A5102799972- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Ion Transport and Channel Regulation
- Winter Sports Injuries and Performance
- Immunotherapy and Immune Responses
- Cardiovascular Effects of Exercise
- Chronic Kidney Disease and Diabetes
- Chemokine receptors and signaling
- Lignin and Wood Chemistry
- Muscle and Compartmental Disorders
- Cardiac electrophysiology and arrhythmias
- Electrolyte and hormonal disorders
- Connective tissue disorders research
- Galectins and Cancer Biology
- Coal Combustion and Slurry Processing
- Cytokine Signaling Pathways and Interactions
- TGF-β signaling in diseases
- Milk Quality and Mastitis in Dairy Cows
- Machine Learning in Bioinformatics
- Genomics, phytochemicals, and oxidative stress
- Renin-Angiotensin System Studies
- Kruppel-like factors research
- Medicinal Plant Pharmacodynamics Research
- Adenosine and Purinergic Signaling
- Nuts composition and effects
Jiamusi University
2006-2025
Harbin Medical University
2011-2016
New York Medical College
2013
Tsinghua University
2012
PLA Information Engineering University
2007
Northeast Forestry University
2001
Chronic hyperglycemia, a hallmark of diabetes, can trigger inflammatory responses in the kidney, leading to diabetic nephropathy (DN). Follistatin-like protein 1 (FSTL1) has emerged as potential therapeutic target various kidney diseases. This study investigated effect high glucose on FSTL1 expression and its role oxidative stress cellular transdifferentiation injury HK-2 human proximal tubule epithelial cells, model DN. We FSTL1's level cells exposed using Western blotting quantitative...
Abstract CXCL3 belongs to the CXC‐type chemokine family and is known play a multifaceted role in various human malignancies. While its clinical significance mechanisms of action uterine cervical cancer (UCC) remain unclear. This investigation demonstrated that UCC cell line HeLa expressed CXCL3, strong expression was detected tissues relative nontumor tissues. In addition, strongly correlated with CXCL5 vitro, cells overexpressing treated exogenous or conditioned medium from WPMY exhibited...
Renal fibrosis is the pathological hallmark of chronic kidney disease (CKD) and manifests as glomerulosclerosis tubulointerstitial fibrosis. Reactive oxygen species contribute significantly to renal inflammation fibrosis, but most research has focused on superoxide hydrogen peroxide (H2O2). The animal heme peroxidases myeloperoxidase (MPO), eosinophil peroxidase (EPX), peroxidasin (PXDN) uniquely metabolize H2O2 into highly reactive destructive hypohalous acids, such hypobromous hypochlorous...
Interleukin-8 (IL-8) serves an important function in chronic inflammation and cancer development; however, the underlying molecular mechanism(s) of IL-8 uterine cervical remains unclear. The present study investigated whether its receptors [IL-8 receptor (IL-8R)A IL-8RB] contributed to proliferative migratory abilities HeLa cells, also potential mechanisms. Results demonstrated that were detected levels IL-8RA significantly increased compared with those IL-8RB. Furthermore, level tissues was...
Diabetic nephropathy (DN) is one of the most severe complications that can occur in patients with diabetes, and without effective timely therapeutic intervention, gradually progress to renal failure. Previous studies have focused on investigating pathogenesis DN; however, role dual‑specificity phosphatase 6 (DUSP6) DN not completely understood. Therefore, present study aimed investigate DN. model mice were established expression levels DUSP6 kidney tissues high glucose (HG)‑induced murine...
Chloride channels in the basolateral membrane play a key role Cl absorption thick ascending limb (TAL). The patch-clamp experiments were performed to test whether angiotensin II (AngII) increases TAL by stimulating 10-pS channels. AngII (1-100 nmol/L) stimulated channel TAL, an effect that was blocked losartan (angiotension AT1 receptor [AT1R] antagonist) but not PD123319 AT2 [AT2R] antagonist). Inhibition of phospholipase C or protein kinase also abolished stimulatory on Moreover,...
We used the patch-clamp technique to examine effect of angiotensin II (ANG II) on basolateral K channels in thick ascending limb (TAL) rat kidney. Application ANG increased channel activity and current amplitude 50-pS channel. The stimulatory was completely abolished by losartan, an inhibitor type 1 receptor (AT R), but not PD123319, AT 2 R antagonist. Moreover, inhibition phospholipase C (PLC) protein kinase (PKC) also abrogated TAL. This suggests that induced activating PLC PKC pathways....
The aim of the current study was to investigate therapeutic effects and mechanism platycodin in liver complications type 2 diabetes. All rats were randomly divided into two groups: control group (normal diet) model (a high‑fat high‑sugar diet). injected with 2% streptozocin (25 mg/kg body weight) through tail vein following 4 weeks dieting. After a total 8 dieting, fasting blood glucose (FBG) function examined. diet continued successful rats, which four groups treated doses platycodins:...
China has rich lignite reserves which are the proper resources to be liquefied. As its low coalification degree, much hydrogen is wasted. Solvent extraction can save and improve liquefaction performance. The paper studies supercritical methanol treatment of with a device at high temperature pressure. Experiments mainly focus on effects temperature, pressure, catalysts pretreatment ways rate. Results indicate that rate increases raising pressure below 330 ℃,10 MPa. When exceeds ℃, decreases...
The aim of the present study was to investigate acute effect and mechanism tumor necrosis factor (TNF) on basolateral 50 pS K channels in thick ascending limb (TAL) rat kidney. TAL tubules were isolated from kidney, activity recorded using patch‑clamp technique. results indicated that application TNF (10 nM) significantly activated concentration‑dependent. Inhibition protein kinase A, phospholipase A2 tyrosine pathway inhibitors (H89, AACOCF3 Herbimycin respectively) did not abolish...
Adenosine is a molecule produced by several organs within the body, including kidneys, where it acts as an autoregulatory factor. It mediates ion transport in nephron segments, proximal tubule and thick ascending limb (TAL). Ion dictated part anionic chloride channels, which regulate crucial kidney functions, reabsorption of Na+ Cl‑, urine concentration, establishing maintaining corticomedullary osmotic gradient. The present study investigated effects adenosine on mRNA expression...
We used the patch‐clamp technique to study effect of stimulation Adenosine A 1 receptor on basolateral 50 pS K channels in thick ascending limb (TAL) rat kidney. 100nM or 200nM (ADO) inhibited channels. However, 400nM, 800nM and 1μM did not decrease channel activity. Adenosine's was mimicked by specific adenosine agonist Cyclohexyladenosine (CHA). Inhibition with 8‐cyclopentyl‐1, 3‐dipropylxanthine (DPCPX), antagonist, abolished inhibitory adenosine. Stimulation activity presence inhibitor...
Due to the complexity of insulin in life activities, role mammalian lactation has not been well explained. To investigate influence on milk fat synthesis, bovine mammary epithelial cells (BMECs) were cultured treatment with insulin. We determined content Triglyceride (TG) cell-free culture medium and found a notable increase TG secrection. Lipid droplet staining study showed consistent result. also used real-time quantitative PCR western blotting detect expression signaling molecules related...