A5103021835- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Gene expression and cancer classification
- Advanced Nanomaterials in Catalysis
- Renal Diseases and Glomerulopathies
- Nanoplatforms for cancer theranostics
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- MicroRNA in disease regulation
- X-ray Diffraction in Crystallography
- Acne and Rosacea Treatments and Effects
- Renal cell carcinoma treatment
- Thyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- melanin and skin pigmentation
- Crystallization and Solubility Studies
- Ferroptosis and cancer prognosis
- Biomarkers in Disease Mechanisms
- Bee Products Chemical Analysis
- Graphene and Nanomaterials Applications
- Advanced Photocatalysis Techniques
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Restless Legs Syndrome Research
Qingdao University
2018-2024
Affiliated Hospital of Qingdao University
2018-2024
China University of Petroleum, Beijing
2024
82th Hospital of Pla
2021
Renal tubular epithelial cell (RTEC) death and renal interstitial inflammation are the most crucial pathophysiological changes in acute kidney ischemia/reperfusion injury (IRI). The microRNA (miR)-181d family plays diverse roles proliferation, apoptosis inflammation, but its target potential role IRI unknown. Here, we showed that expression of miR-181d-5p decreased a (HK-2) model hypoxia/reoxygenation (H/R) mouse IRI. Mechanistically, KLF6 was predicted as new gene through bioinformatic...
Clear cell renal carcinoma (ccRCC) is a serious and tenacious disease. Photodynamic therapy (PDT) photothermal (PTT) are effective means of cancer treatment. However, PDT combined with PTT has been rarely reported in ccRCC In the present study, by developing core-shell structured TiO2 @red phosphorus nanorods (TiO2 @RP NRs) as photosensitizer, feasibility effectiveness synchronous treatments for demonstrated. The NRs synthesized to drive ccRCC, which RP shell sensitizer even near-infrared...
Considerable evidences have indicated that elevated uric acid (UA) was involved in renal tubular injury leading to hyperuricemic nephropathy (HN). Scutellarin is a biologically active flavonoid derived from the Chinese traditional herb Erigeron breviscapus Hand-Mazz, which has been widely used treatment of cardiovascular and cerebrovascular diseases. In present study, we analyzed effect scutellarin on HN, by using C57BL/6 mice human epithelial cell line HK-2 subjected adenine/potassium...
Background: Acute kidney injury (AKI) is a common syndrome impacting about 13.3 million patients per year. Tilianin has been reported to alleviate myocardial ischemia/reperfusion (I/R) injury, while its effect on AKI unknown; thus, this study aimed explore if tilianin protects I/R-induced and the underlying mechanisms. Methods: The microarray dataset GSE52004 was downloaded from GEO DataSets (Gene Expression Omnibus). Differential expression analysis gene-set enrichment (GSEA) were performed...
Abstract STING, functioning as an adaptor protein, plays a pivotal role in the induction of type I interferons (IFN) and pro-inflammatory cytokines subsequent to detection cytosolic DNA. The development non-nucleotide STING agonist amenable oral administration holds promise expanding clinical utility agonists among cancer patients. Leveraging computer-aided drug design strategies, cohort endowed with antitumor activities was meticulously designed synthesized, overarching goal exploring...
Abstract Introduction Nicotiflorin is the main characteristic component of Nymphaea candida, which a natural product that reportedly ameliorates acute injury liver and cerebral cortex, but effect nicotiflorin on kidney (AKI) remains unknown. This study aimed to investigate effects ischaemia/reperfusion (I/R) AKI associated mechanisms. Methods We performed both (a) in vivo experiments with C57BL/6 mice bilateral renal pedicles clamped for 45 minutes (b) vitro human epithelial cells (HK‐2)...
Acute kidney injury (AKI) results in high morbidity and mortality among inpatients, while effective treatment intervention are still absent. Therefore, this study aims to explore the effects of Scutellarin (Scu) experimental models vivo vitro.In experiment, we employed a total 30 Wistar rats, which further were modelled by bilateral renal pedicle clip for 45 min, then received 50 mg/kg/day Scu. In vitro, HK-2 cells administered with 20μΜ Scu incubated hypoxia/reoxygenation (H/R) conditions...
