proliferation apoptosis HSCs mouse model fibrosis. Following successful establishment tissue collection, (mHSCs) were identified an mHSC line...
Abstract The regulatory relationship between silent information regulator 2 (SIRT2) and glucose 6‐phosphate dehydrogenase (G6PD) in clear cell renal carcinoma (ccRCC) is still unclear. present study aimed to explore the function of SIRT2 its effect on G6PD ccRCC. Cancer Genome Atlas data mining was first analyzed. Quantitative real‐time PCR western blot analyses were used assess mRNA protein expression levels, respectively. Cell viability, colony formation, cycle, apoptosis, TUNEL assays EdU...
The long noncoding RNA HOTTIP has recently been described as a biomarker of poor prognosis in patients with hepatocellular carcinoma (HCC).In the present study, we evaluated clinical significance expression predicting rate tumor recurrence HCC after liver transplantation (LT). We examined pattern and single nucleotide polymorphism (SNP) genotype samples from 155 underwent LT, its correlation parameters patient was analyzed. suppressed using siRNA to explore role plays progression.The level...
The genomic features of cancer cells may confer the metastatic ability lung adenocarcinoma (LUAD) to metastasize specific organs. We aimed identify differences in alterations between patients with primary LUAD and without metastases elucidate biology that help developing biomarker-directed therapies for advanced or disease. A retrospective cohort 497 including 388 tumors (PR), 53 bone (MT-bone), 30 liver (MT-liver), 26 brain (MT-brain) was tested by a next-generation sequencing assay. EGFR,...
Glucose 6-phosphate dehydrogenase (G6PD) serves key roles in cancer cell metabolic reprogramming, and has been reported to be involved certain carcinogenesis. Previous results from our laboratory demonstrated that overexpressed G6PD was a potential prognostic biomarker clear renal carcinoma (ccRCC), the most common subtype of kidney cancer. could stimulate ccRCC growth invasion through facilitating reactive oxygen species (ROS)-phosphorylated signal transducer activator transcription 3...
Clear cell renal carcinoma (ccRCC) is a metabolic disease with high metastasis rate and poor prognosis. Our previous studies demonstrate that glucose-6-phosphate dehydrogenase (G6PD), the first rate-limiting enzyme of pentose phosphate pathway, highly expressed in ccRCC predicts outcomes patients. The aims this study were to confirm oncogenic role G6PD unravels novel mechanisms involving Cyclin E1 MMP9 G6PD-mediated progression.
Although programmed death ligand 1 (PD-L1) inhibitor plus chemotherapy regimen is a promising strategy for malignant tumors, it can induce significant immune-related adverse events, such as pneumonitis. Here, we report the first case of lethal pneumonitis in an Asian patient receiving anti-PD-L1 treatment.
Islet-1 (ISL-1), a LIM-homeodomain transcription factor, has been recently found to be essential for promoting postnatal pancreatic islet proliferation. However, the detailed mechanism not yet elucidated. In present study, we investigated by which ISL-1 promotes β-cell proliferation through regulation of CyclinD1 in HIT-T15 and NIT-1 cells, as well rat mass. Our results provide evidence that adult activating cooperation with Set7/9 PDX-1 form an ISL-1/Set7/9/PDX-1 complex. This complex...