A5028992919- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Medicinal plant effects and applications
- Tryptophan and brain disorders
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Sex work and related issues
- Prenatal Substance Exposure Effects
- Nicotinic Acetylcholine Receptors Study
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- RNA modifications and cancer
- RNA Research and Splicing
- Lung Cancer Research Studies
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Toxin Mechanisms and Immunotoxins
- Cancer, Hypoxia, and Metabolism
- Calcium signaling and nucleotide metabolism
Lanzhou University
2011-2022
Sichuan University
2012-2018
State Key Laboratory of Biotherapy
2012-2018
Protein arginine methyltransferases (PRMTs) plays critical roles in cancer. PRMT5 has been implicated several types of tumors. However, the role cancer development remains to be fully elucidated. Here, we provide evidence that is overexpressed colorectal (CRC) cells and patient-derived primary tumors, correlated with increased cell growth decreased overall patient survival. Arginine methyltransferase inhibitor 1 (AMI-1)strongly inhibited tumor growth, ratio Bax/Bcl-2, induced apoptosis mouse...
Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly expressed in some tumors, but its role hepatocellular carcinoma (HCC) still unknown. PRMT5 level HCC specimens was determined by immunohistochemical staining and the association with clinicopathologic features evaluated. inhibited AMI-1 (a small molecule inhibitor of PRMTs) or interference RNA (siRNA). The proliferation cells tested Cell Counting Kit-8, cell migration evaluated Transwell assay cycle apoptosis were...
Abstract Cocaine dependence involves in the brain's reward circuit as well nucleus accumbens (NAc), a key region of mesolimbic dopamine pathway. Many studies have documented altered expression genes and identified transcription factor networks epigenetic processes that are fundamental to cocaine addiction. However, all these investigations focused on mRNA encoding genes, which may not always reflect involvement long non‐coding RNAs (lncRNAs), has been implied broad range biological complex...
Ginsenoside Rd (GS-Rd), isolated from the Chinese traditional herbal medicine Panax ginseng, is used for treatment of cardiovascular diseases, inflammation, different body pains, and trauma. Caspase-3 Caspase-9 belong to cysteine aspartic acid specific protease (Caspase) family that plays an important role in apoptosis progression cancers. In present study, we investigated anti-tumor effect GS-Rd by MTT assay, colony formation assessment, flow cytometry, Western blotting. Our results...
Recent evidence suggests that histone modifications play a role in the behavioral effects of cocaine rodent models. Histone arginine is known to be methylated by protein N -methyltransferases (PRMTs). Evidence shows PRMT1 contributes >90% cellular PRMT activity, which regulates H4 3 asymmetric dimethylation (H4R3me2a). Though methylation represents chemical modification relatively stable compared with other alterations, it less well studied setting addiction. Here, we demonstrate repeated...
Nicotine, one of the most commonly used drugs, has become a major concern because tobacco serves as gateway drug and is linked to illicit abuse, such cocaine marijuana. However, previous studies mainly focused on certain genes or neurotransmitters which have already been known participate in addiction, lacking endogenous metabolic profiling global view. To further explore mechanism by nicotine modifies response cocaine, we developed two conditioned place preference (CPP) models mice. In...
The aim of this study was to establish xenograft models tumor in mice bladder and evaluate the antitumor efficacy ampelopsin sodium (Amp-Na). A total 2×106 human carcinoma EJ cells murine sarcoma 180 were instilled into BALB/c nu/nu Swiss after preconditioning model. Mice bearing orthotopic tumors treated with Amp-Na by intravenous, intraperitoneal, or intravesical instillation. In addition, pharmacokinetics property investigated normal mice. Our results showed that excreted mainly through...
Nicotine is rapidly absorbed from cigarette smoke and therefore induces a number of chronic illnesses with the widespread use tobacco products. Studies have shown few cerebral metabolites modified by nicotine; however, endogenous metabolic profiling in brain has not been well explored. H NMR-based on metabonomics was applied to investigate hippocampus, nucleus acumens (NAc), prefrontal cortex (PFC) striatum. We found that nicotine significantly increased CPP mice, some specific...
Protein arginine methyltransferases (PRMTs) are a class of epigenetic modified enzymes that overexpressed in various types cancer and serve pivotal functions malignant transformation. Arginine methyltransferase inhibitor-1 (AMI-1) is symmetrical sulfonated urea inhibits the activity type I PRMT vitro. However, previous studies demonstrated AMI-1 may also inhibit II PRMT5 To best our knowledge, present study provides first evidence significantly viability mouse sarcoma 180 (S180) human...
Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly expressed in several types of tumors including cervical cancer. Arginine inhibitor 1 (AMI-1) inhibits solid by targeting PRMT5. However, the effect AMI-1 on cancer still unknown. In this study, we provided first evidence that reduced cell proliferation, colony formation and promoted apoptosis vitro. Suppression tumorigenicity was also confirmed vivo. Mechanistic studies revealed significantly PRMT5 level cells mice...
Protein arginine methyltransferases 1 and 5 (PRMT1 PRMT5) are frequently overexpressed in diverse types of cancers correlate with poor prognosis, thus making these enzymes potential therapeutic targets. The aim this study was to assess elucidate the anti-tumour effect epigenetic regulatory mechanism ribavirin soft tissue sarcomas (STS). We showed that inhibited growth metastasis prolonged survival animals bearing STS cells by downregulating mRNA protein levels PRMT1/PRMT5 attenuating...
Previous studies have demonstrated that ampelopsin (AMP), a type of flavonoid isolated from the stems and leaves Ampelopsis grossedentata, exhibits anti-cancer activity in various types cancer. Conversion AMP into its sodium salt (AMP-Na) conferred enhanced solubility stability to it. The present study aimed evaluate AMP-Na human lung adenocarcinoma cell lines investigate mechanisms action. Cell proliferation viability were assessed by MTT colony formation assays, migration was determined...