A5100373845- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- DNA and Nucleic Acid Chemistry
- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Molecular Sensors and Ion Detection
- Multiple Myeloma Research and Treatments
- Caching and Content Delivery
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Advanced Photocatalysis Techniques
- Ginseng Biological Effects and Applications
- Electrochemical sensors and biosensors
- Endoplasmic Reticulum Stress and Disease
- Sulfur Compounds in Biology
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Luminescence and Fluorescent Materials
- Molecular Biology Techniques and Applications
- Ammonia Synthesis and Nitrogen Reduction
- Metabolomics and Mass Spectrometry Studies
- Molecular Junctions and Nanostructures
- Traditional Chinese Medicine Analysis
Nanjing University
2023-2025
Nanjing General Hospital of Nanjing Military Command
2023-2025
Harbin Medical University
2012-2025
Johns Hopkins University
2025
University of Jinan
2022-2024
South China University of Technology
2023-2024
Cell Technology (China)
2023-2024
Shandong First Medical University
2024
Shandong Provincial Hospital
2024
Heilongjiang University of Chinese Medicine
2023
Molecular signaling in the tumor microenvironment (TME) is complex, and crosstalk among various cell compartments supporting metastasis remains poorly understood. In particular, role of vascular pericytes, a critical cellular component TME, cancer invasion warrants further investigation. Here, we report that an elevation FGF-2 samples from patients with nasopharyngeal carcinoma (NPC) xenograft mouse models promoted NPC metastasis. Mechanistically, cell-derived strongly pericyte proliferation...
As an effective ECL emitter, tetraphenylethene (TPE)-based molecules have recently been reported with aggregation-induced electrochemiluminescence (AIECL) property, while it is still a big challenge to control its aggregation states and obtain uniform aggregates intense emission. In this study, we develop three TPE derivatives carrying pyridinium group, alkyl chain, quaternary ammonium group via the Menschutkin reaction. The resulting exhibit significantly red-shifted FL enhanced emissions...
The unfolded protein response (UPR) signal in tumor cells activates UPR signaling neighboring macrophages, which leads to tumor‐promoting inflammation by up‐regulating target genes and proinflammatory cytokines. However, the molecular basis of this endoplasmic reticulum (ER) stress transmission remains largely unclear. Here, we identified secreted form Golgi 73 (GP73), a Golgi‐associated functional critical for hepatocellular carcinoma (HCC) growth metastasis, is indispensable ER...
OBJECTIVE: microRNAs (miRNAs) plays an important role in tumor development and progression act as oncogenes or suppressor genes the carcinogenesis process. miRNA is stable serum, recent studies have demonstrated feasibility of
Both vitamin B6 deficiency and B12 can present with symptoms that appear like polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS) syndrome, painful peripheral neuropathy sensorimotor dysfunction. There are rare reports of an association between POEMS even rarer syndrome. To our knowledge, this is the first described case deficiencies in both A man his 40s presented fatigue, imbalance, numbness tingling. Initial evaluation revealed low level, he received oral IV...
Abstract STING, functioning as an adaptor protein, plays a pivotal role in the induction of type I interferons (IFN) and pro-inflammatory cytokines subsequent to detection cytosolic DNA. The development non-nucleotide STING agonist amenable oral administration holds promise expanding clinical utility agonists among cancer patients. Leveraging computer-aided drug design strategies, cohort endowed with antitumor activities was meticulously designed synthesized, overarching goal exploring...
Abstract Background In the present work, we investigated effects of aqueous extract Maca (AEM) on energy metabolism and immunoregulation in spleen-deficient mice. Method We established a cyclophosphamide-induced spleen-deficiency model with ginseng, herb that strengthens splenic function, as control. Sixty male Kunming mice were randomly divided among 5 groups: normal, model, ginseng control (1.5 g/kg), AEM high dose low (0.75 g/kg). All animals, except those normal group, injected...
Mitochondrial oxidative phosphorylation defects are a common cause of mitochondrial diseases, which characterized by multiorgan involvement and clinically heterogeneous manifestations. Diagnosis is difficult because the lack feasible methods. In this study, complex I-V enzyme activity was measured in 64 patients with suspected disease 200 healthy controls. Spectrophotometric assay used for analysis peripheral leukocytes. based on clinical presentation, magnetic resonance imaging (MRI),...
We present an elegant approach to make a magnetic nanoparticle (MNP) conjugated DNA-sphere (MNP/DNA-SP) which is integrated with disulfide (MNP/DS-SP) or aptamer (MNP/sgc8-SP) for GSH detection, selective cancer cell recognition, effective drug delivery, and bioimaging.
Abstract We have quantitatively investigated the precipitation of DNA in different valence cations and various ethanol concentration solution. In free condition, monovalent ion cannot induce condensation turn to precipitation. Divalent can cause as concentrations both Mg 2+ (MgCl 2 ) Ca (CaCl go up a critical value about 50 mM. After adding ethanol, divalent promote significantly, but it has no effect on process by trivalent ions. solution 100 mM, volume ratio is 52% for However, decreases...
We report an SERS-based method for dynamic monitoring of minimal residual disease markers with high sensitivity clinical applications.
Introduction. Wnt7a is a secreted glycoprotein that regulates normal cellular proliferation and differentiation as well tumorigenesis progression. However, less understood about the role of in human endometrial carcinoma. The aim this study to investigate expression prognostic significance Methods. was immunohistochemically examined 35 endometrium, 33 hyperplastic endometrium 70 carcinomas. Results. lower carcinomas compared with (P < 0.001). inversely correlated FIGO stage = 0.001), grade...
Abstract Zn‐based catalytic batteries, recognized as eco‐friendly alternatives, are attracting significant research interest for their applications in energy storage, conversion, pollutant degradation, and ammonia synthesis. This review compiles the latest developments Zn‐nitrogen oxides (NO x ) covering various types including Zn‐nitrate, Zn‐nitric oxide, Zn‐nitrite batteries. study explores electrode reactions structural evolutions of these emphasizing different challenges posed by...