A5059795817- Cyclopropane Reaction Mechanisms
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Supramolecular Self-Assembly in Materials
- Catalytic C–H Functionalization Methods
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Wind and Air Flow Studies
- Polymer Surface Interaction Studies
- Topology Optimization in Engineering
- Gold and Silver Nanoparticles Synthesis and Applications
- Urban Heat Island Mitigation
- Sulfur-Based Synthesis Techniques
- Building Energy and Comfort Optimization
- Photonic Crystals and Applications
- Mineral Processing and Grinding
- Advanced Nanomaterials in Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Advanced Numerical Analysis Techniques
- Pickering emulsions and particle stabilization
- Nanomaterials for catalytic reactions
- DNA and Nucleic Acid Chemistry
- Photoacoustic and Ultrasonic Imaging
Southeast University
2020-2024
Nankai University
2008-2024
State Key Laboratory of Medicinal Chemical Biology
2017-2024
University College London
2024
University of South China
2016-2024
Jiangxi Normal University
2022
Kunming Institute of Botany
2022
Chinese Academy of Sciences
2022
Shenzhen University Health Science Center
2021
Shenzhen Second People's Hospital
2021
The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, TiO2 supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO2 SAN) designed to serve as highly efficient antiviral nanomaterial. Compared with traditional nano-TiO2 and Ag, Ag-TiO2 SAN exhibits higher adsorption (99.65%) SARS-CoV2 pseudovirus. This ability due interaction...
Special delivery: A supramolecular nanoparticle provides a facile and modular protein delivery system (see picture, TAT enables cell membrane penetration, RGD targeting, PEG passivation) for highly efficient transduction of intact (unmodified) transcription factors (TF). Such TF approach powerful method manipulating cellular behavior. Detailed facts importance to specialist readers are published as "Supporting Information". documents peer-reviewed, but not copy-edited or typeset. They made...
A copper-mediated, three-component reaction between two different N-Ts hydrazones and elemental sulfur was developed, leading to a series of unsymmetric 2,5-disubstituted 1,3,4-thiadiazoles in moderate yields with good functional group compatibility. This procedure features the employment selective denitrogenation aryl alkyl aldehyde N-tosyl hydrazones, allowing rapid access frameworks chemical diversity complexity.
We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal–oxide–semiconductor active pixel sensor imaging and see-through display technologies. The is compact wearable intraoperative that can guide surgery in real time. capable of detecting indocyanine green solution picomolar range. Aided by NIR quantum dots, we successfully used to sentinel lymph node mapping rat model. further demonstrated feasibility using guiding surgical resection breast cancer...
Nanovaccines have shown the promising potential in controlling and eradicating threat of infectious diseases worldwide. There has been a great need developing versatile strategy to conveniently construct diverse types nanovaccines induce potent immune responses. To that end, it is critical for obtaining self-adjuvant platform assemble with different antigens into nanovaccines.
An efficient amination reaction of 3-substituted benzofuran-2(3H)-ones promoted by cesium carbonate was developed. A putative mechanism involving a single-electron-transfer event proposed, which represents new reactivity for benzofuran-2(3H)-ones.
It still remains a big challenge to fabricate binary colloidal crystals (binary CCs) from hard spheres, although lot of efforts have been made. Here, for the first time, CCs are assembled soft hydrogel PNIPAM microgels, instead spheres. Different microgel can be facilely fabricated by simply heating dispersions 37 °C and then allowing them cool back room temperature. The formation highly ordered structure is indicated appearance an iridescent color sharp Bragg diffraction peak. Compared with...
A nickel-catalyzed coupling of N-sulfonyl-1,2,3-triazole with various H-phosphine oxides for the construction C(sp2)-P bonds is established. This unexpected reaction proceeds through a formal nickel-bound ketenimine pathway, representing previously unknown 1,2-reactivity type an azavinyl carbene. The method provides efficient approach to stereoselective and site-selective synthesis α-aminovinylphosphoryl derivatives moderate good yield. plausible mechanism proposed based on experimental...
Annulative η 3 ‐allylpalladium chemistry has been a longstanding trending research topic since the 80's. Nowadays, this area is still providing challenges to catalysis community leading development original and brand‐new transformations. Several reaction partners have used as precursors for species, namely allyl diacetates, monoacetates, 3‐acetoxy‐2‐trimethylsilylmethyl‐1‐propene (ASMP), alkylidene cyclopropanes (ACPs), vinyl (VCPs), aziridines, epoxides. This minireview intended show recent...
Real-time tracking of drug release from nanomedicine in vivo is crucial for optimizing its therapeutic efficacy clinical settings, particularly dosage control and determining the optimal window. However, most current real-time systems require a tedious synthesis purification process. Herein, supramolecular nano-tracker (SNT) capable based on non-covalent host-guest interactions presented. By integrating multiple cavities into single nanoparticle, SNT achieves co-loading drugs probes while...
The blood-spinal cord barrier (BSCB) prevents many macromolecular agents from passing through to reach sites of injury in the spinal cord. This study evaluated ability a novel multifunctional liposome modified with polyethylene glycol (PEG) and transactivating-transduction protein (TAT) containing an iron core cross BSCB using rat model injury. Rats were examined daily for period three days after injection either or control formulations 3.0 T magnetic resonance imaging spectrometer. A low...