A5100738370- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Heavy Metal Exposure and Toxicity
- Adenosine and Purinergic Signaling
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Mechanisms and Therapy
Guangxi University
2023
Guangxi University of Chinese Medicine
2023
Xinjiang Uygur Autonomous Region Uygur Medicine Hospital
2020
Shantou University
2018
Shantou University Medical College
2018
First Hospital of Lanzhou University
2017
Lanzhou University
2017
MicroRNAs (miRNAs) are a group of non-protein-coding, highly conserved single-stranded RNA molecules. The abnormal expression miRNAs has been demonstrated to have an important function in the carcinogenesis and progression gastric cancer. microRNA-154 (miR-154) reported be downregulated non-small cell lung, colorectal prostate However, roles miR-154 cancer remain established. present study measured levels tissues lines. was found significantly In addition, functional studies indicated that...
Cadmium (Cd), a carcinogenic toxic metal, is pervasively distributed in the soil, water and air. Chronic exposure to Cd has been correlated lung disease development including cancers. Although many studies have conducted investigate proteome response of cells challenged with Cd, epiproteomic responses (i.e., global histone post-translational modifications [PTMs]), particularly human cells, are largely unexplored. Here, we provide an epiproteome profiling bronchial epithelial (BEAS-2B)...
Triple-negative breast cancer (TNBC) is an aggressive subtype of BC characterized by extensive intratumoral heterogeneity. Compared with other types BC, TNBC more prone to invasion and metastasis. The aim the present study was determine whether adenovirus-mediated clustered regulatory interspaced short palindromic repeats (CRISPR)/Cas9 system capable effectively targeting enhancer zeste homolog 2 (EZH2) in cells lay experimental basis for investigation CRISPR/Cas9 as a gene therapy BC. In...
Diabetic retinopathy (DR), as the most frequent microvascular complication of diabetes mellitus (DM), causes vision loss and blindness in adults worldwide with increasing incidence. MicroRNAs (miRNAs) are involved regulation DR. However, role miR-542-5p is still unknown. Here, we demonstrate that down-regulated patients DR high-glucose (HG)-treated retinal pigment epithelial cells. Moreover, overexpression inhibits apoptosis cells exposed to HG. The interaction between...