A5101752179- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Inflammation biomarkers and pathways
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Autophagy in Disease and Therapy
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
- Advanced Thermoelectric Materials and Devices
- Nosocomial Infections in ICU
- Trauma and Emergency Care Studies
- Glioma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Electrolyte and hormonal disorders
- Cardiac Fibrosis and Remodeling
- Congenital Heart Disease Studies
- Crystallization and Solubility Studies
- Immune Response and Inflammation
- Hematological disorders and diagnostics
- Thermal properties of materials
- Cannabis and Cannabinoid Research
- X-ray Diffraction in Crystallography
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Qingdao University
2024
Yuhuangding Hospital
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2022
Sun Yat-sen University
2018-2022
Chongqing Medical University
2022
Biogen (United States)
2016-2021
Dalian Medical University
2020
Creative Commons
2019
Abstract Thermoelectric materials have potential applications in energy harvesting and electronic cooling devices, bismuth antimony telluride (BiSbTe) alloys are the state‐of‐the‐art thermoelectric that been widely used for several decades. It is demonstrated mixing SiC nanoparticles into BiSbTe matrix effectively enhances its properties; a high dimensionless figure of merit ( ZT ) value up to 1.33 at 373 K obtained Bi 0.3 Sb 1.7 Te 3 incorporated with only 0.4 vol% nanoparticles....
The aim of this study is to determine the mechanism sepsis‐induced vascular hyperpermeability and beneficial effect glucocorticoid in protecting endothelium. Male Sprague‐Dawley rats were given either a bolus intraperitoneal injection nonlethal dose LPS ( Escherichia coli 055:B5, 10 mg/kg, Sigma) or vehicle (pyrogen‐free water). Animals treatment groups also dexamethasone (4 30 min prior injection) matrix metalloproteinases (MMPs) inhibitor doxycycline after injection). Both activities...
Septic cardiomyopathy is one of the most serious complications sepsis or septic shock. Basic and clinical research has studied mechanism cardiac dysfunction for more than five decades. It become clear that myocardial depression not related to hypoperfusion. As heart highly dependent on abundant adenosine triphosphate (ATP) levels maintain its contraction diastolic function, impaired mitochondrial function lethally detrimental heart. Research shown mitochondria play an important role in organ...
<h3>Objective:</h3> To study the attributes of quantitative strength testing using hand-held dynamometry (HHD) as an efficacy measure in 2 large phase 3 amyotrophic lateral sclerosis (ALS) trials. <h3>Methods:</h3> In trials ceftriaxone and dexpramipexole, 513 943 patients, respectively, were enrolled double-blind, randomized, placebo-controlled with planned follow-up at least 1 year. Patients studied every months dexpramipexole study. Evaluators HHD trained had to show evidence adequate...
Setting lactate kinetics at >30% might improve the clinical outcomes of patients with sepsis-associated hyperlactatemia. The aim this study was to explore outcome benefits stepwise vs central venous oxygen saturation (ScvO2)-oriented hemodynamic therapy 6 h as protocol goal during early resuscitation. relevant parameters and adverse events after different targets in 360 randomly assigned hyperlactatemia were recorded compared. Heart rate (HR) 48 ScvO2 group higher than (105 ± 19 bpm 99 20...
Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and energy depletion play major role in during sepsis, mechanistic target of rapamycin (mTOR) as master sensor status mediator; however, there are little data describing its sepsis the heart.Cecal ligation puncture (CLP) or sham operation (SHAM) was performed rats. After treatment, pathological changes were determined by H&E staining, cardiac functions echocardiography,...
Mitochondrial dysfunction plays an important role in the development of septic cardiomyopathy. This study aimed to reveal protective uncoupling protein 2 (UCP2) mitochondria through AMP-activated kinase (AMPK) on autophagy during cardiomyopathy.UCP2 knockout mice via a cecal ligation and puncture (CLP) model H9C2 cardiomyocyte cell line response lipopolysaccharide (LPS) vitro were used effect. The myocardial morphological alterations, indicators mitochondrial injury levels...
Abstract Normal-appearing white matter is far from normal in multiple sclerosis; little known about the precise pathology or spatial pattern of this alteration and its relation to subsequent lesion formation. This study was undertaken evaluate normal-appearing abnormalities brain areas where sclerosis lesions subsequently form, investigate distribution persons with sclerosis. Brain MRIs pre-lesion were analysed participants new T2 lesions, pooled three clinical trials: SYNERGY (NCT01864148;...
Abstract The temperature dependence of the Raman spectra Bi 2 Te 3 and 0.5 Sb 1.5 thermoelectric films was investigated. coefficients E g (2) peak positions were determined as –0.0137 cm –1 /°C –0.0156 /°C, respectively. thermal expansion crystal caused a linear shift induced by change. Based on relation, reliable noninvasive micro‐Raman scattering method shown to measure conductivity films. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Measurement of general microcirculation remains difficult in septic shock patients. The peripheral perfusion index (PI) and sublingual monitoring are thought to be possible methods. This study was performed determine whether assessing by PI a new parameter, proportion vessel change rate (△PPV) from monitoring, can associated with patients' outcome.A prospective observational carried out, including 74 patients mixed intensive care unit. Systemic hemodynamic variables were obtained at T0 6 h...
It has recently been recognized that serum vimentin is elevated in infectious diseases, and plays a role regulating neutrophils macrophages associated inflammation. However, the mechanisms are unclear. This study was designed to explore of monocyte survival or apoptosis as well inflammatory cytokine secretion response lipopolysaccharides (LPSs).A human monocytic leukemia cell line (THP-1) transfected with vimentin-specific small interfering RNA (siRNA) over-expressing plasmid. Apoptosis...
Effective implementation of the Surviving Sepsis Campaign (SSC) guidelines has effectively reduced sepsis mortality. The effects hospital level and ownership on compliance with SSC guideline 1-hour bundle (Cssc-1h) are unclear. We designed this study to identify differences in Cssc-1h between secondary tertiary hospitals, public private hospitals.In survey, 1,420 hospitals were enrolled, including 864 482 34 40 hospitals. data collected January 1, 2018, December 31, 2018. outcomes adherence...