A5072739072- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Ophthalmology and Eye Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Vestibular and auditory disorders
- Neuropeptides and Animal Physiology
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Neurology and Historical Studies
- Psychosomatic Disorders and Their Treatments
- Cerebral Venous Sinus Thrombosis
- Nitric Oxide and Endothelin Effects
- Botulinum Toxin and Related Neurological Disorders
- Spine and Intervertebral Disc Pathology
- Neurological Complications and Syndromes
- Pain Mechanisms and Treatments
- Oropharyngeal Anatomy and Pathologies
- Meningioma and schwannoma management
- Facial Nerve Paralysis Treatment and Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Syncope and Autonomic Disorders
- History of Medicine Studies
- Neurosurgical Procedures and Complications
- Biochemical effects in animals
Eli Lilly (United States)
2017-2025
Universidade Federal do Rio de Janeiro
2009-2024
Queen Elizabeth Hospital
2020
Hospital Universitário Clementino Fraga Filho
2002-2016
Universidade do Estado do Rio de Janeiro
2015
National Council for Scientific and Technological Development
2014
Albert Einstein College of Medicine
2014
Universidade Federal dos Vales do Jequitinhonha e Mucuri
2014
Howard Hughes Medical Institute
2010
National Institutes of Health
2010
Migraine has been traditionally considered a nonprogressive, paroxysmal disorder with no brain abnormalities between attacks. We used diffusion tensor imaging to examine interictal properties of the brains migraineurs aura, without aura and matched healthy controls. Areas lower fractional anisotropy were present in along thalamocortical tract. In addition, had ventral trigeminothalamic tract, ventrolateral periaqueductal grey matter. Our results indicate presence permanent changes...
Migraine affects the cortical physiology and may induce dysfunction both ictally interictally. Although visual symptoms predominate during aura, other contiguous areas related to less impressive are also impaired in migraine. Answers from 72.2% migraine with aura 48.6% of without patients on human faces objects recognition, colour perception, proper names recalling memory general showed dysfunctions suggestive prosopagnosia, dyschromatopsia, ideational apraxia, alien hand syndrome, name...
Chronic pain disorders are presumed to induce changes in brain grey and white matters. Few studies have focused CNS alterations trigeminal neuralgia (TN). The aim of this study was explore matter microstructure TN subjects using diffusion tensor images (DTI) with tract-based spatial statistics (TBSS); cortical thickness surface based morphometry. Twenty-four patients classical (37-67 y-o) 24 healthy controls, matched for age sex, were included the study. Comparing no diffusivity...
Background: Although neuroimaging techniques have provided insights into the function of brain regions involved in Trigeminal Neuropathic Pain (TNP) humans, there is little understanding molecular mechanisms affected during course this disorder. Understanding these processes crucial to determine systems development and persistence TNP. Findings: In study, we examined regional μ-opioid receptor (μOR) availability vivo (non-displaceable binding potential BP ND ) TNP patients with positron...
Background Migraine, particularly chronic migraine (CM), is underdiagnosed and undertreated worldwide. Our objective was to develop validate a self-administered tool (ID-CM) identify CM. Methods ID-CM developed in four stages. (1) Expert clinicians suggested candidate items from existing instruments experience (Delphi Panel method). (2) Candidate were reviewed by people with CM during cognitive debriefing interviews. (3) Items administered Web panel of severe headache assess psychometric...
Since visual aura is usually described as expanding zigzag lines, neurones involved with the perception of line orientation may initiate this phenomenon. A incongruent stimulation protocol was developed to obtain functional magnetic resonance images (fMRI) interictally in 5 female migraine patients typical fortification spectra and normal matched controls. Activation cortex present contralateral side 4 patients, notably extrastriate cortex. In controls activation observed medial anterior...
The clinical manifestations of supraorbital neuralgia are apparently only incompletely known. lack awareness this head pain may possibly be due to its rarity and problems with making the diagnosis. In present work, long‐term result minor, decompressive surgery nerve in five patients is reported. immediate improvement was good and, after a mean observation time more than 6 years, an 50% 100% observed (mean, circa 85%). two longest postoperative time, approximately 8 has not recurred. severe,...
Cervicogenic headache (CEH) is a neck-generated syndrome. Attacks may be similar to migraine (M) or tension-type (TTH). In order test the accuracy of IHS diagnostic criteria for M and episodic TTH CEH Sjaastad et al., 33 CEH, 65 M, 29 were evaluated according criteria, patients tested criteria. Only 30% met 3% TTH, 66% neither nor TTH. The mean number met, sex, age, age onset also analysed, results indicate an inequality among these three types. most important differentiating aspects site...
OBJECTIVE: To test the ability of a 5HT2a/c (trazodone) antagonist, to improve depression and motor function in Parkinson' disease (PD). METHOD: Twenty PD patients with without were randomly assigned receive trazodone (group 1) or not 2). They evaluated through UPDRS Hamilton Depression Rating Scale (HAM-D). RESULTS: For mean score group 2 was 33.1 ± 19.7 37.1 18.0 at end. 1, corresponding scores 31.4 11.3 25.9 13.7. The variations Mann-Whitney 0.734 initial moment 0.208 final moment....
Proposals for the diagnostic criteria hemicrania continua (HC) and also nosological status of HC are set forth. The clinical constellation symptoms signs making up consists of: unilaterality without side shift; absolute indomethacin effect; long-lasting repetitive attacks varying duration, eventually with a chronic pattern, pain being mild to severe. For typical picture HC, including positive 'indotest', we propose term vera. More or less analogous, but 'indotest-negative' pictures have...
Chronic migraine is a condition with significant prevalence all around the world and high socioeconomic impact, its handling has been challenging neurologists. Developments for understanding mechanisms associated conditions, as well that of new therapies, have quick important, fact which motivated Latin American Brazilian Headache Societies to prepare present consensus. The treatment chronic should always be preceded by careful diagnosis review; detection possible worsening factors...
In this article, a group of experts in headache management the Brazilian Headache Society developed through consensus strategic measurements to treat migraine attack both child and adult. Particular emphasis was laid on treatment women, including at pregnancy, lactation perimenstrual period.
Perimenstrual migraine attacks in women with menstrual is difficult to treat. This post-hoc analysis evaluated the efficacy of lasmiditan, a high affinity and selective 5-HT1F receptor agonist, for perimenstrual attacks.Patients from two randomized, double-blind, placebo-controlled clinical trials (MONONOFU CENTURION) were instructed treat an attack single dose study medication within four hours pain onset. After dosing, proportion patients who achieved freedom migraine-related head pain,...