Abstract Nanostructured heterojunctions offer a promising solution to overcome the limitations of narrow absorption spectra, limited penetration depths, and potential harm healthy cells in phototherapy for clear cell renal carcinoma (ccRCC) treatment with nanomaterials. In this study, heterostructure (PCN@HP) by decorating Hittorf's phosphorus nanorods onto biocompatible polymeric carbon nitride (PCN), enabling excitation NIR light is designed. Compared PCN HP alone, synthesized generated...
One-dimensional (1D) nanomaterials are widely used in different fields, and the increased application of 1D has drawn concerns about their unknown toxicity. titanium oxide (TiO2) crystal phases commonly applied environmental remediation solar energy conversion but these materials pose a threat to human health, especially kidneys, an organ with abundant blood flow. To systematically evaluate cytotoxicity TiO2 nanofibers TiO2(B), anatase, rutile phases, as well nanorods anatase were...
Abstract Thyroid dysgenesis (TD) accounts for most cases of congenital hypothyroidism. Although mutations in thyroid hormone receptor β ( THRB ) have been identified TD, the mutational spectrum and phenotype‐genotype correlations not fully elucidated. In this study, we aimed to find , examine functions these mutations, attempt elucidate relationship between TD. Thus, screened exons 280 patients with TD 200 normal subjects samples collected from China. We performed cell morphology assays, MTT...
Ischemia/reperfusion injury (IRI), a participant in acute kidney (AKI), can occur as series of pathological processes such inflammation. Linarin (LIN) has been widely used for different diseases. To confirm the anti-inflammatory value and relevant mechanism LIN during IRI, vivo vitro models were established. or dissolvent was given, histologic analysis, quantitative (q)RT-PCR, serum creatinine blood urea nitrogen testing to evaluate injury. Microarray protein–protein interaction (PPI)...
Abstract Thyroid dysgenesis (TD) accounts for 80% cases of congenital hypothyroidism, which is the most common neonatal disorder. Until now, gene mutations have been reported associated with TD can only account 5% cases, suggesting genetic heterogeneity pathology. Nicotinamide nucleotide transhydrogenase ( NNT ) plays a crucial role in regulating redox homeostasis, patients carrying described clinical phenotype hypothyroidism. As risk increased context several syndromes and homeostasis vital...
To explore the protective effect and mechanism of scutellarin (Scu) on sepsis associated-acute kidney injury (SA-AKI).(1) In vivo experiment: 36 male C57BL/6 mice were divided into normal saline (NS) control group, lipopolysaccharide (LPS) induced SA-AKI model group (LPS group), 20 mg/kg Scu (Scu 5, 10, pretreatment groups by random number table with 6 in each group. The was reproduced intraperitoneal injection 10 LPS. NS injected intraperitoneally. intraperitoneally different doses every...
Background Acute kidney injury (AKI) is a common adverse outcome following nephrectomy. The progression from AKI to acute disease (AKD) and subsequently chronic (CKD) remains concern; yet, the predictive mechanisms for these transitions are not fully understood. Interpretable machine learning (ML) models offer insights into how clinical features influence long-term renal function outcomes after nephrectomy, providing more precise framework identifying patients at risk supporting improved...
Approximately 16 million Americans suffer from rosacea according to the National Rosacea Society. To increase awareness, automatic detection methods using deep learning and explainable statistical approaches are presented in this paper. The method applies ResNet-18 for detection, utilize means of two classes, namely, class vs. normal class, principal component analysis extract features facial images detection. contributions proposed three-fold. First, able automatically distinguish patients...
This study investigates the impact of Emeishan Large Igneous Province (ELIP) on hydrocarbon formation within Anyue gas field in Sichuan Basin. As a major Middle to Late Permian large igneous province, ELIP hosted intense mantle plume activity that reshaped regional tectonics and thermal structures, indirectly influencing accumulation. paper examines three primary factors evolution linked ELIP: its influence, induced fluid activity, role cracking. Data reveal effects extend central Basin,...
Abstract Background Clinically, IgA nephropathy (IgAN) has a variety of symptoms including paroxysmal gross hematuria, nephritic syndrome and nephrotic syndrome. However, the currently research IgAN is not thoroughly enough. This study was aimed at investigating hub genes modulars related to clinical characteristics. Results We collected microarray data from 66 human samples construct gene co-expression network by weighted analysis identify associated with The GO-enriched analysis, pathway...