A5100433793- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Spondyloarthritis Studies and Treatments
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Genital Health and Disease
- MicroRNA in disease regulation
- Neurofibromatosis and Schwannoma Cases
- Mesenchymal stem cell research
- Oral and Maxillofacial Pathology
- Soft tissue tumors and treatment
- Musculoskeletal synovial abnormalities and treatments
- Bone and Dental Protein Studies
- Tumors and Oncological Cases
- Vascular Tumors and Angiosarcomas
- Rheumatoid Arthritis Research and Therapies
- Natural product bioactivities and synthesis
- Kruppel-like factors research
- RNA modifications and cancer
- Infrared Thermography in Medicine
- Photoacoustic and Ultrasonic Imaging
- dental development and anomalies
- Psoriasis: Treatment and Pathogenesis
Shengli Oilfield Central Hospital
2018-2022
Fuyang Second People's Hospital
2022
Cancer Institute (WIA)
2022
Shanghai Cancer Institute
2022
Shanghai Medical College of Fudan University
2022
Fudan University Shanghai Cancer Center
2022
Ningbo College of Health Sciences
2022
Memorial Sloan Kettering Cancer Center
2013-2020
Glomus tumors (GT) have been classified among of perivascular smooth muscle differentiation, together with myopericytoma, myofibroma/tosis, and angioleiomyoma, based on their morphologic overlap. However, no molecular studies carried out to date investigate genetic phenotype confirm shared pathogenesis. RNA sequencing was performed in three index cases (GT1, malignant GT; GT2, benign GT M1, multifocal myopericytoma), followed by FusionSeq data analysis, a modular computational tool developed...
Cellular myofibroblastic tumors other than desmoid-type fibromatosis are often diagnostically challenging due to their relative rarity, lack of known genetic abnormalities, and expression muscle markers which may be confused with sarcomas myogenic differentiation. In this study we investigate the molecular alterations a group cellular lesions in myofibroma myopericytoma spectrum for better subclassification. Two index cases were studied by paired-end RNA sequencing potential fusion gene...
Abstract Gene fusions resulting in oncogenic activation of various receptor tyrosine kinases, including NTRK1‐3, ALK, and RET, have been increasingly recognized soft tissue tumors (STTs), displaying a wide morphologic spectrum therefore diagnostically challenging. A subset STT with NTRK1 rearrangements were recently defined as lipofibromatosis‐like neural (LPFNTs), being characterized by mildly atypical spindle cells highly infiltrative growth the subcutis expression S100 CD34 immunostains....
Abstract Folic acid, served as dietary supplement, is closely linked to one-carbon metabolism and methionine metabolism. Previous clinical evidence indicated that folic acid supplementation displays dual effect on cancer development, promoting or suppressing tumor formation progression. However, the underlying mechanism remains be uncovered. Here, we report high-folate diet significantly promotes development in mice with hepatocellular carcinoma (HCC) induced by DEN/high-fat (HFD),...
Synovial chondromatosis (SC) is a rare benign cartilaginous neoplasm in which recurrent fibronectin 1 (FN1) and activin receptor 2A (ACVR2A) gene rearrangements have been recently reported. Triggered by case of malignant transformation SC (synovial chondrosarcoma) showing novel KMT2A-BCOR fusion targeted RNA sequencing, we sought to evaluate the molecular abnormalities cohort 27 cases using combined methodology fluorescence situ hybridization (FISH) and/or sequencing. Results showed that FN1...
BCOR immunoreactivity is a sensitive and highly specific marker for clear cell sarcoma of the kidney (CCSK). However, subset adult renal sarcomas which overexpress are negative genetic alterations, including gene fusions or BCOR-internal tandem duplication, thus remain unclassified. We report 5 such undifferentiated renal/perirenal raised differential diagnosis CCSK due to their morphologic appearance strong immunoreactivity, but on RNA sequencing proved be malignant solitary fibrous tumors...
Interleukin-1 (IL-1) is known to be involved in cartilage degeneration following joint injury or due osteoarthritis. In the present study, we explored effects of miR-150 on IL-1-stimulated human chondrogenic cells ATDC5.ATDC5 were transfected with mimic, inhibitor negative controls specific for miR-150, and subsequently treated by IL-1. CCK8 assay, PI FITC-conjugated Annexin V double-staining, Western blot, qRT-PCR ELISA assay performed determine changes cell viability, apoptosis, release...
Ankylosing spondylitis (AS) is a high disability and greatly destructive disease. In this study, we preliminarily studied the function mechanism of bilobalide (BIL) on interleukin (IL)-17-induced inflammatory injury in ATDC5 cells. CCK-8 migration assays were used to detect functions IL-7, BIL, microRNA (miR)-125a cell viability migration. The miR-125a level was changed by transfection, tested real-time quantitative polymerase chain reaction. Additionally, Western blot levels factors (IL-6...
We aimed to evaluate the regulatory effects of miR-148a-3p on stem cell osteogenic differentiation and enamel development by targeting runt-related transcription factor 2 (RUNX2) E-cadherin, respectively. TargetScan software was utilized predict binding sites between marker gene RUNX2 or E-cadherin. The changes in expression during epidermal cells were detected. After transfection with mimics inhibitor, induced towards differentiation, measured. regulated determined. liposome-mediated...