A5101945827- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Sex work and related issues
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Intracerebral and Subarachnoid Hemorrhage Research
- IL-33, ST2, and ILC Pathways
Xinjiang Medical University
2022
Xinjiang Uygur Autonomous Region Uygur Medicine Hospital
2020
State Key Laboratory of Biotherapy
2015
Sichuan University
2015
Protein arginine methyltransferases (PRMTs) plays critical roles in cancer. PRMT5 has been implicated several types of tumors. However, the role cancer development remains to be fully elucidated. Here, we provide evidence that is overexpressed colorectal (CRC) cells and patient-derived primary tumors, correlated with increased cell growth decreased overall patient survival. Arginine methyltransferase inhibitor 1 (AMI-1)strongly inhibited tumor growth, ratio Bax/Bcl-2, induced apoptosis mouse...
Recent evidence suggests that histone modifications play a role in the behavioral effects of cocaine rodent models. Histone arginine is known to be methylated by protein N -methyltransferases (PRMTs). Evidence shows PRMT1 contributes >90% cellular PRMT activity, which regulates H4 3 asymmetric dimethylation (H4R3me2a). Though methylation represents chemical modification relatively stable compared with other alterations, it less well studied setting addiction. Here, we demonstrate repeated...
Diabetic retinopathy (DR), as the most frequent microvascular complication of diabetes mellitus (DM), causes vision loss and blindness in adults worldwide with increasing incidence. MicroRNAs (miRNAs) are involved regulation DR. However, role miR-542-5p is still unknown. Here, we demonstrate that down-regulated patients DR high-glucose (HG)-treated retinal pigment epithelial cells. Moreover, overexpression inhibits apoptosis cells exposed to HG. The interaction between...